DNA3-SURVIVIN C84A Expression Vector
- Known as:
- DNA3-SURVIVIN C84A Expression Vector
- Catalog number:
- 131009
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Ch3biosystems
- Gene target:
- DNA3-SURVIVIN C84A Expression Vector
Related genes to: DNA3-SURVIVIN C84A Expression Vector
- Gene:
- SUN1 NIH gene
- Name:
- Sad1 and UNC84 domain containing 1
- Previous symbol:
- UNC84A
- Synonyms:
- KIAA0810, FLJ12407
- Chromosome:
- 7p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-13
- Date modifiied:
- 2014-11-18
Related products to: DNA3-SURVIVIN C84A Expression Vector
Related articles to: DNA3-SURVIVIN C84A Expression Vector
- Alterations in nuclear envelope proteins such as SUN1 and prelamin A are known hallmarks of cellular aging, but how they cause aging phenotypes beyond the expressing cells is unknown. With a tissue culture version of parabiosis, we found that aged fibroblasts secrete an activity that induces aging-related polarity defects in young fibroblasts. Secretomics identified the factor as apolipoprotein D (ApoD), a circulating protein whose levels are known to rise with age. ApoD increased SUN1 levels and disrupted polarity in fibroblasts via SUN1-promoted coupling of microtubules to the nucleus. In turn, elevated SUN1 enhanced ApoD expression and secretion, forming a feedback loop that promotes acquisition of aged phenotypes. In mice, ApoD induced aging-related phenotypes in muscle. Elevated ApoD expression required coupling between SUN1, its outer nuclear membrane binding partner nesprin-2, and microtubules. Broader analysis revealed that this pathway regulates hundreds of genes. These findings define microtubule-nuclear coupling as a direct mechanotransduction pathway controlling gene expression and promoting aging-associated phenotypes. - Source: PubMed
Publication date: 2026/09/10
Chen MengqiWilson Paige CYang WenyaoMa YueLi YutaoWang XinluanBennett Richard LLicht Jonathan DGundersen Gregg GChang Wakam - Regenerating tissues like the axolotl ( ) limb draw from many cell types, but isolating specific cell populations remains a bottleneck. Standard approaches rely on enzymatic dissociation and fluorescence-activated cell sorting (FACS), which are slow, costly, and require specialized instrumentation. We adapted INTACT (Isolation of N uclei Ta gged in specific C ell T ypes) to the axolotl, generating a transgenic line ( ) expressing in limb connective tissue, the population that carries limb positional information, dedifferentiates following injury, and forms the majority of the regenerative blastema. Combining an optimized nuclei isolation protocol with anti-GFP nanobody capture enriched labeled nuclei from ∼34.6% of input to 80-89% purity. Relative to dissociation and FACS, this recovers roughly 30-fold more target nuclei in less than half the time and without a cytometer. Bead-bound nuclei are directly applied to combinatorial-barcoding snRNA-seq, eliminating fluorescence-activated nuclei sorting (FANS). Profiling INTACT connective tissue during TGFβ inhibition revealed a loss of extracellular matrix remodeling with upregulated pro-fibrotic and inflammatory gene programs, resembling an unresolved wound environment. These changes reverse and regeneration resumes upon drug washout, indicating that functional TGFβ signaling is required for the transition from wound resolution to blastema formation. - Source: PubMed
Publication date: 2026/09/22
Barrett Jacob EAiluri RamyaAmos ZinnCurtis TimRock SamanthaCurrie Joshua D - Nuclear Envelope Membrane Protein 1 (NEMP1) is highly expressed in oocytes and required for fertility, yet its meiotic function remains poorly understood. Here, we identify NEMP1 as a critical organizer of meiotic telomere-nuclear envelope coupling and chromosome dynamics. Loss of NEMP1 causes telomere aggregation, loss of shelterin protection, telomere shortening, persistent DNA damage, aberrant non-homologous end joining, and chromosome end-to-end fusion, ultimately leading to aneuploidy in mouse oocyte. NEMP1 is required during early fetal meiotic prophase I for telomere-nuclear envelope attachment, bouquet formation, homolog pairing, and synapsis. Live cell imaging revealed robust rapid prophase movements in wild-type meiocytes, which were nearly abolished by NEMP1 loss and restored by NEMP1-GFP re-expression. Mechanistically, NEMP1 associates with telomeric DNA and the SUN1-KASH5 LINC machinery, and SUN1-GFP restores chromosome movement in Nemp1-deficient meiocytes. Together, these findings establish NEMP1 as a nuclear-envelope organizer linking telomere protection, chromosome dynamics, and genome integrity during mammalian oogenesis. - Source: PubMed
Publication date: 2026/09/18
Zhang HuiZhang LingPangas StephanieJurisicova AndreaMcNeill Helen - Non-obstructive azoospermia (NOA) with meiotic maturation arrest is a severe form of male infertility for which genetic diagnosis may inform counseling and sperm-retrieval expectations. - Source: PubMed
Publication date: 2026/09/07
Zheng HuimeiWang YunboWang JiaChen WeikangChen JianhuaYang XiaohangJin FanXi YongmeiLi Jingping - Mars undergoes seasonal tidal forcing as a result of its eccentric orbit and the tilt of its rotation axis relative to the Sun. Response to this forcing produces temporal variations in the Martian gravity field and is sensitive to the internal structure of the planet. Using tracking data from the Mars Global Surveyor (MGS), Mars Odyssey (ODY) and Mars Reconnaissance Orbiter (MRO) spacecraft, we demonstrate that degree-3 components of the time-variable gravity field of Mars differ by up to 300% from predictions for a spherically symmetric planet. These deviations can be explained if the effective shear modulus of the mantle varies by >20% over a roughly north-south pattern that closely aligns with the surface expression of the Martian crustal dichotomy. On the basis of this correlation, we infer preservation of a 200-400 °C thermal anomaly in the present-day mantle below the southern highlands of Mars. This temperature variation could reflect regional mantle convection or insulation by the thick southern highlands crust of Mars that has persisted over several billion years. - Source: PubMed
Publication date: 2026/08/26
Berne AlexanderWagner NicholasMatsuyama IsamuGoossens SanderGenova AntonioRovira-Navarro MarcBagheri AmirhosseinQin ChuanMarusiak AngelaHemingway DouglasLau Harriet C PCheng Kar WaiZhong ShijieNimmo Francis