Dab1 polyclonal antibody
- Known as:
- Dab1 pab (anti-)
- Catalog number:
- PAB9857
- Product Quantity:
- 50 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- Dab1 polyclonal antibody
Related genes to: Dab1 polyclonal antibody
- Gene:
- DAB1 NIH gene
- Name:
- DAB adaptor protein 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p32.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-12
- Date modifiied:
- 2019-01-31
Related products to: Dab1 polyclonal antibody
Related articles to: Dab1 polyclonal antibody
- Neural circuit assembly requires precise coordinated interactions between developing neurons and the vasculature; yet, the instructive signals provided by endothelial cells remain largely unknown. Here, we find a vascular-to-neural signaling axis that orchestrates postnatal cerebellar development. Endothelial-specific deletion of the adapter protein Dab1 (Dab1) in mice disrupts vascular patterning and uncouples the growth of major cerebellar neuronal populations. We show that endothelial Dab1 in the cerebellum drives secretion of the morphogen Wnt5a, which acts through Frizzled-2 to restrain granule-cell progenitor proliferation and promotes Purkinje cell dendritic maturation. Endothelial Wnt5a deletion phenocopies Dab1 defects, whereas exogenous Wnt5a restores normal progenitor dynamics in Dab1 cerebellar slices, demonstrating pathway sufficiency. Functionally, loss of this vascular signal impairs Purkinje cell firing, diminishes parallel-fiber input, reduces synapse formation from both parallel and climbing fibers, and disrupts long-term plasticity. These findings indicate a key instructive role for blood vessels in shaping cerebellar architecture and establishing functional circuit connectivity. - Source: PubMed
Publication date: 2026/07/25
Parrilla MartaHülse RobertJin JingD'Errico AnnaRedondo-Nectalí JimenaSrivastava SwatiStuth FrederikeAlivodej NensiLlaó-Cid CecíliaAburto María RSegarra MartaAcker-Palmer Amparo - Cerebral angiogenesis is essential for brain development and the maintenance of homeostasis. The secreted glycoprotein Reelin has been implicated in this process; however, the underlying mechanisms, particularly its functional relationship with the axon guidance molecule Netrin-4, remain incompletely understood. In this study, we used Reln mouse models and bEnd.3 brain microvascular endothelial cells. Experimental approaches included western blotting, immunofluorescence, quantitative PCR (qPCR), in vitro tube formation assays, chromatin immunoprecipitation (ChIP), and dual-luciferase reporter assays. Functional validation was performed by intracerebroventricular injection of recombinant Reelin protein, the mTOR inhibitor rapamycin, and recombinant Netrin-4. Compared with wild-type mice, Reln mice exhibited significantly reduced Netrin-4 expression and markedly impaired angiogenic capacity. These defects were rescued by exogenous Reelin through the Dab1/mTOR/HIF-1α pathway. Direct supplementation with Netrin-4 similarly restored angiogenesis. In vitro experiments confirmed the conservation of this pathway, and ChIP analysis together with luciferase reporter assays demonstrated direct binding of HIF-1α to the Netrin-4 promoter. In summary, this study identifies the Reelin-Dab1-mTOR-HIF-1α-Netrin-4 axis as a signaling pathway that is associated with cerebral angiogenesis during development. - Source: PubMed
Publication date: 2026/06/26
Feng ZhaoweiPan MeihuaLiu HuiLiu MeitingYang JiahuiWang Chun-YuYao RuiqinLiu HaiyanFu Yanyan - Epilepsy is a complex neurological disorder significantly influenced by genetic factors. Observational studies can identify associations, but cannot establish causality. Mendelian randomization (MR) offers a robust tool for identifying etiology. Therefore, using multi-omics, we explored genetically proxied associations among cerebrospinal fluid metabolites, neuroimaging phenotypes, and epilepsy to prioritize candidate genes and potential therapeutic targets. - Source: PubMed
Publication date: 2026/06/26
Sun HuaiyuLi XueweiZhao WeixuanMeng HongmeiZhang Wuqiong - Selection to increase the frequency of useful mutations has left marks on animal genomes, genetic diversity, and population structure within populations. The study and investigation of these genomic regions can lead to the identification of genes related to economic traits or competence and adaptability. This study aimed to recognize genetic diversity, population structure, and selection signatures in Iranian (IB) and Afghan (AB) Baluchi sheep populations. In this study, 86 Iranian Baluchi and 15 Afghan Baluchi sheep were genotyped using Illumine Ovine SNP50K Beadchip arrays. Note that the sample size imbalance (IB n = 86 vs. AB n = 15) may reduce statistical power and potentially bias population structure and selection scan results. Additionally, use of the Ovine 50K array may introduce ascertainment bias; analyses were based on 38,193 shared SNPs, potentially missing population-specific variants. Generally, moderate genetic diversity was observed in both the Afghan Baluchi (AB) and Iranian Baluchi (IB) sheep populations, using various assessment methods. However, the IB population showed the lowest level of genetic diversity and the highest rate of linkage disequilibrium decay, despite having a better effective population size in recent generations. The ADMIXTURE analysis indicated that the optimal number of genetic clusters was K = 2, which was determined based on the lowest cross-entropy error of 0.603 observed during cross-validation. At K = 2 and NJ tree analysis, a clear genetic distinction between the AB and IB populations was evident. Additionally, the IB population demonstrated significant genetic uniformity when compared to the AB population in terms of genetic distance. Also, FST and XP-EHH were used to identify selection signatures. Some putative candidate genes for FST, including HDAC9, CSMD3, DAB1, FGF12, and PCDH9 were associated with important economic traits such as body weight, hot carcass weight, muscle weight in carcass, reproductive seasonality, and carcass fat percentage, respectively. Also, XP-EHH putative candidate genes were KCNIP4, FGF11, CNTROB, and ROBO2 in AB population, which were related to body weight, hot carcass weight, milk yield, and muscle weight in carcass. Moreover, XP-EHH putative candidate genes in IB population were GRIK3, NCOA1, and FGD3, that related to muscle weight in carcass, staple length, and milk fat percentage. Selection signals were identified using top 1% FST thresholds and XP-EHH without genome-wide multiple-testing correction; results require experimental validation. We observed very similar outcomes in terms of similar signatures related to economic traits in both FST and XP-EHH methods, indicating the robustness of analysis in this study. It can be concluded that selection has made a major distinction between Afghan and Iranian Baluchi sheep populations for reproduction, milk production, and growth traits. These could be due to the managed breeding programme in Iranian Baluchi sheep. Utilizing validated QTLs as described in this study could be applied to reveal the direction of breeding plans in livestock species. - Source: PubMed
Publication date: 2026/06/17
Taheri SadeghKarimi Mohammad OsmanSaedi NaghmehZerehdaran SaeedShariati Mohammad MahdiGholizadeh MohsenJavadmanesh Ali - The roles of Reelin and L1 cell adhesion molecule (L1CAM)-long regarded as separate regulators of neuronal migration and axon guidance-are now understood as components of a complementary signal transduction axis with significant implications for neural repair. Recent evidence has shown that Reelin activates Dab1 through the receptors ApoER2 and VLDLR, inducing Src family kinase cascades and subsequent PI3K-Akt, MAPK/ERK and cytoskeletal remodelling pathways, as well as regulating the activity of L1CAM. Particularly, Reelin seems to play a role in the neurite outgrowth promoted by L1CAM through its proteolytic cleavage, its modulation of integrin activity and the coordination of kinase binding in the axonal extension process. These meticulously synchronised processes imply that there is a common input to axonal sprouting and rearrangement of synapses as well as inflammatory regulation during the posttraumatic period of central nervous system injury. Overall, Reelin and L1CAM form a mechanistically coherent network that facilitates regeneration-related signalling, thus providing a more viable basis for new therapeutic approaches that involve the use of recombinant proteins, peptides, protease regulation or gene-directed interventions to promote neural repair. - Source: PubMed
Sahu Sudhanshu