TAF7 monoclonal antibody (M01), clone 2C5
- Known as:
- TAF7 mab (anti-) (M01), clonality 2C5
- Catalog number:
- H00006879-M01
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- TAF7 monoclonal antibody (M01) clone 2C5
Related genes to: TAF7 monoclonal antibody (M01), clone 2C5
- Gene:
- GTF2H2B NIH gene
- Name:
- general transcription factor IIH subunit 2B (pseudogene)
- Previous symbol:
- -
- Synonyms:
- DKFZP686M0199
- Chromosome:
- 5q13.2
- Locus Type:
- pseudogene
- Date approved:
- 2008-07-04
- Date modifiied:
- 2015-11-09
- Gene:
- POLR1A NIH gene
- Name:
- RNA polymerase I subunit A
- Previous symbol:
- -
- Synonyms:
- DKFZP586M0122, FLJ21915, RPO1-4, RPA1
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-04-01
- Date modifiied:
- 2017-06-28
- Gene:
- TAF7 NIH gene
- Name:
- TATA-box binding protein associated factor 7
- Previous symbol:
- TAF2F
- Synonyms:
- TAFII55
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-07
- Date modifiied:
- 2016-10-05
- Gene:
- TDRP NIH gene
- Name:
- testis development related protein
- Previous symbol:
- C8orf42
- Synonyms:
- INM01, TDRP1, TDRP2
- Chromosome:
- 8p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-28
- Date modifiied:
- 2015-08-26
Related products to: TAF7 monoclonal antibody (M01), clone 2C5
Related articles to: TAF7 monoclonal antibody (M01), clone 2C5
- Achieving an optimal balance among key optical performance parameters (i.e., bandgap, second-harmonic generation (SHG), and birefringence) is critically important for addressing application constraints and advancing the development of nonlinear optical (NLO) materials. We report herein the first examples of deep-ultraviolet (deep-UV) transparent mixed d-metal oxyfluorides A(NbOF)(TaF) (ANTOF: A = K, Rb, Cs, NH), synthesized through a synergistic dual-site strategy. Our synthetic strategy enables the targeted incorporation of highly distorted d-metal octahedra into metal fluorides, creating two distinct d-metal polyhedra with complementary microstructural features that can reconcile trade-offs in key optical properties. By introducing 4d-Nb-based [NbOF] oxyfluoride octahedra into the centrosymmetric parent 5d-Ta-based fluorides ATaF, the resultant ANTOFs not only crystallize with noncentrosymmetric polar structures but, more importantly, demonstrate exceptional performance, including record-high phase-matchable SHG responses for deep-UV transparent d-metal oxyfluorides (3.3-3.8 × KHPO @ 1064 nm (visible region) and 0.33-0.38 × β-BaBO @ 532 nm (UV region)), wide bandgaps (> 6.36 eV), and suitable birefringence (Δn = 0.093-0.105 @ 546 nm). Theoretical calculations and crystal structure analyses reveal that the superior linear and nonlinear optical properties of the ANTOFs originate from the dual-site synergy between the polarizable [NbOF] octahedra and the [TaF] pentagonal bipyramids, in which ligand-to-metal charge transfer transitions are suppressed. - Source: PubMed
Publication date: 2025/09/16
Zhang XiaotianJiang XingxingGao HuiDuanmu KainingWu ChaoLin ZheshuaiHuang ZhipengHumphrey Mark GZhang Chi - The whiteleg shrimp (Penaeus vannamei) is one of the most economically important aquaculture species worldwide. Transcription initiation factor TFIID subunit 7 (TAF7), a core component of the TFIID complex, is known to regulate transcription through interactions with other transcription factors. However, its role in crustacean immunity remains largely unexplored. In this study, we cloned and functionally characterized a TAF7 homolog from P. vannamei, designated as PvTAF7. The gene comprises an open reading frame (ORF) of 1110 bp, encoding a 369-amino-acid protein containing a conserved TAFⅡ55 domain. Phylogenetic analysis clustered PvTAF7 within the Decapoda clade, indicating strong evolutionary conservation among crustaceans. Tissue distribution analysis showed that PvTAF7 is highly expressed in the hepatopancreas and hemocytes, key immune tissues in shrimp. PvTAF7 expression was significantly upregulated in response to Vibrio parahaemolyticus (including the AHPND strain) in both hemocytes and hepatopancreas. RNA interference-mediated knockdown of PvTAF7 led to reduced expression of immune-related genes, including lysozyme, crustins, hemocyanins, and the transcription factor PvYY1, and resulted in increased mortality following Vibrio infection. Moreover, GST pull-down assays and structural modeling demonstrated that PvTAF7 interacts with PvYY1 via its TAFⅡ55 domain and the zinc finger domain of PvYY1, forming a functional protein complex. Collectively, these findings reveal that PvTAF7 plays a critical role in the antibacterial immune response of P. vannamei, likely by regulating immune gene expression through its interaction with PvYY1. - Source: PubMed
Publication date: 2025/07/30
Yang PeikuiWang ShuqinChen TongyingZhao QiongjunYe XuelianZeng BoxiZou XianghuiZheng YuzhongWang Ruixuan - Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with a poor prognosis. Identifying reliable prognostic biomarkers and therapeutic targets is crucial for improving patient outcomes. This study aimed to systematically identify proliferation-essential genes (PEGs) associated with HNSCC prognosis using CRISPR-Cas9 screening data. - Source: PubMed
Publication date: 2025/04/22
Pang Ke-LingLi PianYao Xiang-RongXiao Wen-TaoRen XingHe Jun-Yan - Identification of metastasis drivers of triple-negative breast cancer (TNBC) is a multifaceted challenge. Here, we identified TATA-box binding protein associated factor 7 (TAF7) as a candidate to modulate TNBC metastasis. TAF7 exhibited high expression in metastatic TNBC patients, and its elevated expression showed a negative correlation with overall survival in TNBC patients. The knockdown of TAF7 suppressed the migration and invasion of TNBC, suggesting TAF7 plays a role in the metastatic processes. Further, TAF7 was enhancing serum amyloid A1 (SAA1) transcription by binding to a specific motif in the SAA1 gene promoter. The elevated SAA1 in TNBC cells directly increased E-cadherin and N-cadherin phosphorylation thereby regulating cell adhesion. Mechanistically, TAF7 modulated cell invasion, migration, and lung metastasis through an SAA1-dependent manner and experiments. Taken together, it is likely that TAF7 could directly act on the SAA1 gene promoter, upregulating SAA1 and consequently promoting TNBC metastasis. - Source: PubMed
Publication date: 2025/02/10
Zhang WanjunWang JunLi HanningZhang XueYao DunjieZhang HuiminZhou XinhongNie JiaqiLai TongxingZhu HaichuanGong YipingTanaka YoshimasaLi XingruiLiao XinghuaSu Li - Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy often diagnosed in advanced stages. Despite advancements in therapy, it retains a high mortality rate and significant recurrence risk. This study utilizes single-cell sequencing (scRNA-seq) to unravel HNSCC's complexity, identify therapeutic targets, and refine prognostic models. - Source: PubMed
Publication date: 2025/03/10
Chai YuanhaoZhang JianlinShao WenwenZhang Ziwei