NR1D1 monoclonal antibody (M19A), clone 2A5
- Known as:
- NR1D1 mab (anti-) (M19A), clonality 2A5
- Catalog number:
- H00009572-M19A
- Product Quantity:
- 200 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- NR1D1 monoclonal antibody (M19A) clone 2A5
Related genes to: NR1D1 monoclonal antibody (M19A), clone 2A5
- Gene:
- NR1D1 NIH gene
- Name:
- nuclear receptor subfamily 1 group D member 1
- Previous symbol:
- THRAL
- Synonyms:
- ear-1, hRev, Rev-ErbAalpha, THRA1, REVERBA, REVERBalpha
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-16
- Date modifiied:
- 2018-02-14
- Gene:
- TAFA1 NIH gene
- Name:
- TAFA chemokine like family member 1
- Previous symbol:
- FAM19A1
- Synonyms:
- TAFA-1
- Chromosome:
- 3p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-17
- Date modifiied:
- 2019-01-14
- Gene:
- TAFA2 NIH gene
- Name:
- TAFA chemokine like family member 2
- Previous symbol:
- FAM19A2
- Synonyms:
- TAFA-2
- Chromosome:
- 12q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-17
- Date modifiied:
- 2019-01-14
- Gene:
- TAFA3 NIH gene
- Name:
- TAFA chemokine like family member 3
- Previous symbol:
- FAM19A3
- Synonyms:
- TAFA-3
- Chromosome:
- 1p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-17
- Date modifiied:
- 2019-01-14
- Gene:
- TAFA4 NIH gene
- Name:
- TAFA chemokine like family member 4
- Previous symbol:
- FAM19A4
- Synonyms:
- TAFA-4
- Chromosome:
- 3p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-17
- Date modifiied:
- 2019-01-14
Related products to: NR1D1 monoclonal antibody (M19A), clone 2A5
Related articles to: NR1D1 monoclonal antibody (M19A), clone 2A5
- Triptolide demonstrates potent antiarthritic effects in rheumatoid arthritis (RA), although its complete mechanism is not fully elucidated. This study aimed to systematically identify its core targets and regulatory pathways by integrating network pharmacology, molecular docking, and experimental validation. - Source: PubMed
Ren ConglinLi MingshuangHe CaijianLi KuanglinYang Huanhong - Patients with sepsis exhibit circadian disruption and persistent immunosuppression. However, the molecular mechanisms linking them remain unclear. Integration of multi-cohort transcriptomic and single-cell datasets shows that circadian gene dysregulation in patients with sepsis and septic mice correlates with disease severity and immunosuppressive states, with monocytes/macrophages emerging as a principal affected population. Sustained endotoxin stimulation elevates the core clock repressor NR1D1 in macrophages, which occupies the Igf2bp2 promoter and suppresses its transcription. Loss of IGF2BP2 destabilizes the V-ATPase subunit transcripts Atp6v1b2 and Atp6v0c through an mA-dependent mechanism, disrupting phagolysosomal acidification rhythms and pathogen clearance. siRNA-mediated NR1D1 knockdown restores IGF2BP2 expression, circadian oscillations, and phagolysosomal function during the development of endotoxin tolerance. To achieve therapeutic delivery, we engineer hybrid membrane nanovesicles (siNR1D1@HM-LNP) that reverse circadian and immune dysregulation in septic mice, enhance bacterial clearance, and markedly improve survival. These findings establish an NR1D1-mediated circadian-immune coupling mechanism and provide a therapeutic strategy for targeting sepsis-induced immunosuppression. - Source: PubMed
Publication date: 2026/08/24
Chen LangLin WenyiJiang LangGao XuehuiYu ChenyanHan JiliLiu ZhenpingLi XuefengHe MeiLi ChangLi QilanSong ChaoyingXu JiqianShang You - Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba is a traditional Tibetan medicine that has long been used in China for its cardioprotective, Qi-tonifying, and mind-calming properties. It is traditionally indicated for conditions such as irritability, restlessness, and agitation. Among its major active constituents are two naturally occurring small-molecule phenols-salidroside (SAL) and its aglycone tyrosol (TYR). While SAL has been reported to exert neuropsychiatric effects including anxiolytic activity, the underlying mechanisms remain incompletely understood, and whether TYR shares similar anxiolytic properties has yet to be clarified. - Source: PubMed
Publication date: 2026/08/19
Cui JunboJia ChunxueWang ZixinSun YuhanLiang YuluLiu ChuanxinHuang Jianmei - Succinate (SUC), a dietary feed additive, is known to influence muscle fiber structure and lipid metabolism, thereby enhancing meat quality in livestock. This study evaluated the effects of SUC supplementation on growth performance, meat quality, muscle fiber morphology, and transcriptomic profiles of the liver and longissimus thoracis (LT) muscle in Tan sheep. Thirty 5-month-old male Tan sheep (31.48 ± 0.25 kg) were randomly allocated to three dietary treatments ( = 10 per group): control (CON) group (basal diet), SUC1 group (basal diet + 1.0% SUC), and SUC2 group (basal diet + 2.0% SUC). The trial lasted for 60 d. During d 1 to 15, adding SUC to the diet linearly increased average daily gain (ADG) ( = 0.003) and dry matter intake (DMI) ( < 0.001). During d 46 to 60, both ADG ( = 0.002) and DMI ( < 0.001) increased linearly. Over the overall period, DMI increased linearly ( < 0.001), and the feed to gain ratio (F/G) decreased linearly ( < 0.001). Carcass weight ( < 0.001) and dressing percentage ( = 0.004) increased linearly with SUC inclusion. Meat quality improved in both SUC groups, with significantly lower shear force ( = 0.004) and cooking loss ( < 0.001), and higher intramuscular fat (IMF) ( = 0.004) content and LT redness (a∗) value ( = 0.036). Succinate supplementation reduced muscle fiber diameter and cross-sectional area of type I and IIa fibers, while increasing type I and IIa fiber density ( < 0.05). Transcriptomic analyses revealed that SUC altered the expression of genes involved in muscle development, fiber-type transition, lipid metabolism, and circadian rhythm in both liver and LT tissues. Notably, the circadian rhythm pathway was enriched in both tissues, with differential expression of , , and . Molecular docking demonstrated strong binding affinity of SUC to NPAS2 via stable hydrogen bonding, suggesting regulatory roles in circadian and muscle-related pathways. In conclusion, dietary SUC promotes metabolic and muscular adaptations in Tan sheep, improving feed efficiency and meat quality. Under the conditions of this experiment, considering growth performance, feed efficiency, and meat quality, a 1% dietary inclusion of SUC appears to be a practical optimum. - Source: PubMed
Publication date: 2026/07/03
Ren WenyiZhang NingCheng YuchenYang ShuangmingLiu XiaonvLiu MiaoKong WeihaoXu XiaofengZhang Lili - Calcium oxalate (CaOx) kidney stone disease is common and highly recurrent, but the upstream mechanisms that predispose renal tubules to crystal deposition remain unclear. This study investigated whether disruption of environmental light-dark cycles promotes CaOx crystal deposition through NR1D1-dependent metabolic and redox regulation. Mouse models of light-cycle disruption were established with or without glyoxylate-induced hyperoxaluria, and NR1D1-deficient mice were used for in vivo validation. Oxalate-injured HK-2 cells were used for pharmacological and genetic experiments. Transcriptomics, histology, biochemical assays, ROS and mitochondrial membrane potential analyses, crystal adhesion assays, ChIP-qPCR, and dual-luciferase reporter assays were performed. Disrupted lighting conditions promoted renal CaOx crystal deposition and further exacerbated glyoxylate-induced crystal accumulation, accompanied by tubular injury, oxidative stress, reduced antioxidant capacity, and altered circulating insulin and melatonin levels. NR1D1 expression was suppressed, whereas IRS1 signaling and crystal adhesion-related proteins were increased. SR9009 treatment and NR1D1 overexpression alleviated oxalate-induced mitochondrial dysfunction, ROS accumulation, and crystal adhesion, whereas NR1D1 deficiency aggravated renal injury in vivo. Mechanistically, NR1D1 directly bound the IRS1 promoter and repressed IRS1 transcription, thereby preserving FOXO1/GPX4-mediated antioxidant defense. These findings identify an NR1D1-IRS1-FOXO1/GPX4 axis linking light-cycle disruption and circadian-associated dysregulation to oxidative tubular injury and CaOx crystal deposition. - Source: PubMed
Publication date: 2026/08/14
Gao ShunyuHuang KeWan SichengWang JiaWang JiahaoBai Yunjin