Cacna2d2 polyclonal antibody
- Known as:
- Cacna2d2 pab (anti-)
- Catalog number:
- PAB9798
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- Cacna2d2 polyclonal antibody
Related genes to: Cacna2d2 polyclonal antibody
- Gene:
- CACNA2D2 NIH gene
- Name:
- calcium voltage-gated channel auxiliary subunit alpha2delta 2
- Previous symbol:
- -
- Synonyms:
- KIAA0558
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-11
- Date modifiied:
- 2016-10-05
Related products to: Cacna2d2 polyclonal antibody
Related articles to: Cacna2d2 polyclonal antibody
- The progression of lung adenocarcinoma (LUAD) is influenced by polyamine metabolism, which modulates antitumor immunity, although the underlying mechanisms remain unclear. The present study investigates the role of polyamine metabolism-related genes (PMRGs) in LUAD using transcriptomic data, single-cell RNA sequencing (scRNA-seq) and Mendelian randomization. Differentially expressed PMRGs were identified through differential expression analysis and weighted gene co-expression network analysis. Prognostic genes were selected via Cox regression and least absolute shrinkage and selection operator regression to construct a risk model. Immune infiltration, machine learning and scRNA-seq were employed to explore molecular mechanisms whilst reverse transcription-quantitative PCR (RT-qPCR) validated gene expression in LUAD tissues. A nomogram incorporating risk scores assisted in predicting LUAD prognosis (area under the curve >0.6). Distinct immune cell profiles, particularly involving B cells and CD4 T cells, were observed between high- and low-risk groups. Drug sensitivity analysis identified 15 drugs with differential responses. Epithelial cells emerged as a key cluster, with dynamic changes in calcium voltage-gated channel auxiliary subunit α2δ2 (CACNA2D2) expression during pseudotime. RT-qPCR confirmed the downregulation of prognostic genes in LUAD. A polyamine metabolism-related prognostic signature (CACNA2D2, adenoreceptor β-1, immunoglobulin superfamily member 10 and carbonic anhydrase 4) associated with the tumor microenvironment was established, offering potential for enhanced prognosis prediction in LUAD. - Source: PubMed
Publication date: 2026/05/21
Yang HuaZhang LemengChen JianhuaZhang Junjie - Tooth agenesis (TA) is a common developmental anomaly of the dentition with marked phenotypic and genetic heterogeneity, yet data from Middle Eastern families are limited. The aims of this study were twofold: first, to describe the clinical features and inheritance patterns of familial TA in Lebanese kindreds and to investigate rare segregating exonic variants that may contribute to these phenotypes; and second, to provide a clinic‑based estimate of TA prevalence and patterns in the same population context. - Source: PubMed
Publication date: 2026/05/06
Nabbout FideleEl Hajj JoelleBadran BassamGhassibe Michella - The poor prognosis of lung adenocarcinoma (LUAD) remains unimproved. This study aimed to identify lymph node metastasis (LNM)-related and cellular immunity-related prognostic genes in LUAD and propose novel strategies to improve its prognosis. LUAD-related datasets were obtained from public databases. Prognostic genes and a prognostic model were obtained through various bioinformatics analyzes, and the immunotherapy response in risk groups was assessed. Subsequently, the expression levels of prognostic genes and the intercellular communication relationships were explored at the single-cell level. Moreover, malignant cells were identified, and their differentiation mechanisms were explored via inferCNV analysis. Additionally, FURIN was silenced and overexpressed to investigate its effects on the invasion, metastasis, and lymphangiogenesis of LUAD cells in vitro. RGS20, KYNU, RAET1E, FGF12, GJB2, CACNA2D2, FURIN, and GDF10 were identified as prognostic genes with LNM. In 4 datasets, LUAD patients with the high LNM and immune cell-related risk scores exhibited higher mortality rates compared to those in the low-risk group. Furthermore, individuals in the low-risk group demonstrated a greater propensity to derive advantages from immunotherapeutic interventions. Epithelial cells were identified as key cells, with CACNA2D2 being significantly up-regulated during their late-stage differentiation. Basal cells, the malignant subset within epithelial cells, showed elevated FURIN expression in the pre-differentiation phase, which declined in the middle and late phases. Functionally, FURIN was found to enhance the migratory and proliferative capacities of LUAD cells. Moreover, we demonstrated that FURIN accelerated lymphatic metastasis and lymphangiogenesis in vitro. In this paper, we identified LUAD prognostic genes with LNM and immune cell signatures, emphasized treating LUAD patients according to LNM- and immune cell-related risk scores, and provided novel ideas on how to improve poor prognosis and develop targeted therapy for LUAD. - Source: PubMed
Lin ChuanChen XuanSun YongTang XiaomeiJiang Yi - Epilepsy is a chronic neurological disorder characterized by recurrent seizures, with variants in ion channel genes such as SCN1A, SCN1B, and CACNA2D2 implicated in neuronal excitability. This research aims to explore genetic polymorphisms in the SCN1A, SCN1B, and CACNA2D2 genes among Turkish epilepsy patients and assess their impact on responsiveness to anti-seizure medications (ASMs). - Source: PubMed
Publication date: 2026/04/10
Todurga-Seven Zeynep GizemPekkoc-Uyanik Kubra CigdemAgay Erhan Rasit - Cerebellar disease in ruminants is often virus-induced and non-genetic, but there are also rare inherited forms of cerebellar hypoplasia and cerebellar abiotrophy (CA). So far, no causal variant has been reported for these conditions in cattle. Two inbred Angus calves suspected of having cerebellar disease were reported in Scotland. The aims of this study were to characterize the clinicopathological phenotype of Angus calves affected by a cerebellar disease, to identify a causal variant assuming autosomal monogenic recessive inheritance and to evaluate its prevalence in Angus populations. Clinicopathological investigations were performed, including the exclusion of prevalent teratogenic viruses as well as a multiple-case whole-genome sequencing (WGS) approach. The two affected Angus calves showed congenital intention tremor and brain examination detected cerebellar abiotrophy. Genetic analysis identified a private homozygous missense variant in the bovine CACNA2D2 gene (XP_024839037.1:p.(Cys395Arg)), which is linked to neurological disorders in other species, including a form of cerebellar atrophy in humans. This variant was classified as pathogenic and shown to be absent in sequence data from over 5000 other cattle with available WGS data as well as in a cohort of 16 purebred Angus cattle from Switzerland. The variant is proposed to cause a rare form of CA in Angus and therefore should be monitored in the Angus global population, as previous similar cases were reported elsewhere. For the first time, we characterized a genetic form of cerebellar disease in cattle, providing the first large animal model for a condition related to the CACNA2D2 gene. - Source: PubMed
Jacinto JoanaChianini FrancescaMoore JoGeraghty TimothyHäfliger Irene MSeefried Franz RJones AlwynCarty HelenLetko AnnaDrögemüller Cord