ASSY., PUMP, PERISTALTIC SR10/50
- Known as:
- ASSY., PUMP, PERISTALTIC SR10/50
- Catalog number:
- rvdia03600000016
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Diasource
- Gene target:
- ASSY. PUMP PERISTALTIC SR10/50
Related genes to: ASSY., PUMP, PERISTALTIC SR10/50
- Gene:
- MMP7 NIH gene
- Name:
- matrix metallopeptidase 7
- Previous symbol:
- MPSL1
- Synonyms:
- PUMP-1
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-15
- Date modifiied:
- 2015-08-25
Related products to: ASSY., PUMP, PERISTALTIC SR10/50
0.5 mm 2-pump Connecting Tube0.9 mm 2-pump Connecting Tube1-pump Control Cable, AC-21101-pump Control Cable, AC-21201000UL TRAY ASSY 1ml 60 WELL2-pump Control Cable, AC-21102-pump Control Cable, AC-212023 kDa subunit of V-ATPase,Atp6f,Atp6v0b,Mouse,Mus musculus,Vacuolar proton pump 21 kDa proteolipid subunit,V-ATPase 21 kDa proteolipid subunit,V-type proton ATPase 21 kDa proteolipid subunit32 kDa accessory protein,ATP6D,ATP6V0D1,Bos taurus,Bovine,P39,Vacuolar proton pump subunit d 1,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,V-ATPase subunit d 1,VPATPD,V-type proton ATPase32 kDa accessory protein,ATP6D,ATP6V0D1,Homo sapiens,Human,p39,Vacuolar proton pump subunit d 1,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,V-ATPase subunit d 1,VPATPD,V-type proton ATPaseAC-2110 Perista Pump 1-ch, 110VAC-2110 Perista Pump 1-ch, 230VAC-2110 Perista Pump 2-ch, 110VAC-2110 Perista Pump 2-ch, 230VAC-2120 Perista Pump, 110V Related articles to: ASSY., PUMP, PERISTALTIC SR10/50
- Individuals with Laron syndrome, a rare condition characterized by congenital insulin-like growth factor 1 (IGF-1) deficiency, display a remarkably low incidence of cancer, suggesting the existence of protective mechanisms linking reduced IGF-1 signaling to decreased cancer susceptibility. Consistent with this observation, IGF-1 is a recognized promoter of prostate cancer (PCa) progression, although the underlying mechanisms remain incompletely understood. Methylglyoxal (MG)-derived glycative stress, reflected by the accumulation of MG-derived hydroimidazolone 1 (MG-H1), has been implicated in PCa progression but has never been investigated in Laron syndrome. We found that liver tissues from Laron mice exhibited lower MG-H1 levels, suggesting reduced MG-derived glycative stress associated with low IGF-1 signaling. These findings prompted us to investigate whether MG-derived glycative stress contributes to IGF-1-driven PCa progression. Compared with the less aggressive LNCaP cells, PC3 cells displayed higher basal IGF-1 and MG-H1 levels, consistent with a potential association between IGF-1 and MG-derived glycative stress in PCa progression. Moreover, IGF-1 stimulation of LNCaP cells increased MG-H1 accumulation, proliferation, colony formation, invasiveness, and gene expression of matrix metalloproteinase (MMP)-1, MMP-7, MMP-9, receptor for advanced glycation end-products (RAGE), and Osteopontin (OPN), all of which were markedly attenuated by the MG scavenger aminoguanidine (AG). Collectively, these findings support a potential contribution of MG-derived glycative stress to IGF-1-driven PCa progression. - Source: PubMed
Publication date: 2026/08/08
Manfredelli DomingaTorcoli CamillaLilli CinziaBellucci CatiaTalesa Vincenzo NMancuso FrancescaBaroni TizianoAntognelli Cinzia - Characterized by the progressive deterioration of periodontal supporting tissues, periodontitis (PD) is a prevalent oral disorder primarily instigated by dental plaque biofilms. Matrix stiffness (MS), a key extracellular matrix (ECM) property, regulates inflammatory cell function and tissue repair balance. Herein, we sought to screen for potential biomarkers linking MS to PD pathogenesis and characterize the molecular mechanisms governing their regulation. - Source: PubMed
Peng YanhuiYang XiaoqinFang WeiZhang LifangGuo TingZheng Hongyu - The Epidermal Growth Factor Receptor (EGFR) plays a pivotal role in 20-60% of cancer cases, including glioblastoma, lung adenocarcinoma, and head and neck squamous cell carcinoma, as reported in The Cancer Genome Atlas (TCGA) dataset. The present study employed an integrated in silico and experimental workflow to evaluate EGFR-targeted compounds from Terminalia arjuna. Drug-likeness and ADMET screening were performed, followed by molecular docking and 1000 ns molecular dynamics simulations. In vitro validation was conducted using cancer cell-based assays and network pharmacology to explore the molecular mechanisms associated with the identified compound. Screening shortlisted eight compounds from T. arjuna. Molecular docking identified Arjunaside C (-8.2 kcal/mol), Arjunapthanoloside (-7.7 kcal/mol), and Beta-sitosterol (-7.4 kcal/mol) as potential EGFR inhibitors compared to Erlotinib (-6.6 kcal/mol). Arjunapthanoloside formed more H-bonds and exhibited most stable interactions with EGFR. MD simulations at 1000 ns revealed lower RMSD, RMSF, SASA, and Rg values for the Arjunapthanoloside-EGFR complex, indicating enhanced stability. Direct binding validation was limited by the unavailability of purified Arjunapthanoloside; therefore, Arjuna extract was evaluated, which demonstrated potent cytotoxicity with an IC₅₀ of 9 µg/mL in H357 oral cancer cells. Flow cytometry confirmed apoptosis-mediated cell death by increased early- and late-apoptotic cell populations. Network pharmacology analysis further identified additional targets (MMP3, MMP7, MMP9, and HRAS) that are directly involved in various cancers. Overall, the findings provide new insights into the therapeutic potential of Arjunapthanoloside as a stable compound that interacts with EGFR from T. arjuna, highlighting its significance in EGFR-targeted anticancer research. - Source: PubMed
Publication date: 2026/08/18
Chahal ShiwaniDebnath AbhijitJain HeenaSingh Rajesh KumarBiswal SrutiMallick BibekanandMishra AkhileshSiwach Priyanka - Periodontitis has been linked to several respiratory diseases such as chronic obstructive pulmonary disease, asthma, and lung cancer; however, the role of periodontal health status and matrix metalloproteinases (MMPs) in interstitial lung diseases (ILDs) remains largely unexplored. The present study aimed to investigate periodontal health and evaluate serum and salivary levels of MMP-7, MMP-8, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with ILDs. A total of 75 individuals were included and divided equally into three groups: healthy controls, patients with chronic periodontitis, and patients with ILDs. Demographic factors such as age, gender, and socioeconomic status were recorded, along with clinical parameters including plaque index, gingival index, probing pocket depth, and clinical attachment level. The findings revealed that levels of MMP-7 and MMP-8 were significantly elevated in both the periodontitis and ILD groups compared to healthy controls, while TIMP-1 did not show notable variation among groups. Clinical periodontal parameters were also higher in patients with ILDs as well as those with chronic periodontitis. These results suggest a possible link between ILD and chronic periodontitis, both from clinical and biochemical perspectives. The study provides pioneering evidence in the emerging field of oral-systemic research, emphasizing the need for further investigations with larger sample sizes and interventional designs to strengthen the evidence base and explore possible genetic associations underlying this relationship. - Source: PubMed
Publication date: 2026/07/31
Hirkane Prerna SVerma Umesh PratapVerma Ajay KumarRastogi PavitraShrivastava AshutoshPathak Anjani Kumar - Acute kidney injury (AKI) is a common clinical syndrome associated with high morbidity and progression to chronic kidney disease. Ischaemia is a leading cause of AKI, driving cellular stress, metabolic reprogramming, and injury-associated epithelial states. Scalable human models that enable controlled investigation of ischaemic injury, repair, and therapeutic targets in AKI remain limited. We therefore assessed the extent to which induced pluripotent stem cell (iPSC)-derived human kidney organoids recapitulate key features of ischaemic AKI. - Source: PubMed
Publication date: 2026/08/19
Nunez-Nescolarde Ana BLiao YangPerlaza-Jiménez LauraPiran MehranCheng ZhengqiBarlow Chris KSteele Joel RDeveson DeannaMoreau Julie L MLee Han-ChungLi JinhuaSchittenhelm Ralf BWells Christine AShi WeiNikolic-Paterson David JCombes Alexander N