Klf4 monoclonal antibody
- Known as:
- Klf4 mab (anti-)
- Catalog number:
- MAB8725
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- Klf4 monoclonal antibody
Related genes to: Klf4 monoclonal antibody
- Gene:
- KLF4 NIH gene
- Name:
- Kruppel like factor 4
- Previous symbol:
- -
- Synonyms:
- EZF, GKLF
- Chromosome:
- 9q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-14
- Date modifiied:
- 2016-10-05
Related products to: Klf4 monoclonal antibody
Related articles to: Klf4 monoclonal antibody
- Systemic sclerosis (SSc) is a systemic autoimmune disease leading to extensive fibrosis of the skin and many visceral organs, including the lungs. The need for effective treatments is urgent, as none exists today that can stop or reverse the progression of fibrosis. We examined the effect of restoring KLF4 levels in primary human lung fibroblasts of SSc patients with pulmonary fibrosis as a potential therapeutic strategy. - Source: PubMed
Publication date: 2026/05/18
Renaud LudivineKotz SamanthaMenon AravindFeghali-Bostwick Carol - Atherosclerosis preferentially develops at arterial regions exposed to low shear stress (LSS), highlighting the critical role of local hemodynamic forces in disease initiation and progression. Emerging evidence indicates that endothelial lipid metabolism is a key determinant of vascular homeostasis; however, whether LSS directly regulates endothelial lipid droplets' (LDs) dynamics remains unclear. In particular, the mechano-transduction pathways linking shear stress to lysosome-mediated lipid processing within the endothelium have yet to be defined. - Source: PubMed
Publication date: 2026/05/15
Shi YiTan Ya-NanWu Li-DaWang Li-GuoGu YueZhou Wen-YingShao Meng-QianZhang Jun-Xia - Microbiota-derived metabolites are increasingly recognized as modulators of systemic immunity and cancer biology. This study investigates how a structurally distinct lipid from Akkermansia muciniphila influences immune transcriptional programs and their connection to breast cancer (BRCA)-associated pathways. - Source: PubMed
Chaudhary UmaA S AryaA Mythili - Time-restricted feeding (TRF), a circadian-based dietary intervention, has emerged as a promising strategy to counteract metabolic and age-related dysfunctions. However, how TRF can reverse stem cell aging and restore tissue regenerative potential remains unclear. In this study, we investigated the effects of long-term TRF on senescent adipose-derived stem cells (ADSCs) in a high-fat diet (HFD) induced aged mice model. Mice were assigned to standard or HFD diets under ad libitum or TRF (8 h/day) regimens for 7 months. TRF effectively attenuated HFD-induced weight gain and metabolic inflexibility. Functionally, TRF preserved ADSC morphology and mitochondrial integrity, restored proliferation and migration capacity. Restored balanced lineage differentiation and markedly reduced senescence markers, reactive oxygen species, and inflammatory cytokines. TRF was associated with increased expression of Oct4, Sox2, and Klf4 (OSK) in ADSCs. Lentiviral overexpression of OSK partially recapitulated restoration-associated phenotypes in vitro. However, while OSK overexpression was sufficient to induce these changes, the present data do not establish a necessary role for OSK in mediating TRF-induced effects. Analysis of adipose tissue was consistent with the cell assay, confirming that TRF alleviated fibrosis and inflammation in aged adipose tissue. We find TRF as a noninvasive, physiologically safe intervention to restore aged stem cell function and tissue homeostasis during aging. - Source: PubMed
Publication date: 2026/05/25
Zhang RuiDuan XingxiangZhong WanyangDeng YanWang ZipingWang JunnanHe YanRong ShuangYe Qingsong - Despite the relevance of induced pluripotent stem cells (iPSCs) technology for biotechnological applications in cattle, the generation of bona fide bovine iPSCs (biPSCs) remains challenging. This study aimed to evaluate the use of a non-integrating Sendai virus system carrying polycistronic human KLF4-OCT3/4-SOX2, c-MYC, and KLF4 to reprogram bovine fetal mesenchymal stem/stromal cells (MSCs) derived from adipose tissue (AT-MSCs) and bone marrow (BM-MSCs) into biPSCs. - Source: PubMed
Publication date: 2026/05/22
Quiroga BlancaLeiva BarbaraDíaz CarlosMorera Francisco JPaiva LuisTorres Cristian GParraguez Víctor HPeralta Oscar A