PITX2 monoclonal antibody (M01), clone 2G6
- Known as:
- PITX2 mab (anti-) (M01), clonality 2G6
- Catalog number:
- H00005308-M01
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- PITX2 monoclonal antibody (M01) clone 2G6
Related genes to: PITX2 monoclonal antibody (M01), clone 2G6
- Gene:
- GTF2H2B NIH gene
- Name:
- general transcription factor IIH subunit 2B (pseudogene)
- Previous symbol:
- -
- Synonyms:
- DKFZP686M0199
- Chromosome:
- 5q13.2
- Locus Type:
- pseudogene
- Date approved:
- 2008-07-04
- Date modifiied:
- 2015-11-09
- Gene:
- PITX2 NIH gene
- Name:
- paired like homeodomain 2
- Previous symbol:
- IRID2, IHG2, RIEG, RIEG1, RGS
- Synonyms:
- IGDS, RS, Brx1, Otlx2, ARP1
- Chromosome:
- 4q25
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-05
- Date modifiied:
- 2016-01-27
- Gene:
- POLR1A NIH gene
- Name:
- RNA polymerase I subunit A
- Previous symbol:
- -
- Synonyms:
- DKFZP586M0122, FLJ21915, RPO1-4, RPA1
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-04-01
- Date modifiied:
- 2017-06-28
- Gene:
- TDRP NIH gene
- Name:
- testis development related protein
- Previous symbol:
- C8orf42
- Synonyms:
- INM01, TDRP1, TDRP2
- Chromosome:
- 8p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-28
- Date modifiied:
- 2015-08-26
Related products to: PITX2 monoclonal antibody (M01), clone 2G6
Related articles to: PITX2 monoclonal antibody (M01), clone 2G6
- Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy arising from parafollicular C-cells with known variations in cytomorphologic and immunophenotypic features. New neuroendocrine markers pituitary homeobox 2 (PITX2), paired-like homeobox 2B (PH-OX2B), and heart and neural crest derivatives expressed 2 (HAND2) have recently been introduced, but studies using these markers in MTC are limited. The aim of this study was to evaluate the expression and potential diagnostic utility of PITX2, PHOX2B, and HAND2 in primary and secondary MTCs and to compare their expression with chromogranin A, synaptophysin, insulinoma-associated protein 1 (INSM1), and calcitonin. - Source: PubMed
Helenius MariKalfert DavidMaleki ZahraBarkan Güliz ARossi Esther DianaCai GuopingKholová Ivana - Axenfeld-Rieger syndrome (ARS) is a rare genetic disorder characterized by anterior segment dysgenesis and secondary glaucoma, often accompanied by systemic defects. This study investigated the clinical and genetic features in four Chinese families with ARS. - Source: PubMed
Publication date: 2026/06/12
Liu ChumouZhou ZhouXu LiLiu GuoLiu NanxinHu LiTan JunkaiChen ZijieHommodova MahriFan NingHu JiaoyueLiu Xuyang - Axenfeld-Rieger syndrome (ARS) is a multisystem disorder primarily caused by mutations. While eye and dental anomalies are classic, the role of as a dosage-sensitive regulator of the human growth axis remains clinically under-recognized. We aim to elucidate the link between large-scale 4q25 microdeletions and severe growth hormone deficiency (GHD). - Source: PubMed
Publication date: 2026/06/17
Guan ShihuiWang JinyuLiu ZhenxianQi YangfanSun XiaoyuJiang KaiLin Shuangzhu - Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, characterized by rapid and disorganized electrical activity in the atria. Although traditionally attributed to aging and structural remodeling secondary to cardiovascular comorbidities, AF has a well-recognized heritable component, with genetic factors contributing substantially to disease susceptibility. This review systematically evaluates the molecular landscape of AF, focusing on genetic mutations and their functional consequences in disease development. AF-associated genes are organized into four functional modules: (1) ion channelopathies (, , , ); (2) structural myopathies (, , , ); (3) transcriptional regulators ( ); and (4) calcium handling proteins (RYR2, CASQ2, JPH2, ANKB, PLN, TRDN). For each gene, population prevalence and penetrance of associated variants are discussed alongside the specific molecular and biophysical consequences of causative mutations. By elucidating how these protein alterations converge on shared electrophysiological and structural substrates, we provide a framework for transitioning from generalized therapeutic strategies to precision medicine approaches in cardiac electrophysiology. - Source: PubMed
Publication date: 2026/05/29
Hinge Dilip DShelke AbhijeetKawade RameshPatil Satish - The salmon trout or rainbow trout (Oncorhynchus mykiss) is a teleost fish are characterized by the presence of lingual teeth. The objective of this study is to investigate their development, particularly in relation to the expression of genes associated with mammalian odontogenesis. Sixty fry were reared in a freshwater aquarium at 7°C. Specimens at developmental stages ranging from D0 (hatching) to D35 were collected and subjected to histological (Masson's trichrome) and immunohistochemical analysis, including the expression of proteins associated with the Pitx2, Shh, MSX1, Pax9, Bmp4 and β-catenin genes. The developmental patterns of the lingual teeth are similar to those of the maxillary and mandibular teeth. These are not giant papillae or pseudoteeth. The initiator gene Pitx2 is expressed in the epithelium during early stages but subsequently diminishes. Bmp4, Shh and β-Cat exhibit a pattern similar to that of mammals, except for the absence of the enamel node. Surprisingly, however, we observe expression of Msx1 and Pax9 in the dental mesenchyme as well as in the epithelium, a phenomenon unknown in mammals. The second week marks an increase in the expression of these two proteins and of Shh, while Bmp4 does not appear in large quantities until 10 days. Incidentally, the mucous glands (cement glands) express Shh, Pitx2, Msx1, Pax9 and β-catenin. In conclusion, tongue teeth are 'classical' teeth; their gene expression patterns are similar to those in mammals, except that Msx1 and Pax9 are expressed in both epithelial and mesenchymal tissues in this species. - Source: PubMed
Louryan StéphaneDuterre MyriamVanmuylder Nathalie