DKK-1 Fc, Human
- Known as:
- DKK-1 Fc, Human
- Catalog number:
- p723-250
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- 101bio
- Gene target:
- DKK-1 Human
Related genes to: DKK-1 Fc, Human
- Gene:
- DKK1 NIH gene
- Name:
- dickkopf WNT signaling pathway inhibitor 1
- Previous symbol:
- -
- Synonyms:
- SK, DKK-1
- Chromosome:
- 10q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-01
- Date modifiied:
- 2018-06-28
Related products to: DKK-1 Fc, Human
Related articles to: DKK-1 Fc, Human
- Ferroptosis therapy holds great potential in metastatic cancer treatment. Whereas, Dickkopf-related protein-1 (DKK1) that highly expressed in various tumors might contribute to low ferroptosis sensitivity of tumor cells, which imposed restrictions on ferroptosis therapy. Our research revealed that DKK1 inhibition could sensitive tumor cells to ferroptosis by obstructing the cystine-GSH-GPX4 axis and the CoQ-FSP1 axis. Moreover, DKK1 inhibition facilitated dormancy of tumor cells, thereby inhibiting their metastatic proliferation. Encouraged by that, a strategy combining DKK1 inhibition with ferroptosis induction was innovatively proposed for metastatic cancer treatment. And a sulfated hyaluronic acid (SHA)-functionalized liposome co-encapsulating DKK1 inhibitor (Gallocyanine) and ferroptosis inducer (RSL3) was developed for this purpose. The constructed SLip/G+R simultaneously targeted primary tumors, circulating tumor cells and tumor metastases by not only binding to P-selectin/CD44 on tumor cells, but also hitchhiking on activated platelets with tumor cells tendency. Particularly, SLip/G+R increased P-selectin/CD44 on tumor cells through DKK1 inhibition, providing more targets for itself and enhancing the targeting effect in a "self-promoting" manner. Due to the self-promoting ferroptosis amplification, SLip/G+R exerted excellent anti-tumor and anti-metastasis efficacy. Overall, this study provided a new idea for efficiently eliminating metastatic tumor cells. It is conducive to promoting the development of ferroptosis therapy, and is of great significance for metastatic cancer treatment. - Source: PubMed
Publication date: 2026/09/02
Guo RongLiu YingkeYin ZhaoruChen ShuangYe YunxiaJi XuxuZhang ZhengkunWang DingxueLi ManLiu Ji - Intervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, imposing a significant economic and physiological burden on individuals and society worldwide. Although dysregulation of the WNT/β-catenin pathway is considered an important factor contributing to the dysfunction of nucleus pulposus (NP) cells and degradation of the extracellular matrix, the mechanisms by which specific subgroups of NP cells are activated and the maintenance of excessive activation of specific pathways remain unclear. - Source: PubMed
Publication date: 2026/08/22
Li QiuweiLiang GuoyanBo KaidaKang LiangJin PeilinZhao ChenhaoZhang RenjieLyu FengjuanShen Cailiang - Secreted modulators of the Wingless (WNT) pathways are associated with cardiometabolic dysregulation. Among these, Dickkopf-1 (DKK1) and secreted frizzled-related protein-3 (sFRP3) are abundantly expressed in placental tissue and secreted into the maternal circulation. We hypothesized their plasma levels would be dysregulated in women with gestational diabetes mellitus (GDM) and correlate with indices of metabolic health. - Source: PubMed
Publication date: 2026/08/14
Ueland ThorMichelsen Annika ElisabetQvigstad ElisabethRoland Marie Cecilie PaascheWesterberg Ane CecilieMichelsen Trond MelbyeAukrust PålBollerslev JensLekva Tove - Following the publication of the above paper, the authors contacted the Editorial Office to explain that they had incorrectly assembled certain of the data included in the western blots featured in Fig. 2D on p. 1033, and wished to issue a corrigendum. Upon performing an independent analysis of the data in this paper in the Editorial Office, however, it came to light that the data in question were strikingly similar to data which had already been submitted to the same journal () in a paper written by different authors at a different research institute. Upon asking the authors for an explanation concerning these data, the authors presented to the office a series of blots related to the same experiments, including the purported integral blots associated with the published data. However, owing to a number of remaining uncertainties concerning the blots provided resulting from an additional assessment of the raw underlying data made using the software analysis program, the Editor of has decided that this paper should be retracted from the Journal on account of a lack of confidence in the originally presented data. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Molecular Medicine 46: 1029‑1038, 2020; DOI: 10.3892/ijmm.2020.4672]. - Source: PubMed
Publication date: 2026/08/28
Liu JunWu MinfeiFeng GuangLi RuiWang YangJiao Jianhang - Semen quality is a critical determinant of reproductive efficiency in poultry, yet its molecular regulation remains poorly understood. - Source: PubMed
Publication date: 2026/08/12
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