NR1D1 monoclonal antibody (M05), clone 5H6
- Known as:
- NR1D1 mab (anti-) (M05), clonality 5H6
- Catalog number:
- H00009572-M05
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- NR1D1 monoclonal antibody (M05) clone 5H6
Related genes to: NR1D1 monoclonal antibody (M05), clone 5H6
- Gene:
- GATAD1 NIH gene
- Name:
- GATA zinc finger domain containing 1
- Previous symbol:
- -
- Synonyms:
- ODAG, RG083M05.2, FLJ22489
- Chromosome:
- 7q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-03-31
- Date modifiied:
- 2019-04-23
- Gene:
- LRRC17 NIH gene
- Name:
- leucine rich repeat containing 17
- Previous symbol:
- -
- Synonyms:
- P37NB, H_RG318M05.3
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-07
- Date modifiied:
- 2014-11-18
- Gene:
- NR1D1 NIH gene
- Name:
- nuclear receptor subfamily 1 group D member 1
- Previous symbol:
- THRAL
- Synonyms:
- ear-1, hRev, Rev-ErbAalpha, THRA1, REVERBA, REVERBalpha
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-16
- Date modifiied:
- 2018-02-14
- Gene:
- TJP1 NIH gene
- Name:
- tight junction protein 1
- Previous symbol:
- -
- Synonyms:
- ZO-1, MGC133289, DKFZp686M05161
- Chromosome:
- 15q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-04-26
- Date modifiied:
- 2016-10-05
Related products to: NR1D1 monoclonal antibody (M05), clone 5H6
Related articles to: NR1D1 monoclonal antibody (M05), clone 5H6
- Leptin regulates metabolism and is modulated by circadian rhythms and light exposure, which is of fundamental importance for Arctic residents living under conditions of extreme photoperiods. This longitudinal study aimed to investigate the association between morning leptin, seasonal circadian light hygiene, and NR1D1 expression in 64 Arctic residents (aged 18‑54 years; 88.7% women) using 7‑day actigraphy, morning leptin and NR1D1 expression. Better circadian light hygiene, measured as normalized blue light exposure amplitude (NA BLE) was associated with lower morning leptin (β = -0.263; p < 0.001), also after adjusting for photoperiod. This association remained significant after controlling for sex, age, and ethnicity (β = -0.171). Later BLE light onset also predicted elevated leptin (β = 0.162; p = 0.031). In non-natives exclusively, reduced NR1D1 expression correlated with higher leptin (β = -0.276; p = 0.026). - Source: PubMed
Publication date: 2026/09/22
Gubin D GKolomeychuk S NBorisenkov M FPetrov I MMarkov A APetrova Yu AVoronin K AMezhakova M SBoldyreva Y VShigabaeva A U - Dinotefuran (DIN) is a widely used neonicotinoid insecticide that has been detected in an increasing number of aquatic environments. However, the sublethal effects of DIN on native fish during their early developmental stages remain to be fully elucidated. The present study evaluated the developmental, behavioral, biochemical and transcriptomic responses of Opsariichthys bidens embryos and larvae exposed to three environmental concentrations of DIN (10, 100 and 1000 ng/L). The results evidenced that exposure to 1000 ng/L DIN resulted in a significant reduction in hatching rate at 48 hpf and a significant increase in larval malformation rate at 96 hpf. Behavioral assays revealed that 120 hpf larvae exposed to 100 and 1000 ng/L DIN exhibited a significant reduction in swimming activity. Transcriptomic analysis revealed that circadian rhythm was one of the most consistently enriched pathways in larvae following DIN exposure, with key clock-related genes including per1a, per3 and nr1d1 affected. Furthermore, DIN has been demonstrated to disrupt neuroendocrine and immune-related biomarkers, as evidenced by a decline in dopamine, GABA and IL-1β in larvae exposed to 1000 ng/L DIN, and a reduction in T3 and T4 in larvae from three DIN exposure groups. WGCNA (weighted gene co-exposure network analysis) proceeded to identify gene modules associated with thyroid hormones, dopamine, hatching rate and locomotor traits. This further highlighted links among circadian regulation, endocrine disruption, calcium signalling and behavioral impairment. Collectively, these findings suggest that early-life DIN exposure disrupts a circadian rhythm-centered neuroendocrine network in O. bidens, providing mechanistic evidence for the ecological risk of neonicotinoids to native freshwater fish. - Source: PubMed
Publication date: 2026/09/08
Xiao Meng-NaDong Mao-MaoDong Shan-ShanDu Xiao-YuChen Xin-XinYang Li-HuaWei Kai-JianMa Xu-Fa - Chronic kidney disease (CKD) is driven by inflammation, fibrosis, and metabolic dysfunction. While circadian rhythm dysregulation is well documented in chronic disorders, its specific impact on CKD pathogenesis remains elusive. - Source: PubMed
Publication date: 2026/09/06
Li Xiao-QianCheng LeiChen Tian-FenMa Yi-NuoLi Xiao-HuiFu Ting-YuXiao JingZhao Zhan-Zheng - Epileptic seizures exhibit distinct circadian rhythms. Disruption of this rhythm creates a vicious cycle that further exacerbates the seizures. Rev-Erbα is a key circadian regulator that plays a significant role in epilepsy. In this study we aimed to investigate the expression and effects of Rev-Erbα and its agonist SR9009 across different brain regions during acute status epilepticus (SE) and chronic epilepsy (CE). - Source: PubMed
Jiang XueningWu WenjuanYang ZhitangMeng Cancan - Triptolide demonstrates potent antiarthritic effects in rheumatoid arthritis (RA), although its complete mechanism is not fully elucidated. This study aimed to systematically identify its core targets and regulatory pathways by integrating network pharmacology, molecular docking, and experimental validation. - Source: PubMed
Ren ConglinLi MingshuangHe CaijianLi KuanglinYang Huanhong