AFF2 antibody
- Known as:
- AFF2 (anti-)
- Catalog number:
- orb77515
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- AFF2 antibody
Related genes to: AFF2 antibody
- Gene:
- AFF2 NIH gene
- Name:
- AF4/FMR2 family member 2
- Previous symbol:
- FMR2
- Synonyms:
- FRAXE
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-27
- Date modifiied:
- 2019-03-26
Related products to: AFF2 antibody
Related articles to: AFF2 antibody
- Copy number variations (CNVs) represent an important source of structural genomic variation contributing to genomic diversity in livestock species. The Nagami Mithun (Bos frontalis), a semi-domesticated bovid indigenous to the forested hill regions of Northeast India, remains poorly characterized at the level of genome structural variation. In this study, whole-genome resequencing data from 12 Nagami Mithun individuals were analyzed to establish the first genome-wide copy number variation (CNV) map for this indigenous population. After quality filtering and alignment to the Bos taurus ARS-UCD2.0 reference genome, CNVs were detected using the read-depth-based tool CNVnator v0.4.1 with stringent filtering criteria (e-value < 0.05, q0 < 0.5, length > 1 kb). A total of 7273 CNVs were identified, including 5005 deletions (68.8%) and 2,268 duplications (31.2%), which were subsequently integrated into 1135 CNV regions (CNVRs). Population-level integration of individual CNVs resulted in 1135 CNVRs spanning approximately 173.4 Mb of the autosomal genome. Functional annotations identified 2281 genes overlapping CNVRs. Gene Ontology enrichment analysis identified overrepresentation of genes annotated to chemosensory perception, immune-related processes, and amino-acid transport functions, while KEGG pathway analysis identified enrichment of pathways annotated as natural killer cell-mediated cytotoxicity and antigen processing and presentation. CNV-QTL overlap analysis identified hypothesis-generating candidate genomic regions harboring genes (e.g., AFF2, EDA, COL4A5, TRPC5) that are associated with production, reproduction, and conformation traits in bovines, representing putative positional overlaps requiring future validation in Mithun populations. This study provides a foundational structural variation resource for future comparative, conservation, and functional genomic studies in Mithun. These findings provide a valuable genomic resource for future marker-assisted selection, comparative genomics, and conservation breeding programs aimed at preserving Nagami Mithun populations. - Source: PubMed
Publication date: 2026/08/20
Kichu BendangkokbaKumar HarshitMondal RajkrishnaChotso KuluveChamuah J KHanah S SShivanagowda Girish Patil - DEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal neoplasm that closely mimics Schneiderian papilloma. Although one report has described fine-needle aspiration cytology of a metastatic lymph node, scrape cytological features from the primary site remain undocumented. - Source: PubMed
Publication date: 2026/08/17
Satomi HidetoshiHonma KeiichiroKukita YojiAshimura MinakoKoyanagi YukiKodama YoshinoriTanada Satoshi - DEK::AFF2 fusion‑positive sinonasal tract and skull base nonkeratinizing squamous cell carcinoma (DEK::AFF2 SCC) is a rare and recently recognized entity; however, its clinicopathologic and demographic features remain incompletely defined. We aimed to further refine and supplement the characterization of this entity. We retrieved institutional pathology records and identified 50 DEK::AFF2 SCCs at a single institution (2009-2025). The cohort included 20 males and 30 females aged 18-74 years (median, 50.5 y). The most common presenting symptoms were nasal obstruction and epistaxis. The predominant primary site was the paranasal sinus, followed by the nasal cavity and nasopharynx. Histologically, most tumors exhibit mixed exophytic and endophytic growth patterns, complex anastomosing trabeculae, monotonous cytomorphology, acantholytic changes, and tumor-infiltrating neutrophils. High-grade histologic features and infiltration were observed in 24% of the cases; 6% presented features resembling mucoepidermoid carcinoma, and 4% presented an ameloblastoma-like appearance. Immunohistochemically, more than 70% of the cases coexpressed squamous and glandular markers. The recurrence rate was 59.2%, the lymph node metastasis rate was 24.5%, the distant metastasis rate was 20.4%, and the disease‑related mortality rate was 24.5%, with a median follow-up period of 71 months (range, 5-235 mo). This study expanded the histologic spectrum of DEK::AFF2 SCC and demonstrated its aggressive behavior, highlighting the need for accurate differentiation from mimics and long‑term surveillance. - Source: PubMed
Publication date: 2026/07/31
Zhai ChangwenLiu HongqinZhang JiahaoWang ShuyiLin Lan - The World Health Organization (WHO) recently published the 5th edition of head and neck tumors. This edition describes both existing entities and a group of emerging entities, along with updates regarding taxonomy and detailed characteristics of tumors and tumor-like lesions. Sinonasal tumors and skull base tumors represent a heterogeneous group of tumors with significant histological variability and overlap in imaging methods. An important change in the 5th edition of the WHO classification is the relocation of recurrent soft tissue, hematolymphoid, and neuroectodermal tumors into a separate chapter, meaning they are no longer repeated in other chapters as they were previously. Only those tumors that are unique to the sinonasal area remain classified in this chapter. In this review article, we will primarily provide a brief overview of all 24 diagnostic entities, allowing readers to gain a concise understanding. We will focus in detail on the new entities of SWItch/Sucrose Non-Fermentable complex-deficient sinonasal carcinomas and human papillomavirus-related multiphenotypic sinonasal carcinoma. In another review article in this issue, we detailed IDH-mutated sinonasal malignancies; therefore, we will exclude them from this overview and concentrate on DEK::AFF2 carcinomas, currently classified as sinonasal undifferentiated carcinomas or non-keratinizing squamous cell carcinomas, respectively. - Source: PubMed
Bradová MartinaLaco JanSkálová Alena - Is exome sequencing (ES) an efficient approach for simultaneous analysis of causative single gene defects and copy number variants (CNV) in unexplained premature ovarian insufficiency (POI)? - Source: PubMed
Publication date: 2026/06/17
Valkna AnuKikas TriinJakovlev ÜlleMõttus OliverDutta AvirupErlang KülliPunab MargusRull KristiinaLaan Maris