Sheep Toll Like Receptor 7 ELISA kit
- Known as:
- Sheep Toll Like Receptor 7 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- e14t0070
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Blue gene shanghai
- Gene target:
- Sheep Toll Like Receptor 7 ELISA kit
Related genes to: Sheep Toll Like Receptor 7 ELISA kit
- Gene:
- TLR4 NIH gene
- Name:
- toll like receptor 4
- Previous symbol:
- -
- Synonyms:
- hToll, CD284, TLR-4, ARMD10
- Chromosome:
- 9q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2016-01-21
Related products to: Sheep Toll Like Receptor 7 ELISA kit
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- Fibromyalgia is a frequently treatment-refractory chronic musculoskeletal pain disorder that often results in clinical depression; however, the role of neuroinflammatory signaling in comorbid depression remains unclear, including the contributions of anti-inflammatory omega-3 fatty acids like eicosapentaenoic acid (EPA). - Source: PubMed
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Publication date: 2026/05/18
Jeong MyeonggukKim YeeunKwon HyeokjinHyun Kyung-YaeKang Do-YoungJang AeleeJu YeongdonChoi Go-Eun - A structurally homogeneous keratan sulfate (KS) was purified from bovine cornea using an optimized method integrating enzymatic digestion and ion-exchange chromatography. Comprehensive structural analyses, including 1D/2D NMR, FT-IR, and disaccharide profiling, demonstrated a highly sulfated, linear polymer composed of repeating [-3Galβ1-4GlcNAcβ1-] units, with predominant 6-O-sulfation on both galactose and N-acetylglucosamine residues, comprising nearly equal proportions of disulfated (Gal6S-GlcNAc6S, 48.63%) and monosulfated (GlcNAc6S, 51.11%) disaccharides, with only trace amounts of non-sulfated units (<0.3%). HPGPC confirmed a narrow molecular weight distribution centered at approximately 43 kDa. Fluorescence quenching spectroscopy demonstrated that KS interacts with collagen with moderate affinity, a 1:1 stoichiometric ratio, and an enthalpy-driven mechanism. Circular dichroism analysis further suggested that KS association induces partial destabilization of the collagen triple-helical structure. At the single-molecule level, fluorescence correlation spectroscopy confirmed the formation of the KS-collagen complex, with further mechanistic insights provided by molecular docking and molecular dynamics simulations. Functionally, KS attenuated LPS-induced pro-inflammatory cytokine expression in RAW 264.7 macrophages, with network pharmacology implicating multi-target regulation of the TLR4/NF-κB pathway. This study establishes a direct link between the fine structure of corneal KS and its biological functions, providing a quantitative framework for understanding stromal matrix organization and guiding KS-based biomaterial design. - Source: PubMed
Publication date: 2026/05/21
Sun YanZhou XinWang YouSong MingzhiZhang LitaoRen Qiang - Repaglinide (RPG) is a commonly prescribed oral antihyperglycemic agent for the control of postprandial hyperglycemia. However, the safety profile of RPG regarding cardiac tissues has not been explored yet. The present study examined the cardiotoxic effects of RPG in male Sprague Dawley rats at different doses using integrated molecular, biochemical, functional and histopathological approaches. Thirty-two rats were randomly allocated to four groups (n = 8), that is, control and RPG-treated (0.7, 1.4, and 4 mg/kg/day) groups for 4 weeks. RPG administration significantly upregulated hypoxia-angiogenic markers (HIF-1α, VEGF-A, VEGFR-2, and EPO) and downregulated ANGPT1, which is suggestive of disrupted vascular stabilization. A strong inflammatory response was noticed with marked activation of TLR4/MyD88/NF-κB signaling and increased COX-2, IL-6, IL-1β, and TNF-α expression. Oxidative stress was markedly increased at a dose-dependent manner, as shown by degradation in antioxidant enzyme (CAT, SOD, GSR, GPx, GST, and HO-1,) and high increments in MDA and ROS levels. Echocardiographic analysis showed a gradual low heart rate, ventricular dilation, thickening of the ventricular walls, and increasing of EDV and ESV, which is a sign of structural remodeling and impairment of the ventricle. Serum cardiac biomarkers (CK-MB, CPK, Troponin-I, Troponin-T, LDH, BNP, NT-proBNP, and CRP) were significantly elevated following the administration of RPG at varying concentrations. Apoptotic signaling was activated significantly as shown by the increased levels of Bax, Caspase-3, and Caspase-9 with reduced expression of Bcl-2 after RPG intoxication. Moreover, RPG exposure induced histopathological alterations including degenerative myocardial lesions, interstitial edema, inflammatory infiltration, and early fibrotic changes. Collectively, these results show that RPG causes profound cardiotoxicity in a dose-dependent manner, mediated by oxidative stress, inflammatory activation, hypoxia-angiogenic imbalance, apoptotic signaling, and structural remodeling. This study demonstrates the importance of thorough cardiovascular safety evaluation of antidiabetic therapies and calls for further translational evaluation to evaluate potential clinical implications. - Source: PubMed
Publication date: 2026/06/02
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