CHRNA2 antibody (RBITC)
- Known as:
- CHRNA2 (anti-) (RBITC)
- Catalog number:
- orb131187
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CHRNA2 antibody (RBITC)
Related genes to: CHRNA2 antibody (RBITC)
- Gene:
- CHRNA2 NIH gene
- Name:
- cholinergic receptor nicotinic alpha 2 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-11
- Date modifiied:
- 2016-10-05
Related products to: CHRNA2 antibody (RBITC)
Related articles to: CHRNA2 antibody (RBITC)
- Beige-adipocyte activity, mediated by CHRNA2, significantly influences adipose function and systemic metabolism. The CHRNB2 subunit forms a functional receptor with CHRNA2 and is essential for the response to nicotinic acetylcholine receptor agonists in beige adipocytes. Deletion of Chrnb2 in mice compromises the adaptive response to cold in subcutaneous adipose tissue and renders exacerbated metabolic dysfunction due to diet-induced obesity. This cholinergic signaling within subcutaneous adipose tissue declines with aging. CHRNB2 partial agonists, a family of drugs clinically used for smoking cessation, activate both murine and human beige adipocytes. - Source: PubMed
Publication date: 2026/05/13
Liu ShanshanZhu KezhouZhang WenwenPan TongO'Brien MartinAbe IchitaroDale LilyPiejak JustinHoussein NadiaZhang BiyangFein MatthewKajimura ShingoYung RaymondXu X Z ShawnWu Jun - In CA1 pyramidal neurons (CA1-PYRs), plateau potentials control synaptic plasticity and the emergence of place cell identity. Here, we show that dendritic inhibition terminates plateaus in an all-or-none manner in CA1-PYRs recorded in acute hippocampal slices from mice of either sex. Plateaus were initially resistant to inhibition but became increasingly susceptible to termination as they progressed. Two subtypes of dendrite-targeting oriens-lacunosum moleculare (OLM) interneurons, accessed in transgenic mice based on the expression of the genes or (OLM and OLM, respectively), could terminate plateau potentials. OLM generated slower postsynaptic currents that terminated plateaus more effectively than OLM Voltage-gated Ca channels (VGCCs) were necessary for plateaus, which were prolonged by blocking small-conductance Ca-activated K channels (SK). A single-compartment model with these two conductances recapitulated core experimental findings and provided a mechanistic explanation for terminations. Plateaus arose from VGCCs maintained in the active state by sustained Ca influx, a positive feedback loop that was quasi-balanced by I Inhibition terminated plateaus by driving the membrane potential below a dynamic threshold to deactivate VGCCs and end the positive feedback loop. Similar all-or-none termination dynamics were observed for plateaus evoked under cholinergic modulation. Lastly, two-photon Ca imaging showed that plateaus evoke large dendritic Ca transients that were graded by terminations. Overall, our results demonstrate how the feedback inhibitory circuit interacts with intrinsic cellular mechanisms to regulate plateau potentials and shape dendritic Ca signals in CA1-PYRs. - Source: PubMed
Publication date: 2026/05/20
Vaasjo Lee OKotermanski Shawn EPatel TiyaShi Hengyue JMachold RobertChamberland Simon - Prostate cancer (PRAD/PCa) is a leading malignancy in men, with high incidence and mortality rates globally. Although treatments like androgen deprivation therapy (ADT) and chemotherapy have advanced, the prognosis for advanced or metastatic PCa remains unfavorable. Post-translational modifications (PTMs), particularly protein palmitoylation, have emerged as critical regulators of cancer progression and potential therapeutic targets. This study investigates the features of palmitoylation-related genes (PRGs) in PRAD, their links to immune infiltration, and potential therapeutic applications. - Source: PubMed
Publication date: 2026/01/26
Wang MingchaoDing YimingGao Lei - Psychoactive substance use (PSU) and cancer are frequently observed comorbidities that have reciprocal influences and shared behavioral traits of the affected patients. While, e.g., nicotine and alcohol are major carcinogens in the etiology of lung and head and neck cancers, little is known about a shared overarching genetic architecture of PSU and cancer that may predispose individuals to both illnesses. - Source: PubMed
Publication date: 2026/02/05
Song JiahangLi PengzhuCanis MartinUnger KristianHaas Nikolaus AlexanderGires Olivier - Pneumonia risk is influenced by demographics, chronic disease burden, lifestyle, and environmental factors. Despite previous genetic studies, the impact of host genetics on pneumonia, particularly within specific patient groups, remains unclear. - Source: PubMed
Publication date: 2026/01/23
Heikkilä AnniSliz EevaVäyrynen SaraReis KadriElnahas Abdelrahman GReigo AnuEsko Tõnu Kettunen JohannesHautala Timo