ERBB3 polyclonal antibody
- Known as:
- ERBB3 pab (anti-)
- Catalog number:
- PAB9951
- Product Quantity:
- 50 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- ERBB3 polyclonal antibody
Related genes to: ERBB3 polyclonal antibody
- Gene:
- ERBB3 NIH gene
- Name:
- erb-b2 receptor tyrosine kinase 3
- Previous symbol:
- LCCS2
- Synonyms:
- HER3
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-15
- Date modifiied:
- 2019-04-23
Related products to: ERBB3 polyclonal antibody
Related articles to: ERBB3 polyclonal antibody
- Endometrial cancer is a common gynecological malignancy, and elucidating its molecular basis may provide new clues for targeted intervention. This study investigated the role of ERBB3 in endometrial cancer cells and explored whether Ras-ERK/MAPK signaling is involved in ERBB3-mediated regulation. - Source: PubMed
Publication date: 2026/05/28
Liu YuanlinLi HuLi XiaofengLi MingyuanLi Yiran - Thymic epithelial tumors (TETs), which include thymomas and thymic carcinomas (TCs), are the most common neoplasms of the anterior mediastinum. To develop more effective therapeutics, it is necessary to better understand their molecular characteristics. - Source: PubMed
Publication date: 2026/06/08
Kim ChulAdeyelu TolulopeManiar RohanFarrell AlexZaemes JacobSolzak JeffreyHancock BradleyElliott AndrewMicaily IdaNagasaka MisakoNieva JorgeBorghaei HosseinHalmos BalazsMa Patrick CRadovich MilanBadve Sunil SLoehrer Patrick J - The EGF receptor tyrosine kinase binds seven different agonist ligands. EGF stimulates proliferation of MCF-7 cells while EPG and EPR, stimulate differentiation. This distinction is thought to be due to the phenomenon of ligand bias in which two agonists bind to the same receptor but generate different responses. These reported differences among EGFR ligands led us to examine their effects plus those of NRG-2ß, an ErbB3-ErbB4 ligand, on metabolism in MCF-7 cells and MDA-MB-468 cells. We followed the flux of carbons from either [1,2-C]-glucose or [U-C]-glutamine through the early pathways of intermediary metabolism. EGF stimulated flux through glycolysis, the pentose phosphate pathway (PPP) and the TCA cycle in both lines. However, MCF-7 cells channeled ribose from the PPP into nucleotide biosynthesis whereas MDA-MB-468 cells recycled the riboses through the non-oxidative pathway of the PPP back into glycolysis. In MDA-MB-468 cells, all EGF receptor ligands induced a similar level of metabolic flux while NRG-2ß was inactive. By contrast, in MCF-7 cells, NRG-2ß, BTC, EPR, and EPG were significantly more effective at stimulating metabolic flux than the other EGF receptor ligands. Thus, bias was apparent in MCF-7 cells but not in MD-MB-468 cells. As the two lines express different complements of ErbB family receptors, we speculate that the differences in response are the result of different ligands preferentially inducing specific homodimer or heterodimer pairings. Our findings highlight the need to consider the possibility of system bias in cells when interpreting data related to ligand bias. - Source: PubMed
Publication date: 2026/06/04
Macdonald-Obermann JenniferCho KevinPatti Gary JPike Linda J - The study investigated the interaction between estrogen deprivation and periodontitis, systemically, in the bone marrow, and locally in periodontal tissues using a mouse model. - Source: PubMed
Publication date: 2026/05/19
Yakar NilHasturk HaticeRivas Carla AlvarezZimmerman PhraoGuney ZelihaYilmaz Birtan TolgaUzun YasinTrackman PhilipKantarci Alpdogan - - Source: PubMed
Publication date: 2026/05/19
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