AFF2 antibody
- Known as:
- AFF2 (anti-)
- Catalog number:
- orb77515
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- AFF2 antibody
Related genes to: AFF2 antibody
- Gene:
- AFF2 NIH gene
- Name:
- AF4/FMR2 family member 2
- Previous symbol:
- FMR2
- Synonyms:
- FRAXE
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-27
- Date modifiied:
- 2019-03-26
Related products to: AFF2 antibody
Related articles to: AFF2 antibody
- DEK::AFF2 fusion‑positive sinonasal tract and skull base nonkeratinizing squamous cell carcinoma (DEK::AFF2 SCC) is a rare and recently recognized entity; however, its clinicopathologic and demographic features remain incompletely defined. We aimed to further refine and supplement the characterization of this entity. We retrieved institutional pathology records and identified 50 DEK::AFF2 SCCs at a single institution (2009-2025). The cohort included 20 males and 30 females aged 18-74 years (median, 50.5 y). The most common presenting symptoms were nasal obstruction and epistaxis. The predominant primary site was the paranasal sinus, followed by the nasal cavity and nasopharynx. Histologically, most tumors exhibit mixed exophytic and endophytic growth patterns, complex anastomosing trabeculae, monotonous cytomorphology, acantholytic changes, and tumor-infiltrating neutrophils. High-grade histologic features and infiltration were observed in 24% of the cases; 6% presented features resembling mucoepidermoid carcinoma, and 4% presented an ameloblastoma-like appearance. Immunohistochemically, more than 70% of the cases coexpressed squamous and glandular markers. The recurrence rate was 59.2%, the lymph node metastasis rate was 24.5%, the distant metastasis rate was 20.4%, and the disease‑related mortality rate was 24.5%, with a median follow-up period of 71 months (range, 5-235 mo). This study expanded the histologic spectrum of DEK::AFF2 SCC and demonstrated its aggressive behavior, highlighting the need for accurate differentiation from mimics and long‑term surveillance. - Source: PubMed
Publication date: 2026/07/31
Zhai ChangwenLiu HongqinZhang JiahaoWang ShuyiLin Lan - The World Health Organization (WHO) recently published the 5th edition of head and neck tumors. This edition describes both existing entities and a group of emerging entities, along with updates regarding taxonomy and detailed characteristics of tumors and tumor-like lesions. Sinonasal tumors and skull base tumors represent a heterogeneous group of tumors with significant histological variability and overlap in imaging methods. An important change in the 5th edition of the WHO classification is the relocation of recurrent soft tissue, hematolymphoid, and neuroectodermal tumors into a separate chapter, meaning they are no longer repeated in other chapters as they were previously. Only those tumors that are unique to the sinonasal area remain classified in this chapter. In this review article, we will primarily provide a brief overview of all 24 diagnostic entities, allowing readers to gain a concise understanding. We will focus in detail on the new entities of SWItch/Sucrose Non-Fermentable complex-deficient sinonasal carcinomas and human papillomavirus-related multiphenotypic sinonasal carcinoma. In another review article in this issue, we detailed IDH-mutated sinonasal malignancies; therefore, we will exclude them from this overview and concentrate on DEK::AFF2 carcinomas, currently classified as sinonasal undifferentiated carcinomas or non-keratinizing squamous cell carcinomas, respectively. - Source: PubMed
Bradová MartinaLaco JanSkálová Alena - Is exome sequencing (ES) an efficient approach for simultaneous analysis of causative single gene defects and copy number variants (CNV) in unexplained premature ovarian insufficiency (POI)? - Source: PubMed
Publication date: 2026/06/17
Valkna AnuKikas TriinJakovlev ÜlleMõttus OliverDutta AvirupErlang KülliPunab MargusRull KristiinaLaan Maris - DEK::AFF2 fusion-associated nonkeratinizing squamous cell carcinoma is a recently recognized HPV-independent entity characterized by deceptively bland morphology and potential mimicry of benign or inflammatory lesions. - Source: PubMed
Publication date: 2026/06/19
Li YanMa LinxiangYang WenlinZhang RenyaWang Ting - Sinonasal squamous cell carcinoma (SNSCC) is a rare malignancy with variable outcomes, and the prognostic impact of molecular alterations remains incompletely defined. This meta-analysis aims to clarify the associations of genetic alterations and protein expression with clinical outcomes in SNSCC. - Source: PubMed
Publication date: 2026/06/01
Vasudevan Srivatsa SuryaCradeur AmberPolson MadelineNathan Cherie-Ann OAhmed Omar GYim Michael T