Cacna2d2 polyclonal antibody
- Known as:
- Cacna2d2 pab (anti-)
- Catalog number:
- PAB9798
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- Cacna2d2 polyclonal antibody
Related genes to: Cacna2d2 polyclonal antibody
- Gene:
- CACNA2D2 NIH gene
- Name:
- calcium voltage-gated channel auxiliary subunit alpha2delta 2
- Previous symbol:
- -
- Synonyms:
- KIAA0558
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-11
- Date modifiied:
- 2016-10-05
Related products to: Cacna2d2 polyclonal antibody
Related articles to: Cacna2d2 polyclonal antibody
- Psychiatric and cardiovascular diseases (CVDs) are frequently comorbid and are interconnected through the brain-heart axis. However, the underlying shared genetic etiology remains unknown in East Asians. To address this critical gap, we conducted a genome-wide pairwise trait pleiotropy study by leveraging genome-wide association studies of three major psychiatric disorders (schizophrenia [SCZ], bipolar disorder [BIP], major depressive disorder [MDD]) and ten cardiovascular traits (including eight CVDs) in East Asians. We identified genetic overlaps across seven disease pairs, such as SCZ with coronary artery disease. Through this pairwise approach, six of a total of 18 pleiotropic loci demonstrated tissue-specific expression in brain and cardiovascular systems. In the cross-ancestry replication, nine of the pleiotropic loci were validated. Among the novel pleiotropic genes, TPCN1, CACNA2D2, CACNA1D, and ATP2B1 are involved in voltage-dependent calcium channel activity, regulation of calcium influx, enriched in calcium-related pathway. We validated association with calcium signal pathway in an independent cohort. Calcium pathway-specific polygenic risk score for SCZ was associated with prolonged corrected QT (QTc) interval, which remained robust among individuals free from QTc-affecting drugs. Given that calcium-channel blockers are commonly prescribed for heart and blood vessel conditions, we performed drug target analysis by integrating gene expression profiles from the brain and cardiovascular tissues. Our findings implicated that calcium-channel blockers and peripheral vasodilators elevated SCZ risk, diuretics reduced the risks of SCZ, BIP, and MDD. Our study reveals extensive shared genetic architectures underlying psychiatric and CVDs, which warrant prudence in the use of calcium channel blockers among patients with concurrent psychiatric and CVDs. - Source: PubMed
Publication date: 2026/07/11
Zhu YunqingZhao GuoruiZhang YuyananLu ZheKang ZheweiFeng XiaoyangLiao YundanSun JunyuanYuan RuiYang YangGuo JingLiu BingSun YaoyaoYue Weihua - Neuropsychiatric symptoms in dementia (NPS) are common and among the most troubling aspects of living with dementia, yet their underlying mechanisms remain unclear. Here, we aimed to identify cerebrospinal fluid (CSF) proteins associated with NPS. - Source: PubMed
Publication date: 2026/06/30
Mei ZhenHoward NicholasHarvey Danielle J Fox EdwardSeyfried Nicholas TWingo Thomas SWingo Aliza P - The preBötzinger Complex is among the few neural circuits where selective elimination of defined neuronal subpopulation is sufficient to destabilize a core autonomic function and can fatally impair breathing. Within this circuitry, neurons expressing the neurokinin-1 receptor () and somatostatin () are critical subpopulations; neurons respond to the neuropeptide substance P and are necessary for maintaining inspiratory rhythms, and ablation of neurons results in apneas. To further dissect and analyze the specific roles for and cell types, we conducted a comprehensive transcriptomic analysis using single-nucleus RNA sequencing of enriched preBötC from neonatal C57BL/6J mice. Because respiratory rhythmogenesis is an inherently electrophysiological process, we focused on the ion channel transcriptomes of Tacr1 + and Sst+ populations to resolve the molecular underpinnings of their distinct contributions to breathing. A balanced Random Forest classifier distinguished Tacr1 from Sst neurons with higher accuracy, indicating a distinct and relatively homogeneous ion channel identity in Tacr1 neurons. Differential expression analyses identified coordinated upregulation of , and genes in Tacr1 neurons. Tacr1 neurons further exhibited elevated expression of the NALCN channelosome subunits and selective enrichment genes of and neuromodulatory receptor genes. Together, these findings define a molecularly distinct ion channel composition of Tacr1 neurons and imply convergent substance P linked mechanisms: TRPC5-mediated I and NALCN-mediated sodium leak conductance supporting rhythmic inspiratory activity, providing a molecular framework for targeted interrogation of respiratory circuit function. - Source: PubMed
Publication date: 2026/07/02
Bhagavan HemalathaWei Aguan DOliveira Luiz MRamirez Jan-Marino - Tooth agenesis is a genetically heterogeneous developmental anomaly in which disturbances of morphogen signaling, cytoskeletal organization, and mineralization converge during odontogenesis. Building on a previously published clinical and exome study of two Lebanese families with familial nonsyndromic tooth agenesis that identified rare segregating missense variants in trio Rho guanine nucleotide exchange factor (TRIO) and calcium voltage-gated channel auxiliary subunit alpha2delta 2 (CACNA2D2), this work examines how these genes may participate in a shared mechanistic axis during human tooth development. - Source: PubMed
Publication date: 2026/05/25
Nabbout FideleSabbagh JosephEl Hajj JoelleGhassibe Michella - The progression of lung adenocarcinoma (LUAD) is influenced by polyamine metabolism, which modulates antitumor immunity, although the underlying mechanisms remain unclear. The present study investigates the role of polyamine metabolism-related genes (PMRGs) in LUAD using transcriptomic data, single-cell RNA sequencing (scRNA-seq) and Mendelian randomization. Differentially expressed PMRGs were identified through differential expression analysis and weighted gene co-expression network analysis. Prognostic genes were selected via Cox regression and least absolute shrinkage and selection operator regression to construct a risk model. Immune infiltration, machine learning and scRNA-seq were employed to explore molecular mechanisms whilst reverse transcription-quantitative PCR (RT-qPCR) validated gene expression in LUAD tissues. A nomogram incorporating risk scores assisted in predicting LUAD prognosis (area under the curve >0.6). Distinct immune cell profiles, particularly involving B cells and CD4 T cells, were observed between high- and low-risk groups. Drug sensitivity analysis identified 15 drugs with differential responses. Epithelial cells emerged as a key cluster, with dynamic changes in calcium voltage-gated channel auxiliary subunit α2δ2 (CACNA2D2) expression during pseudotime. RT-qPCR confirmed the downregulation of prognostic genes in LUAD. A polyamine metabolism-related prognostic signature (CACNA2D2, adenoreceptor β-1, immunoglobulin superfamily member 10 and carbonic anhydrase 4) associated with the tumor microenvironment was established, offering potential for enhanced prognosis prediction in LUAD. - Source: PubMed
Publication date: 2026/05/21
Yang HuaZhang LemengChen JianhuaZhang Junjie