NR1D1 monoclonal antibody (M16), clone 1F4
- Known as:
- NR1D1 mab (anti-) (M16), clonality 1F4
- Catalog number:
- H00009572-M16
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- NR1D1 monoclonal antibody (M16) clone 1F4
Related genes to: NR1D1 monoclonal antibody (M16), clone 1F4
- Gene:
- ANO1 NIH gene
- Name:
- anoctamin 1
- Previous symbol:
- ORAOV2, TMEM16A
- Synonyms:
- TAOS2, FLJ10261, DOG1
- Chromosome:
- 11q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-16
- Date modifiied:
- 2016-10-05
- Gene:
- ANO2 NIH gene
- Name:
- anoctamin 2
- Previous symbol:
- C12orf3, TMEM16B
- Synonyms:
- -
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2000-08-24
- Date modifiied:
- 2016-10-04
- Gene:
- ANO3 NIH gene
- Name:
- anoctamin 3
- Previous symbol:
- C11orf25, TMEM16C
- Synonyms:
- GENX-3947, DYT23
- Chromosome:
- 11p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2019-02-28
- Gene:
- ANO4 NIH gene
- Name:
- anoctamin 4
- Previous symbol:
- TMEM16D
- Synonyms:
- FLJ34221, FLJ34272, FLJ35277
- Chromosome:
- 12q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-17
- Date modifiied:
- 2016-10-04
- Gene:
- ANO5 NIH gene
- Name:
- anoctamin 5
- Previous symbol:
- TMEM16E, LGMD2L
- Synonyms:
- GDD1
- Chromosome:
- 11p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-07
- Date modifiied:
- 2019-04-23
Related products to: NR1D1 monoclonal antibody (M16), clone 1F4
Related articles to: NR1D1 monoclonal antibody (M16), clone 1F4
- Chronic kidney disease (CKD) is driven by inflammation, fibrosis, and metabolic dysfunction. While circadian rhythm dysregulation is well documented in chronic disorders, its specific impact on CKD pathogenesis remains elusive. - Source: PubMed
Publication date: 2026/09/06
Li Xiao-QianCheng LeiChen Tian-FenMa Yi-NuoLi Xiao-HuiFu Ting-YuXiao JingZhao Zhan-Zheng - Epileptic seizures exhibit distinct circadian rhythms. Disruption of this rhythm creates a vicious cycle that further exacerbates the seizures. Rev-Erbα is a key circadian regulator that plays a significant role in epilepsy. In this study we aimed to investigate the expression and effects of Rev-Erbα and its agonist SR9009 across different brain regions during acute status epilepticus (SE) and chronic epilepsy (CE). - Source: PubMed
Jiang XueningWu WenjuanYang ZhitangMeng Cancan - Triptolide demonstrates potent antiarthritic effects in rheumatoid arthritis (RA), although its complete mechanism is not fully elucidated. This study aimed to systematically identify its core targets and regulatory pathways by integrating network pharmacology, molecular docking, and experimental validation. - Source: PubMed
Ren ConglinLi MingshuangHe CaijianLi KuanglinYang Huanhong - Patients with sepsis exhibit circadian disruption and persistent immunosuppression. However, the molecular mechanisms linking them remain unclear. Integration of multi-cohort transcriptomic and single-cell datasets shows that circadian gene dysregulation in patients with sepsis and septic mice correlates with disease severity and immunosuppressive states, with monocytes/macrophages emerging as a principal affected population. Sustained endotoxin stimulation elevates the core clock repressor NR1D1 in macrophages, which occupies the Igf2bp2 promoter and suppresses its transcription. Loss of IGF2BP2 destabilizes the V-ATPase subunit transcripts Atp6v1b2 and Atp6v0c through an mA-dependent mechanism, disrupting phagolysosomal acidification rhythms and pathogen clearance. siRNA-mediated NR1D1 knockdown restores IGF2BP2 expression, circadian oscillations, and phagolysosomal function during the development of endotoxin tolerance. To achieve therapeutic delivery, we engineer hybrid membrane nanovesicles (siNR1D1@HM-LNP) that reverse circadian and immune dysregulation in septic mice, enhance bacterial clearance, and markedly improve survival. These findings establish an NR1D1-mediated circadian-immune coupling mechanism and provide a therapeutic strategy for targeting sepsis-induced immunosuppression. - Source: PubMed
Publication date: 2026/08/24
Chen LangLin WenyiJiang LangGao XuehuiYu ChenyanHan JiliLiu ZhenpingLi XuefengHe MeiLi ChangLi QilanSong ChaoyingXu JiqianShang You - Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba is a traditional Tibetan medicine that has long been used in China for its cardioprotective, Qi-tonifying, and mind-calming properties. It is traditionally indicated for conditions such as irritability, restlessness, and agitation. Among its major active constituents are two naturally occurring small-molecule phenols-salidroside (SAL) and its aglycone tyrosol (TYR). While SAL has been reported to exert neuropsychiatric effects including anxiolytic activity, the underlying mechanisms remain incompletely understood, and whether TYR shares similar anxiolytic properties has yet to be clarified. - Source: PubMed
Publication date: 2026/08/19
Cui JunboJia ChunxueWang ZixinSun YuhanLiang YuluLiu ChuanxinHuang Jianmei