Sycp1 polyclonal antibody (DyLight 549)
- Known as:
- Sycp1 pab (anti-) (DyLight 549)
- Catalog number:
- PAB14964
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- Sycp1 polyclonal antibody (DyLight 549)
Related genes to: Sycp1 polyclonal antibody (DyLight 549)
- Gene:
- ASPM NIH gene
- Name:
- abnormal spindle microtubule assembly
- Previous symbol:
- MCPH5
- Synonyms:
- Calmbp1, ASP, FLJ10517, FLJ10549
- Chromosome:
- 1q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-13
- Date modifiied:
- 2016-10-05
- Gene:
- C6orf223 NIH gene
- Name:
- chromosome 6 open reading frame 223
- Previous symbol:
- -
- Synonyms:
- MGC45491
- Chromosome:
- 6p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2007-12-19
- Date modifiied:
- 2016-09-30
- Gene:
- C12orf66 NIH gene
- Name:
- chromosome 12 open reading frame 66
- Previous symbol:
- -
- Synonyms:
- FLJ32549
- Chromosome:
- 12q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-06-19
- Date modifiied:
- 2019-02-18
- Gene:
- ELOF1 NIH gene
- Name:
- elongation factor 1 homolog
- Previous symbol:
- -
- Synonyms:
- MGC4549, ELF1
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-03-25
- Date modifiied:
- 2016-02-10
- Gene:
- EXD3 NIH gene
- Name:
- exonuclease 3'-5' domain containing 3
- Previous symbol:
- -
- Synonyms:
- LOC54932, FLJ20433, mut-7
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 2009-03-04
- Date modifiied:
- 2014-11-19
Related products to: Sycp1 polyclonal antibody (DyLight 549)
Related articles to: Sycp1 polyclonal antibody (DyLight 549)
- Maintenance of genome integrity is essential for cellular homeostasis, and its perturbation leads to tumorigenesis. Here, we uncover an unanticipated somatic role for the synaptonemal complex protein SYCP1, previously regarded as strictly meiosis specific, in a broad spectrum of human cancers including breast cancer. Through integrative genomic, proteomic, and functional analyses, we demonstrate that SYCP1 is aberrantly reexpressed in tumor cells, where it actively promotes DNA damage repair, cell cycle progression, and malignant growth. SYCP1 binds chromatin at regulatory elements and directly controls transcriptional programs governing genome maintenance, including key effectors such as , , , and . Loss of SYCP1 impairs DNA repair kinetics, attenuates tumor cell proliferation and migration, and increases sensitivity to chemotherapeutics cisplatin and gemcitabine. Mechanistically, SYCP1 coimmunoprecipitates with chromatin remodeling complexes and transcription factors SP1 and SP2 and modulates their genomic occupancy and oncogenic transcriptional outputs. Clinically, high SYCP1 expression stratifies patients with poor prognosis and therapy resistance across multiple cancer types. Our findings illuminate a previously unrecognized moonlighting function of SYCP1 in somatic cancer cells and position it as a critical chromatin-associated regulator of genome stability, with implications for biomarker development and therapeutic targeting. - Source: PubMed
Publication date: 2026/07/08
Brennan Louise CGrinchuk Oleg VPachon-Penalba MiguelSou Ieng FFawcett Conor JNogueira Claudia GGuthrie MeganBates Andrew DHine MeganThomaz AmandaFielding Andew BDavies Owen RTee Wee-WeiMcClurg Urszula L - During meiotic prophase I, mammalian spermatocytes must synthesize large amounts of recombination and synapsis proteins despite global transcriptional suppression at the leptotene/zygotene (L/Z) stages. Here, we identify eukaryotic translation elongation factor 1 gamma (eEF1G), highly expressed in spermatogenic cells, as a factor essential for sustaining translation during this transcriptionally quiescent period. Germ cell-specific Eef1g knockout causes complete male infertility due to zygotene arrest, characterized by defects in recombination intermediate stabilization and synapsis. Mechanistically, eEF1G associates with ribosomal proteins, and ribosome profiling reveals increased ribosome occupancy on specific meiotic transcripts in Eef1g-deficient spermatocytes. Quantitative proteomics further reveals selective depletion of synapsis-related (e.g., SYCP1, SYCE1) and recombination-related proteins (e.g., MSH4, TEX11). Together, these findings demonstrate that eEF1G is required to maintain efficient protein production during the transcriptionally quiescent leptotene/zygotene stages, thereby supporting proper meiotic progression in mammalian spermatocytes. - Source: PubMed
Publication date: 2026/07/01
Xu JianzeHu YuweiLu XukunCai YulingLi TongtongGao MingMa JinlongGao YuanLiu ShangmingChen Zi-JiangMeng JingLiu HongbinJiang Xiaohua - The initiation of meiosis in the female germline of mammals is a gradual process, but there is currently no clear quantitative framework for determining the precise timing of its onset. Here, we attempt to standardize the description of meiotic entry timing through a systematic, quantitative analysis of meiotic entry and progression in the mouse fetal ovary. Using dynamic expression profiling of key regulators Stra8, Sycp1, and Sycp3 alongside proliferation markers, we demonstrate that germ cells enter meiosis asynchronously and continuously between embryonic days E12.5 and E16.5. During this extended period, mitotic proliferation persists, indicating that germ cells are progressively recruited into the meiotic pathway rather than halting division simultaneously. Homologous chromosome synapsis, marked by Sycp1/Sycp3 co-localization, initiates at E14.5 and is completed prenatally by E18.5. Using stage-composition data, we constructed a continuous-time Markov chain model to infer a population-level meiotic stage clock. This model estimates approximately conserved population-level effective intervals from the modeled early-prophase L compartment to pachytene-stage synapsis (∼72 h) and to the late-prophase/dictyate-associated D-state transition (∼91 h) across modeled cohort-start times. Our findings refine the conventional view by quantitatively defining the extended window of meiotic entry and subsequent progression through prophase I. - Source: PubMed
Publication date: 2026/06/15
Jin ZiyiLiu ChangLiu GanFeng GuofengLi JieWu YiweiJia HaoKeefe David LLiu Lin - Busulfan (Bus)-induced oligozoospermia still lacks a disease-modifying therapy, and its pathogenesis has been largely attributed to germ-cell DNA damage. Emerging evidence indicates that microbiota-derived metabolites are key determinants of spermatogenic failure. Saikosaponin A (SSA), a major triterpenoid from Bupleurum, has never been evaluated in male infertility. Consequently, its regulatory role in the gut microbiota-metabolite axis and causal efficacy remain completely undefined. - Source: PubMed
Publication date: 2026/06/09
Li YaqiuZhang BoqiHe GuitianShen CaomeihuiChang FuqiangYang JunjunWang SihuiWang YueyingZong JinxinLuo YuxinWang NanSun YananSui YueWu MengtingLu DongjinLi ChunjinZhou Xu - The synaptonemal complex (SC) is a highly ordered proteinaceous structure that assembles between homologous chromosomes during the prophase I of meiosis. Conserved as a tripartite architecture across species, the SC plays a central role in chromosome synapsis, meiotic recombination, and faithful chromosome segregation. This review marks the 70th anniversary of the discovery of the synaptonemal complex by Montrose Moses in 1956. In mammals, the SC is composed of eight core (canonical) structural proteins: SYCP1, SYCP2, SYCP3, SYCE1, SYCE2, SYCE3, SIX6OS1, and TEX12. The archetypal SC consists of two lateral elements (SYCP2 and SYCP3), a central element (SYCE1/2/3, SIX6OS1, and TEX12), and numerous transverse filaments (SYCP1). A shared structural feature of SC components is the presence of coiled-coil domains. Although the tripartite organization of the SC is evolutionarily conserved, its constituent proteins exhibit little to no sequence homology across species. In addition to these core components, a number of proteins, including HORMAD1, HORMAD2, TRIP13, SKP1, CDCA5 (Sororin), UBE2I (UBC9), SYCP2L, HSPA2, PSMA8, and FKBP6, associate with the SC. Beyond serving as a structural scaffold essential for homolog synapsis, SC proteins interact with key recombination factors such as DMC1, RAD51, and TEX11, thereby regulating recombination progression and crossover formation. Genetic, biochemical, and structural analyses of SC components have provided important mechanistic insights into SC assembly and function, as well as their clinical relevance to non-obstructive azoospermia (NOA) and premature ovarian insufficiency (POI) in humans. - Source: PubMed
Publication date: 2026/04/30
Yang FangWang P Jeremy