SYCP1 polyclonal antibody (HRP)
- Known as:
- SYCP1 pab (anti-) (horseradish peroxidase)
- Catalog number:
- PAB14957
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- SYCP1 polyclonal antibody (HRP)
Related genes to: SYCP1 polyclonal antibody (HRP)
- Gene:
- CDC73 NIH gene
- Name:
- cell division cycle 73
- Previous symbol:
- C1orf28, HRPT2, HRPT1
- Synonyms:
- parafibromin, FIHP
- Chromosome:
- 1q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-08
- Date modifiied:
- 2019-04-23
- Gene:
- CYHR1 NIH gene
- Name:
- cysteine and histidine rich 1
- Previous symbol:
- -
- Synonyms:
- CHRP, KIAA0496, MGC13010
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-12-17
- Date modifiied:
- 2016-10-05
- Gene:
- FOXO1B NIH gene
- Name:
- forkhead box O1B (pseudogene)
- Previous symbol:
- FKHRP1
- Synonyms:
- -
- Chromosome:
- 5q35.3
- Locus Type:
- pseudogene
- Date approved:
- 1998-03-23
- Date modifiied:
- 2018-10-24
- Gene:
- HDGFL1 NIH gene
- Name:
- HDGF like 1
- Previous symbol:
- PWWP1
- Synonyms:
- dJ309H15.1, Hdgfrp1, HRP-1
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-20
- Date modifiied:
- 2017-03-24
- Gene:
- HDGFL2 NIH gene
- Name:
- HDGF like 2
- Previous symbol:
- -
- Synonyms:
- HRP2, Hdgfrp2
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2017-04-21
- Date modifiied:
- 2017-04-21
Related products to: SYCP1 polyclonal antibody (HRP)
Related articles to: SYCP1 polyclonal antibody (HRP)
- During meiotic prophase I, mammalian spermatocytes must synthesize large amounts of recombination and synapsis proteins despite global transcriptional suppression at the leptotene/zygotene (L/Z) stages. Here, we identify eukaryotic translation elongation factor 1 gamma (eEF1G), highly expressed in spermatogenic cells, as a factor essential for sustaining translation during this transcriptionally quiescent period. Germ cell-specific Eef1g knockout causes complete male infertility due to zygotene arrest, characterized by defects in recombination intermediate stabilization and synapsis. Mechanistically, eEF1G associates with ribosomal proteins, and ribosome profiling reveals increased ribosome occupancy on specific meiotic transcripts in Eef1g-deficient spermatocytes. Quantitative proteomics further reveals selective depletion of synapsis-related (e.g., SYCP1, SYCE1) and recombination-related proteins (e.g., MSH4, TEX11). Together, these findings demonstrate that eEF1G is required to maintain efficient protein production during the transcriptionally quiescent leptotene/zygotene stages, thereby supporting proper meiotic progression in mammalian spermatocytes. - Source: PubMed
Publication date: 2026/07/01
Xu JianzeHu YuweiLu XukunCai YulingLi TongtongGao MingMa JinlongGao YuanLiu ShangmingChen Zi-JiangMeng JingLiu HongbinJiang Xiaohua - The initiation of meiosis in the female germline of mammals is a gradual process, but there is currently no clear quantitative framework for determining the precise timing of its onset. Here, we attempt to standardize the description of meiotic entry timing through a systematic, quantitative analysis of meiotic entry and progression in the mouse fetal ovary. Using dynamic expression profiling of key regulators Stra8, Sycp1, and Sycp3 alongside proliferation markers, we demonstrate that germ cells enter meiosis asynchronously and continuously between embryonic days E12.5 and E16.5. During this extended period, mitotic proliferation persists, indicating that germ cells are progressively recruited into the meiotic pathway rather than halting division simultaneously. Homologous chromosome synapsis, marked by Sycp1/Sycp3 co-localization, initiates at E14.5 and is completed prenatally by E18.5. Using stage-composition data, we constructed a continuous-time Markov chain model to infer a population-level meiotic stage clock. This model estimates approximately conserved population-level effective intervals from the modeled early-prophase L compartment to pachytene-stage synapsis (∼72 h) and to the late-prophase/dictyate-associated D-state transition (∼91 h) across modeled cohort-start times. Our findings refine the conventional view by quantitatively defining the extended window of meiotic entry and subsequent progression through prophase I. - Source: PubMed
Publication date: 2026/06/15
Jin ZiyiLiu ChangLiu GanFeng GuofengLi JieWu YiweiJia HaoKeefe David LLiu Lin - Busulfan (Bus)-induced oligozoospermia still lacks a disease-modifying therapy, and its pathogenesis has been largely attributed to germ-cell DNA damage. Emerging evidence indicates that microbiota-derived metabolites are key determinants of spermatogenic failure. Saikosaponin A (SSA), a major triterpenoid from Bupleurum, has never been evaluated in male infertility. Consequently, its regulatory role in the gut microbiota-metabolite axis and causal efficacy remain completely undefined. - Source: PubMed
Publication date: 2026/06/09
Li YaqiuZhang BoqiHe GuitianShen CaomeihuiChang FuqiangYang JunjunWang SihuiWang YueyingZong JinxinLuo YuxinWang NanSun YananSui YueWu MengtingLu DongjinLi ChunjinZhou Xu - The synaptonemal complex (SC) is a highly ordered proteinaceous structure that assembles between homologous chromosomes during the prophase I of meiosis. Conserved as a tripartite architecture across species, the SC plays a central role in chromosome synapsis, meiotic recombination, and faithful chromosome segregation. This review marks the 70th anniversary of the discovery of the synaptonemal complex by Montrose Moses in 1956. In mammals, the SC is composed of eight core (canonical) structural proteins: SYCP1, SYCP2, SYCP3, SYCE1, SYCE2, SYCE3, SIX6OS1, and TEX12. The archetypal SC consists of two lateral elements (SYCP2 and SYCP3), a central element (SYCE1/2/3, SIX6OS1, and TEX12), and numerous transverse filaments (SYCP1). A shared structural feature of SC components is the presence of coiled-coil domains. Although the tripartite organization of the SC is evolutionarily conserved, its constituent proteins exhibit little to no sequence homology across species. In addition to these core components, a number of proteins, including HORMAD1, HORMAD2, TRIP13, SKP1, CDCA5 (Sororin), UBE2I (UBC9), SYCP2L, HSPA2, PSMA8, and FKBP6, associate with the SC. Beyond serving as a structural scaffold essential for homolog synapsis, SC proteins interact with key recombination factors such as DMC1, RAD51, and TEX11, thereby regulating recombination progression and crossover formation. Genetic, biochemical, and structural analyses of SC components have provided important mechanistic insights into SC assembly and function, as well as their clinical relevance to non-obstructive azoospermia (NOA) and premature ovarian insufficiency (POI) in humans. - Source: PubMed
Publication date: 2026/04/30
Yang FangWang P Jeremy - Meiotic recombination plays a crucial role in the correct separation of homologous chromosomes. The DNA mismatch repair protein Msh4 is a meiosis specific protein and msh4 defects were reported to associate with azoospermia and ovarian dysfunction in mammal. However, its role has not been elucidated in an important model animal, zebrafish. Here, we examined the role of Msh4 in meiosis and gametogenesis by knocking out msh4 using CRISPR/Cas9 technology. The resultant msh4 mutants showed male predominance (98.5%) and brought asynaptic meiosis to form unpaired univalents evidenced by the immunofluorescence detection of the synaptonemal complex protein Sycp3 and Sycp1, and the recombination protein Rad51. Such unusual meiotic configurations led to meiotic arrest and subsequent abortive spermatogenesis. In contrast, msh4 deficiency induced infrequent msh4 female (1.5%) that laid eggs which developed to normal (40-80%) or abnormal (20-60%) progeny by fertilizing with sperm of wild type. Thus, Msh4 is essential for the meiosis in males, but is not strictly required in females. - Source: PubMed
Publication date: 2026/02/26
Guo YankunZhang YunbangMei YihuiHuang YuweiZheng YuxuanZhang NanJiang YuxinJiang HanjunZhang ZijieLi AngxiaoFan JinchangArai KatsutoshiGao JianCao Xiaojuan