HMGCLL1 antibody
- Known as:
- HMGCLL1 (anti-)
- Catalog number:
- orb77703
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- HMGCLL1 antibody
Related genes to: HMGCLL1 antibody
- Gene:
- HMGCLL1 NIH gene
- Name:
- 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1
- Previous symbol:
- -
- Synonyms:
- DKFZP434G1411, bA418P12.1
- Chromosome:
- 6p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-20
- Date modifiied:
- 2018-11-16
Related products to: HMGCLL1 antibody
Related articles to: HMGCLL1 antibody
- - Source: PubMed
Publication date: 2026/03/30
Perusini Maria AgustinaPagnano KatiaPavlovsky CarolinaŽáčková DanielaMayer JiříMoiraghi BeatrizVarela Ana InesBianchini MichelePascoal Lopes Ana BeatrizDuarte Gislainede Souza Carmino AntonioJežíšková IvanaKvetková AnežkaJurček TomášWon Lee HyeChang Myung HeeMedeiros Jessie J FAbelson SagiKim Dennis Dong Hwan - Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by aberrant fibroblast activation and excessive extracellular matrix (ECM) accumulation, resulting in irreversible lung remodeling. Although fibroblasts are central to IPF pathogenesis, comprehensive transcriptomic analyses of IPF patient-derived lung fibroblasts remain limited. This study aimed to identify novel molecular contributors to IPF through transcriptomic profiling of lung fibroblasts. - Source: PubMed
Publication date: 2026/03/27
Seo Eun-JeongLee Jong-UkPark Seung-LeeKim Min-KyungChoi Jae-SungHwang Hun-GyuKim Jung-HyunChang Hun-SooPark Choon-Sik - Reproductive traits are critical for improving productivity and profitability in the pig industry, and genome-wide association studies (GWASs) are a powerful tool in detecting genetic markers related to target traits. Genome imputation provides an effective approach to obtain a greater number of genetic markers from low-density sequencing data. China's pig industry recently introduced an imputation panel and is now seeking to determine what types of data are required to meet breeding needs. In this study, we collected and analyzed two pig sequencing datasets, including Yorkshire pig (YY), Landrace pig (LL), and Duroc pig (DD), genotyped by either an SNP chip ( = 816) or genotyping-by-targeted sequencing ( = 314), and applied an imputation strategy before validation in a third dataset ( = 2401). The aim of this study was to identify SNPs associated with reproductive traits and compare imputation results of two different types of data to evaluate whether sample size or marker density more strongly impacts imputation-enabled GWAS performance. Through a GWAS, we identified 73 significant SNPs from imputed Chip data across seven reproductive traits, 94 SNPs from imputed GBTS data across three traits, and 34 SNPs from the combined dataset across seven traits. Seven of these SNPs passed validation and were associated with number born alive, number born healthy, and gestation length. Gestation length (GL) and number born alive (NBA) are the most noteworthy traits. and are high-confidence candidate genes affecting GL and NBA, respectively. In addition to , , , , , , , , , , , , and are associated with GL. Moreover, in addition to , , , , and are associated with NBA. The results of this study indicate that sample size is of greater importance than marker density in imputation strategies and provide beneficial insights into genes affecting pigs' reproductive traits. - Source: PubMed
Publication date: 2026/02/12
Zhou JiekeFu YangZhang YingyingTu WeilongHuang JiLiang YaxuLi BusheZhang HejunLiu YanWang KejunWang HongyangTan Yongsong - Large porcine F crosses are a valuable resource for discovering QTL and genetic variants for relevant traits. Past studies have been largely limited to SNPs and short insertions and deletions. Structural variants (SVs) are becoming a major area of interest in this respect. Here we present results from a genome-wide association study with SVs imputed from medium-density SNP array to the whole genome sequence level that were used to investigate the genetic relationship between important production traits and metabolic enzyme activity in an F cross based on the breeds Meishan, Piétrain, and European wild boar. Genetic and phenotypic correlations between the two trait classes were high. We were able to pinpoint common genetic loci to a QTL on SSC7, encompassing numerous large intron deletions in the PRIM2 gene as well as in HMGCLL1, BMP5, TRERF1, COL21A1, LRRC1, and UBR2. The most pronounced genetic associations were observed for the content of NADP-malate dehydrogenase in the tissue. Hence, we propose that the content and activity of malate dehydrogenase is directly connected to important pig production traits, and we present a comprehensive list of large intronic deletions as promising candidates for causality. The variants were validated in independent pig populations, where the majority of the discovered SVs were present, indicating that they are not only relevant to the breeds investigated here. - Source: PubMed
Falker-Gieske ClemensBlaj IuliaKrizanac Ana-MarijaKilic IsabelReich PaulaBennewitz JörnTetens Jens - Lack of clinically specific biomarkers has impeded the precise diagnosis of schizophrenia, meanwhile, limited comprehending of pathogenesis for schizophrenia has restricted the effective treatment. - Source: PubMed
Publication date: 2021/12/01
Wang TianyangLi PingMeng XiangyuZhang JinlingLiu QiJia CuicuiMeng NanaZhu KunjieLv DanSun LeiShang TinghuiziLin YanNiu WeipanLin Song