CCDC146 antibody (FITC)
- Known as:
- CCDC146 (anti-) (fluorecein)
- Catalog number:
- orb5093
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CCDC146 antibody (FITC)
Related genes to: CCDC146 antibody (FITC)
- Gene:
- CCDC146 NIH gene
- Name:
- coiled-coil domain containing 146
- Previous symbol:
- -
- Synonyms:
- KIAA1505
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2007-12-06
- Date modifiied:
- 2014-12-03
Related products to: CCDC146 antibody (FITC)
Related articles to: CCDC146 antibody (FITC)
- - Source: PubMed
Publication date: 2026/03/23
Ruan TiechaoLin TingtingWang LingboYang YihongShen GanJiang ChuanWang XiangLiu MohanZhuo LiangchaiZhang YingtengTan YueqiuHuang GuoningMu DezhiShen Ying - Migraine is a common, disabling neurological disorder. Genome-wide association studies have mapped numerous migraine risk loci, but the causal genes and their cell-type context remain unclear. Prior work linked migraine GWAS to bulk brain eQTLs; however, tissue-average signals obscure cell-specific regulation. - Source: PubMed
Publication date: 2025/12/05
Ye HongHuang YajingWang ChengJin JianchengJiang ChaoyaFang JunjieXu Qiuhan - Lung adenocarcinoma (LUAD), a common type of non-small cell lung cancer, is associated with low survival rates and challenges in early detection. Therefore, identifying prognostic biomarkers is crucial for improving patient outcomes. This study utilized 2 datasets - the Cancer Genome Atlas-Lung Adenocarcinoma (TCGA-LUAD) and GSE72094 - along with 182 immune escape-related genes and 597 cancer-associated fibroblast-related genes. Weighted gene co-expression network analysis was used to identify module genes. Differential expression analysis of TCGA-LUAD data revealed LUAD-associated differentially expressed genes, which were then intersected with module genes to identify LUAD-specific differentially expressed immune escape-cancer fibroblast-related genes. To identify potential biomarkers and develop a risk model, univariate Cox regression, least absolute shrinkage and selection operator analysis, and multivariate Cox regression were performed. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases were used for enrichment analysis. Immune infiltration and immune cell-biomarker correlations were assessed using CIBERSORT, and the pRRophetic tool was employed to predict LUAD chemotherapeutic sensitivities. Reverse transcription-quantitative polymerase chain reaction was used to validate the expression of prognostic genes in non-small cell lung cancer. The results showed that 183 differentially expressed immune escape-cancer fibroblast-related genes were identified by intersecting 1460 module genes with 5439 differentially expressed genes. Six genes (KRT8, S100A16, COL4A3, SMAD9, MAP3K8, and CCDC146) were selected as potential biomarkers for risk modeling. Gene Ontology enrichment analysis highlighted the involvement of glucose metabolism, ion channel complexes, and channel activity-related genes. Kyoto Encyclopedia of Genes and Genomes analysis revealed pathways related to morphine addiction and protein digestion/absorption. Immune infiltration analysis identified significant differences in 9 immune cell types, including memory B cells and CD8 T cells, between risk groups. Sensitivity to chemotherapeutics, such as AZD6482, ABT-263, A-770041, and BMS-536924, was observed in LUAD. Reverse transcription-quantitative polymerase chain reaction validation results demonstrated that KRT8 and S100A16 were significantly upregulated in tumor tissues, while COL4A3 and SMAD9 expression was downregulated, which was consistent with the TCGA-LUAD database analysis. In conclusion, 6 genes (KRT8, S100A16, COL4A3, SMAD9, MAP3K8, and CCDC146) were identified as potential biomarkers, offering valuable insights into LUAD pathogenesis and therapeutic strategies. - Source: PubMed
Ma YuhuiLi XuWang XueNaSong BinGeng RuiHao YuanSu Wen - Crohn's disease (CD) is a chronic inflammatory disorder with potential progression to stricturing (B2) or penetrating (B3) phenotypes, leading to significant complications. Early identification of patients at risk for these complications is critical for personalized management. This study aimed to develop a predictive model using clinical data and a Korean-specific transcriptome-wide association study (TWAS) to forecast early progression in CD patients. A retrospective analysis of 430 Korean CD patients from 15 hospitals was conducted. Genotyping was performed using the Korea Biobank Array, and gene expression predictions were derived from a TWAS model based on terminal ileum data. Logistic regression models incorporating clinical and gene expression data predicted progression to B2 or B3 within 24 months of diagnosis. Among the cohort, 13.9% (60 patients) progressed to B2 and 16.9% (73 patients) to B3. The combined model achieved mean area under the curve (AUC) values of 0.788 for B2 and 0.785 for B3 progression. Key predictive genes for B2 included , , and , while , , and were linked to B3 progression. This integrative model provides a robust approach for identifying high-risk CD patients, potentially enabling early, targeted interventions to reduce disease progression and associated complications. - Source: PubMed
Publication date: 2025/03/23
Kim Tae-WooPark Soo KyungChun JaeyoungKim SujiChoi Chang HwanKang Sang-BumBang Ki BaeKim Tae OhSeo Geom SeogCha Jae MyungJung YunhoKim Hyun GunIm Jong PilAhn Kwang SungLee Chang KyunKim Hyo JongKim SangsooPark Dong Il - Among rare cases of teratozoospermia, MMAF (multiple morphological abnormalities of the flagellum) syndrome is a complex genetic disorder involving at least 70 different genes. As the name suggests, patients with MMAF syndrome produce spermatozoa with multiple flagellar defects, rendering them immobile and non-fertilizing, leading to complete infertility in affected men. The only viable treatment option is ICSI. What is less understood is the presence of the various types of head defects in the spermatozoa, which are consistently present. Due to the involvement of numerous genes and the limited number of patients with MMAF syndrome, research on head defects and their impact on embryonic development remains insufficiently explored. To address these questions, a comparative study was conducted under controlled experimental conditions using four knockout (KO) mouse lines targeting Cfap43, Cfap44, Armc2, and Ccdc146 genes, all associated with MMAF syndrome in humans and mice. Each KO line underwent a detailed examination of nuclear defects, including morphology, DNA compaction, chromosomal architecture, and ploidy. The study revealed significant heterogeneity among the four lineages, with the extent of defects varying depending on the lineage, ranked as Ccdc146-/- > Cfap43-/- > Armc2-/- ≈ Cfap44-/-. The developmental potential of sperm from males in each lineage was assessed by injecting them into wild-type oocytes, and embryo development was monitored up to the blastocyst stage. Sperm from all KO lines exhibited a marked decrease in supporting embryo development compared to the wild-type, with developmental failure rates ranked as follows: Ccdc146 > Cfap43 > Armc2 > Cfap44-deficient sperm. The degree of developmental failure thus correlated with the severity of nuclear defects, and zygotes produced with sperm from Ccdc146-/- and Cfap43-/- mice showed the highest rates of developmental impairment. These findings from preclinical models highlight the heterogeneous nature of MMAF syndrome, both in terms of sperm nuclear defects and developmental potentials. Genetic characterization in humans is therefore crucial for improving therapeutic counselling in affected individuals. - Source: PubMed
Muroňová JanaLambert EmelineThamwan ChanyuthWehbe ZeinaCourt MagaliChevalier GenevièveEscoffier JessicaKherraf Zine-EddineCoutton CharlesNef SergeRay Pierre FLoeuillet CorinneMartinez GuillaumeArnoult Christophe