LAMP3 antibody
- Known as:
- LAMP3 (anti-)
- Catalog number:
- orb96058
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- LAMP3 antibody
Related genes to: LAMP3 antibody
- Gene:
- LAMP3 NIH gene
- Name:
- lysosomal associated membrane protein 3
- Previous symbol:
- -
- Synonyms:
- LAMP, TSC403, DC-LAMP, DCLAMP, CD208
- Chromosome:
- 3q27.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-29
- Date modifiied:
- 2016-10-05
Related products to: LAMP3 antibody
Related articles to: LAMP3 antibody
- Understanding alterations in immune homeostasis can help early diagnosis and prevention in rheumatoid arthritis (RA). As joint pain often precedes RA onset, we analysed pain-associated immune mediators in individuals at risk of RA (RISK-RA) and in early untreated RA. Serum CCL22 levels were elevated in both groups, prompting us to further study its sources and effects in RA. - Source: PubMed
Publication date: 2026/09/16
Filipović MašaAfonso MarceloArgyriou AlexandraCîrciumaru AlexandraJoshua VijayRingh MikaelGrönwall CarolineCarlberg KonstantinChen Szu-YingDehara MarinaKrishnamurthy AkilanVivar NancyVan Hulle SenneDecruy TineWähämaa HeidiEkström Tomas JWadsworth Marc HSharma Ravi KumarPadyukov LeonidElewaut DirkVenken KoenAskling JohanWinkler AaronSmith Julia EKlareskog LarsCatrina Anca IHensvold AaseMalmström VivianneChemin KarineRéthi Bence - The immune system has emerged as a critical factor influencing neurodevelopment in offspring. While this is increasingly well-studied in the context of maternal immune activation (MIA), the relationship between postnatal immune activation and brain development in childhood is far less studied. In the current study, we performed targeted immune proteomics to analyse 356 inflammation-associated proteins and examine whether peripheral immune physiology is associated with multimodal neuroimaging metrics, brain growth centiles, and cortical microstructure, in 5-year-old children. We included 101 typically developing children with immune proteomics and multimodal neuroimaging data covering structural and diffusion-weighted magnetic resonance imaging (MRI) that was modelled with FSL's linked independent component analysis (FLICA) to yield 10 multimodal brain components. For a subset of the analyses utilising immune proteomics and structural brain growth centile data, the sample size was 126 children. We observed consistent negative associations between serum immune proteins and both grey matter volume growth and global cortical thickness; for the latter, associations were statistically significant after false discovery rate correction for CXCL10, IL17A, and LILRB4. Similarly, many immune proteins were associated with increased mean diffusivity across the cortex, most notably LAMP3, NCR1, SIGLEC1, FASLG, and CXCL10 in the right medial orbitofrontal cortex. Collectively, these findings provide the first characterisation of the relationship between immune physiology and brain structure in children, and demonstrate notable associations with global cerebrocortical development. This should be extended by future studies with larger samples and multiple sampling. - Source: PubMed
Publication date: 2026/09/10
Barron AaronRosberg AylinTuulari Jetro JLukkarinen MinnaMerisaari HarriSilver EeroKumpulainen VenlaCopeland AnniSaukko EkaterinaDickens Alex MOresic MatejHyötylainen TuuliaKarlsson LinneaKarlsson HasseWigley Isabella L C MarianiPulli Elmo P - Macrophages, T lymphocytes and NK cells are central to inflammatory responses in localized scleroderma (LS morphea), but their inflammatory signature and differentiation remain inadequately classified. This study examined the transcriptomes of these cell types to clarify their contribution to LS pathogenesis. Single-cell RNA sequencing was performed on LS skin. Ligand-receptor interaction and spatial transcriptomics confirmed the location of the altered immune phenotypes. Seventeen main cell types were identified, with focus on T cells, NK cells macrophages and dendritic cells (DCs). While LS and healthy samples show similar proportions of T and NK subpopulations, T follicular helper-like cells were more prevalent in LS. Myeloid populations showed more distinct stratification. TREM2+ and FCN1+ macrophages, and LAMP3+ DCs were expanded in LS, displaying an interferon signature consistent with an inflammatory phenotype. Ligand-receptor analysis demonstrated increased signaling interactions between T/NK cells and myeloid cells in LS, with pathways such as CXCL, CCL, TNF, and INF-II playing important roles. This scRNAseq study identifies expanded FCN1+ and TREM2+ macrophages and T follicular helper-like cells in untreated LS skin, highlighting immune dysregulation and offering insights into potential therapeutic targets. - Source: PubMed
Publication date: 2026/09/09
Mirizio EmilyWerner GiffinHutchins TheresaSanyal AnweshaEsencan DerenTabib TracyChen WeiLafyatis RobertJacobe HeidiTorok Kathryn S - Familial Parkinson's disease (PD) and vascular parkinsonism (VP) present overlapping features and may co-exist. To investigate whether PD and VP may share a potential pathogenic link and to what extent white matter hyperintensities may influence PD phenotype, we used the modified Scheltens scale and presented a descriptive and exploratory analysis of the classic neuroradiological features of cerebral small vessel disease (cSVD) in the axial T2-FLAIR MRI sequences in a cohort of 104 familial PD and PD prodromal patients and 48 age-matched controls from the PPMI publicly available database. We next performed whole exome sequencing to examine the protein coding variability in the main PD-causing and risk genes (VPS35, DJ1, PINK1, ATP13A2, PRKN, SNCA, LRRK2, GBA, MAPT, LAMP3, STK39) in a cohort of 96 patients with familial cSVD and 243 elderly healthy individuals (HEX database). In this cohort, patients with familial and prodromal PD present a moderate burden of superficial frontal white matter hyperintensities (p-value = 3.46e-06, Bonferroni-corrected), linked to a mild reduction of motor and cognitive function and an increased LRRK2 p.G2019S and p.R1441C variant penetrance, and bilateral basal ganglia periventricular enlarged spaces (p-value = 2.64e-03, Bonferroni-corrected). Moreover, one-third of familial PD patients displayed a burden of lacunar thalamic strokes (p-value = 0.058), associated with a moderate hypokinetic-rigid syndrome. Finally, we report no known pathogenic coding variant in the main PD causative genes and risk factors in a cohort of 96 early-onset cSVD Caucasian patients. Our study adds to the understanding of potential cSVD hallmarks within this familial LRRK2, GBA and SNCA PD-PD prodromal cohort. - Source: PubMed
Publication date: 2026/09/08
Mahat BigyanMalla BimalaFoddis MarcoBeule DieterBras JoseGuerreiro RitaKola VasilisSchmitt Hans-MichaelEndres MatthiasSassi Celeste - Tertiary lymphoid structures (TLS) are spatially organized immune niches associated with therapeutic response and favorable outcomes in breast cancer (BC). However, TLS assessment currently relies on invasive tissue-based analyses, and the biological mechanisms underlying imaging-based TLS prediction remain poorly understood. - Source: PubMed
Publication date: 2026/09/03
Yu YushuaiWang QingLin YidanHuang KaiyanWang RuijuanWang JunxiaoHuang XieweiZhang JieChen WeiweiChen RuiliangChen XuejunMeng FanZhang HengyuYuan JunhuiLin JianqingSong Chuangui