NME4 polyclonal antibody
- Known as:
- NME4 pab (anti-)
- Catalog number:
- PAB4030
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- NME4 polyclonal antibody
Related genes to: NME4 polyclonal antibody
- Gene:
- NME4 NIH gene
- Name:
- NME/NM23 nucleoside diphosphate kinase 4
- Previous symbol:
- -
- Synonyms:
- nm23-H4, NM23H4, NDPKD
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2016-07-15
Related products to: NME4 polyclonal antibody
Related articles to: NME4 polyclonal antibody
- Gastric cancer (GC) exhibits marked epidemiological differences between European (EUR) and East Asian (EAS) populations, with significantly higher incidence rates in EAS. Circulating proteins represent promising drug targets; however, most proteomic studies have focused primarily on EUR ancestry, leaving EAS-specific targets largely underexplored. This study aims to identify ancestry-specific plasma protein targets for GC using Mendelian randomization (MR). - Source: PubMed
Publication date: 2026/05/01
Zhi PengCui YanXue GuanghuiQiao LingyuGeng JieChang ZhengyaoXu YinmeiYan JuanjuanWang YingliZhao Chenghui - The development of circularly polarized luminescence (CPL) emitters with a luminescence dissymmetry factor (|g|) approaching the theoretical limit of 2 remains a central challenge in chiral photonics. Herein, considerable g values (1.48-1.65) were achieved in helicates (NMe)[Eu(R/S-)] (ΔΔ/ΛΛ--) with different structural rigidity, as well as in crown ether-modified (NMe)[Eu(R/S-)] (ΔΔ/ΛΛ-) that exhibits adjustable coordination geometry symmetry. Notably, encapsulating bulkier [NEt] instead of a [NMe] counterion within the inner cavity of ΔΔ/ΛΛ- further elevates |g| to an unprecedented 1.71, the highest value for any chiral molecular emitter. While the NMe-ΔΔ/ΛΛ- achieves an ultrahigh CPL brightness (B = 3625 M cm), resulting from its large g value (1.63) and high quantum yield (Φ = 32%). Structural and spectroscopic analyses demonstrate that the high CPL activity originates from a conformationally rigidified square antiprismatic (SAP) geometry around the Eu(III) center. This structure and property relationship is vividly demonstrated by the crown-ether-functionalized ΔΔ-, where gradual binding of Cs ions triggers a pronounced g fluctuation (1.48 → 0.62 → 1.41) through a perturbation and subsequent restoration of the SAP environment. Furthermore, the multicrown-ether binding sites in ΔΔ- enable cooperative guest binding, facilitating the first naked-eye CPL recognition of the antispasmodic drug tizanidine. This work establishes rigidifying SAP configuration as a general design principle for maximizing the CPL activity of lanthanide complexes and opening avenues for advanced CPL applications. - Source: PubMed
Publication date: 2026/04/15
Huang WenruYao ZhiweiYin SenGao TingCrassous JeanneZhou YanyanLi Hongfeng - This study aimed to comprehensively characterize the relationship between glycated hemoglobin (HbA1c) and intervertebral disc degeneration (IVDD) by integrating population-level epidemiological profiling, Mendelian randomization (MR) analysis, multi-omics data, and single-cell transcriptomics. The objectives included clarifying the causal effect of HbA1c on IVDD, identifying key HbA1c-related genes, elucidating their cellular and molecular roles in disc degeneration, and exploring potential therapeutic targets. Global Burden of Disease (GBD) 2021 database was used to evaluate the incidence rate of diabetes mellitus (DM) and low back pain (LBP) across the entire global population. To assess the causal effect of HbA1c on IVDD, MR approache was conducted using summary statistics from large genome-wide association studies. Subsequently, integrating cis-eQTL information, bulk RNA sequencing, and single-cell RNA sequencing were performed to identify HbA1c-related genes involved in disc degeneration, and explore their roles along pseudotime differentiation trajectories. Potential associations between hub genes and IVDD, as well as candidate therapeutic compounds targeting these genes, were further evaluated through database screening and molecular docking. The findings from GBD indicated a correlation between diabetes and low back pain in both 1990 and 2021. The results of MR analysis revealed a causal relationship between HbA1c levels and IVDD. After integrated analysis of the eQTLGen database and RNA-seq data, we identified five hub HRGs, including STAT5A, CDKN1C, TRPS1, NME4, and OASL, which have been implicated in multiple biological processes and pathways associated with IVDD. Moreover, the scRNA-seq analysis showed that hub HRGs were associated with specific cell subpopulations in human nucleus pulposus (NP) tissues, such as inflamed chondrocytes, fibrochondrocytes, chondrocytes, and calcifying chondrocytes. Additionally, hub HbA1c related genes (HRGs) have been found to be associated with several DDDs such as back pain, osteoporosis, and spinal stenosis. Meanwhile, 12 drugs, including resveratrol, dexamethasone, and simvastatin, were identified that have the potential to target hub HRGs. This study revealed a causal effect of HbA1c on IVDD and identified five key HbA1c-related genes (STAT5A, CDKN1C, TRPS1, NME4, and OASL) involved in disc degeneration, providing potential targets for future research. - Source: PubMed
Publication date: 2026/03/27
Li ZhonghuiMa WeibangSun LingzhiGuo JiajieZhuang YongNing XuSun HongLiu Miao - Clear cell renal cell carcinoma (ccRCC) is a common and aggressive malignant tumor of the kidney, with a complex pathogenesis involving abnormal expression of multiple genes and signaling pathways. In recent years, the nucleoside diphosphate kinase 4 () gene has garnered increasing attention due to its critical role in cell proliferation, differentiation, and migration. This study aims to investigate the role of in ccRCC and its potential as a biomarker and therapeutic target. - Source: PubMed
Publication date: 2026/01/26
Cheng YanzeXie LinglingLi NingningXu QianZhao YihanYuan ZhifeiMa LiminMeng Wei - RING finger protein 6 (RNF6), a member of the E3 ubiquitin ligase family, has been implicated in various cancers, yet its functional significance and regulatory mechanisms in ovarian cancer (OC) are poorly understood. - Source: PubMed
Publication date: 2026/01/15
Li TaoqiongQian FeiChen YumeiLi Wei