KIR2DL1 antibody
- Known as:
- KIR2DL1 (anti-)
- Catalog number:
- orb48427
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- KIR2DL1 antibody
Related genes to: KIR2DL1 antibody
- Gene:
- KIR2DL1 NIH gene
- Name:
- killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
- Previous symbol:
- -
- Synonyms:
- cl-42, nkat1, 47.11, p58.1, CD158A
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-14
- Date modifiied:
- 2016-11-09
Related products to: KIR2DL1 antibody
Related articles to: KIR2DL1 antibody
- The killer-cell immunoglobulin-like receptors (KIR) are a family of activating and inhibitory Class I human leukocyte antigen (HLA-I) binding receptors expressed on natural killer (NK) cells and subsets of T cells. The KIR detect HLA-I molecules in a peptide-dependent manner, with some KIR displaying exquisite peptide specificity. Studying peptide recognition by KIR often uses TAP-deficient cell lines expressing single HLA-I alleles, which are heterogenous and time consuming to generate. Here, we established an alternative approach using peptide-exchange technologies hitherto developed for studying T cell recognition of HLA-I. - Source: PubMed
Publication date: 2026/05/25
Murali Tanusya MLi BeiningHoos EmeryCollinson LucyLong Eric ODushek OmerElliott TimSim Malcolm J W - Immune dysregulation and cognitive deficits are increasingly recognized in adolescent major depressive disorder (MDD), yet their interrelationship remains unclear. This study aimed to investigate peripheral immune-inflammatory alterations and natural killer (NK) cell phenotypes, and explore their association with cognitive function in adolescent MDD. - Source: PubMed
Publication date: 2026/05/16
Wang JiahuiHou LingzhiLi CaiLiu YitongXu YanHe YangYang LeiWang LiLiu QidongCheng JunZhang YanyanMa YunmiaoXu HaiweiLi Hong - The Novel KIR3DL1*0010123, KIR3DL1*0010124, KIR2DL1*0010108, KIR2DL1*0010109 alleles were identified in healthy individuals from the Indian Population. - Source: PubMed
Sharma GauravAgarwal DishaKhadwal AlkaDas ReenaMalhotra Pankaj - The killer-cell immunoglobulin-like receptor () gene cluster exhibits complicated diversity in haplotype content, copy-number variation (CNV), and allelic polymorphism. To date, 2,286 distinct alleles have been released in the IPD-KIR Database. However, little is known about the impact of high-resolution-level allelic polymorphisms on leukemia. Our previous study showed that the genotype carrying more inhibitory genes conferred differential protection against leukemia in the Chinese Southern Han population. Herein, we hypothesized the impact of alleles in the haplotype and cognate human leukocyte antigen (HLA) ligand on leukemia. - Source: PubMed
Publication date: 2026/02/05
Deng ZhihuiZhen JianxinLi YunanLiang ShuangZhang ManruCai SiqiJiang RenhuiYang ZhichaoYu QiongWang JinyongLiu Jie - Broadly neutralizing antibodies (bnAbs) are evaluated as possible alternatives to standard antiretroviral treatment (ART) for maintaining control of HIV-1 replication and may enhance immune responses to reduce or control the viral reservoir. However, the immunological and virological effects of bnAbs in infants and children are unknown. We conducted a detailed analysis of proviral reservoir dynamics and antiviral immune responses in a unique group of young children from Botswana who started ART at birth and then stopped standard ART while receiving the bnAbs 10-1074 and VRC01-LS in a subsequent clinical trial. No quantitative changes in frequencies of proviral sequences were observed during bnAb treatment, but selection of genome-intact proviruses in transcriptionally repressive heterochromatin regions occurred in some study participants. Faster viral rebound following standard ART cessation was linked to elevated proportions of KIR2DL1-positive NK cells. In contrast, delayed viral rebound and more limited viral reservoir size were associated with elevated proportions of NKG2A-positive NK cells and with the HLA-B-21M signal peptide polymorphism. HIV-specific T cell responses were low in all study participants and unrelated to viral reservoir sizes or clinical outcomes following ART interruption. These results suggest that, in young children, specific NK cell subsets and KIR-HLA interactions might be linked to HIV-1 rebound kinetics after substitution of standard ART with bnAbs. - Source: PubMed
Publication date: 2026/02/16
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