TNFSF13B monoclonal antibody (M19), clone 3G6
- Known as:
- TNFSF13B mab (anti-) (M19), clonality 3G6
- Catalog number:
- H00010673-M19
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- TNFSF13B monoclonal antibody (M19) clone 3G6
Related genes to: TNFSF13B monoclonal antibody (M19), clone 3G6
- Gene:
- AGMO NIH gene
- Name:
- alkylglycerol monooxygenase
- Previous symbol:
- TMEM195
- Synonyms:
- FLJ16237
- Chromosome:
- 7p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2007-11-20
- Date modifiied:
- 2016-10-05
- Gene:
- CCSER1 NIH gene
- Name:
- coiled-coil serine rich protein 1
- Previous symbol:
- FAM190A
- Synonyms:
- KIAA1680
- Chromosome:
- 4q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2009-07-09
- Date modifiied:
- 2015-11-05
- Gene:
- CCSER2 NIH gene
- Name:
- coiled-coil serine rich protein 2
- Previous symbol:
- KIAA1128, FAM190B
- Synonyms:
- -
- Chromosome:
- 10q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-27
- Date modifiied:
- 2015-11-05
- Gene:
- ERICH6 NIH gene
- Name:
- glutamate rich 6
- Previous symbol:
- C3orf44, FAM194A
- Synonyms:
- MGC39662, ERICH6A
- Chromosome:
- 3q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-13
- Date modifiied:
- 2015-11-05
- Gene:
- ERICH6B NIH gene
- Name:
- glutamate rich 6B
- Previous symbol:
- FAM194B
- Synonyms:
- FLJ32682
- Chromosome:
- 13q14.13
- Locus Type:
- gene with protein product
- Date approved:
- 2009-09-08
- Date modifiied:
- 2015-11-05
Related products to: TNFSF13B monoclonal antibody (M19), clone 3G6
Related articles to: TNFSF13B monoclonal antibody (M19), clone 3G6
- Down syndrome (DS), the most prevalent chromosomal disorder caused by trisomy 21, manifests intellectual disability and cognitive dysfunction. Cumulative studies confirm epigenetic pathways including DNA methylation and non-coding RNAs drive DS pathological progression. Histone post-translational modifications (PTMs) are core epigenetic regulators of fetal brain development. However, genome-wide PTM alterations and their downstream functions in fetal DS brains remain poorly characterized, leaving a key gap in revealing epigenetic mechanisms underlying DS neurodevelopmental defects. To address this, we aimed to establish the first comprehensive landscape of histone PTMs in fetal DS cortex and investigate whether specific PTM changes contribute to aberrant neurodevelopmental gene expression. - Source: PubMed
Publication date: 2026/07/30
Ye ShuaiBai BaolingZhao ZhuranWang LiMu QingZhang YangWang XinjuanZhang TingYu WeidongGuo Jingzhu - Acute inflammatory relapses in primary CNS demyelinating diseases, including relapsing multiple sclerosis (RMS), MOG-antibody-associated disease (MOGAD), and neuromyelitis optica spectrum disorder (NMOSD), drive hospitalization, disability, and socioeconomic burden. Blood-based biomarkers are increasingly used for relapse detection and treatment monitoring. - Source: PubMed
Publication date: 2026/09/07
Chumakova Anastasia PDemetriou MichaelSy Michael - Persistent minimal residual disease (MRD) significantly contributes to chemotherapy resistance and relapse in pediatric B-cell acute lymphoblastic leukemia (B-ALL), with conventional clinical risk factors insufficiently explaining the variability in patient prognoses. This study sought to explore potential mechanisms linked to sustained MRD by integrating analyses of clinical cohorts with single-cell transcriptomics, aiming to identify reliable biomarkers for risk stratification and targeted therapy. - Source: PubMed
Publication date: 2026/08/18
Zhang LinlinLiu XiaoyangChen FangXu GangFan Yang - Postoperative delirium (POD) and Alzheimer's disease (AD) are increasingly recognized as related neurocognitive conditions, but the aging-associated cell states that may connect them remain poorly defined. Here, we integrated two brain transcriptomic discovery datasets analyzed at single-cell/single-nucleus resolution, including a POD-related cohort (GSE291019) and an AD cohort (GSE129308), together with two independent peripheral-blood bulk transcriptomic datasets (GSE163943 and GSE63060), to identify aging-associated cellular programs and prioritize convergent molecular candidates. Across 184,168 high-quality cells, inhibitory neurons showed the most consistent aging-associated perturbation across the POD- and AD-related datasets. Re-clustering further identified three inhibitory-neuron subtypes, Inh_Neurons2, Inh_Neurons3, and Inh_Neurons5, with relatively high aging-related gene activity and preferential localization to later pseudotime states. Cross-platform integration of aging-associated inhibitory-neuron genes with a shared bulk DEG set identified four convergent candidates: RGL2, AKT1, SYK, and TNFSF13B. Among them, RGL2 emerged as the leading candidate, with the strongest downstream support concentrated in AD-related analyses. In two-sample Mendelian randomization, genetically predicted higher RGL2 expression was associated with increased AD risk, whereas the estimate for the delirium genome-wide association study proxy used for POD-related analyses was not significant. Pathway analyses further linked higher RGL2 expression to complement/coagulation and innate immune-inflammatory programs in AD-related analyses. These findings suggest a model in which POD and AD may partially intersect through aging-vulnerable inhibitory-neuron states and identify RGL2 as a prioritized candidate for downstream mechanistic investigation. - Source: PubMed
Publication date: 2026/08/29
Fan WeiHan ShuaiWang CunjingGao Ju - Epstein-Barr virus-associated gastric cancer (EBVaGC) is a distinct molecular subtype of gastric cancer, but reliable biomarkers linking EBV-related biology, prognosis, and microenvironmental remodeling remain limited. - Source: PubMed
Jin LufeiJiang ManPan YubinWang YanZhang LeiChen Wujie