SERPINA3 antibody
- Known as:
- SERPINA3 (anti-)
- Catalog number:
- orb129738
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- SERPINA3 antibody
Related genes to: SERPINA3 antibody
- Gene:
- SERPINA3 NIH gene
- Name:
- serpin family A member 3
- Previous symbol:
- AACT
- Synonyms:
- ACT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-04
Related products to: SERPINA3 antibody
Related articles to: SERPINA3 antibody
- This study aimed to investigate the spatial cellular architecture and molecular interactions in healthy and inflamed dental pulp using spatial transcriptomics (Visium HD), to elucidate the pathological mechanisms of pulpitis and identify potential therapeutic targets for vital pulp therapy. - Source: PubMed
Publication date: 2026/06/15
Zhang FengyuanKong YuanyuanFu XiaobinZuo JiyuanGuo QiningWang JiayiXu ManlinZeng QianZhang YuejiaoLing JunqiJiang QianzhouWei XiZheng Jianmao - Missed miscarriage is a frequent form of early pregnancy loss, yet its pathophysiology remains incompletely understood and sensitive blood-based biomarkers for detection of established missed miscarriage are limited. - Source: PubMed
Publication date: 2026/05/29
Jiang YapingSong AnnaLiu TaoNie XiaoqianWang HuiZhao LiKong QiaoqiaoLou HuanyingWang LingmeiWang HaifengZhang Bo - Preeclampsia (PE) is a pregnancy complication involving immune dysregulation. This study aims to identify diagnostic immune biomarkers for PE using machine learning. mRNA expression profiles from GSE75010 and immune-related genes from ImmPort were analyzed. Differentially expressed immune-related genes (DIRGs) were identified and subjected to GO/KEGG enrichment, PPI network, LASSO, and mSVM-RFE analyses. Candidate biomarkers were validated in additional GEO datasets (GSE54618, GSE74341, GSE147776) and by RT-PCR, Western blot, and immunohistochemistry in placental tissues. Immune cell infiltration was evaluated using CIBERSORT. Ten DIRGs were identified between PE and normotensive pregnancies. GO/KEGG analyses highlighted cytokine-cytokine receptor interactions. SERPINA3 and NDRG1 were identified as diagnostic biomarkers (AUC = 0.812 and 0.866 in training set; 0.798 and 0.781 in test set). Elevated expression of SERPINA3 and NDRG1 was confirmed in PE placental tissues. Immune analysis revealed that both genes were negatively correlated with M2 macrophages. SERPINA3 and NDRG1 are critical immune-related diagnostic biomarkers for PE and are associated with M2 macrophage reduction, providing novel insights into PE pathogenesis and diagnosis. - Source: PubMed
Publication date: 2026/06/10
Wu ZhunaChen ShihongChen WeihongXie YajingZhou ZhimeiHuang LiWang YueliChen BinbinYang CongmeiKe Yumin - Sepsis accounts for nearly 20% of global mortality, with antibiotic resistance worsening clinical outcomes. Rapid antibiotic administration and accurate pathogen identification remain crucial. It is well now known that extracellular vesicles (EVs) from human cells and bacterial membrane vesicles (bMVs) play a central role in the interaction between host and pathogen and represent promising biomarkers for early infections. This study investigated how antibiotic exposure alters EV responses in Staphylococcus aureus (SA)spiked blood and compared these findings with EV proteome profiles from bacteremia patients. In an in vitro model, whole blood from healthy donors was spiked with SA at a multiplicity of infection (MOI) of 0.001, treated with clinically relevant concentrations of piperacillin-tazobactam, vancomycin, or moxifloxacin, and plasma was subsequently isolated for EV analysis. EVs were isolated using the Miltenyi Pan EV Kit and analyzed by bead-based flow cytometry and high-resolution LC-MS/MS. In parallel, serum EVs from healthy controls (n = 6) and bacteremia patients (n = 12; 6 blood culture-positive and 6 culture-negative) were analyzed using the same workflow. Flow cytometry revealed increased levels of CMO⁺ CD45⁺ PanEV⁺ SA⁺ vesicles in SA-spiked samples, particularly following low-dose piperacillin-tazobactam and high-dose vancomycin treatment, despite minimal changes in vesicle size and total particle counts. Proteomic analysis of plasma EVs showed significant alterations in protein composition, including increased abundance of the SA-derived ribosomal protein rplU and host defense-associated proteins. Functional enrichment highlighted pathways related to neutrophil degranulation, vesicle-mediated transport, and antibacterial responses. In patient samples, serum EVs were enriched in acute-phase and immune-related proteins, including SERPINA1, SERPINA3, CRP, and SAA2, along with canonical EV markers such as CD81 and syntenin-1, irrespective of blood culture status. Antibiotic exposure and SA infection are associated with measurable changes in the human EV proteome, characterized by enrichment of immune and host defense-related proteins despite stable vesicle numbers. Similar EV-associated protein patterns were observed in both blood culture-positive and -negative patient samples, reflecting shared features of the systemic host response to infection and highlighting the potential of EV profiling to capture infection-associated biological signals. - Source: PubMed
Publication date: 2026/05/30
Chiang Dapi MenglinPfaffl Michael WSchelling GustavMeidert Agnes SBrandes FlorianLudwig ChristinaWudy Susanne IKirchner BenediktYu Mia S CZenner ChristianUlbricht RosalieMuller LaurentReithmair Marlene - Neoadjuvant immunochemotherapy (nICT) has emerged as a promising strategy for locally advanced gastric cancer (LAGC), yet clinical responses remain heterogeneous and reliable predictive biomarkers are lacking. A comprehensive dissection of the tumor microenvironment (TME) is essential to uncover determinants of therapeutic efficacy and enable precision immunotherapy. - Source: PubMed
Publication date: 2026/05/14
Xu XiaohongFan JunPeng LiXiang ZhengkaiLuo DanjuMa ChenggongHuang BoNie XiuDong Xiaochuan