PGLS antibody
- Known as:
- PGLS (anti-)
- Catalog number:
- orb126243
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- PGLS antibody
Related genes to: PGLS antibody
- Gene:
- PGLS NIH gene
- Name:
- 6-phosphogluconolactonase
- Previous symbol:
- -
- Synonyms:
- 6PGL
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-20
- Date modifiied:
- 2015-08-25
Related products to: PGLS antibody
Related articles to: PGLS antibody
- Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition receptors that play a crucial role in the innate immune response of animals. Their evolutionary dynamics are closely linked to pathogen pressure and environmental factors. At present, the relationship between the evolution of genes and climatic factors remains poorly understood. In this study, we identified - genes from 42 rodent species with relatively restricted distribution ranges. Phylogenetic comparative analyses, including phyANOVA and PGLS, were conducted to assess the relationship between evolutionary rates ( values) and 10 climatic factors. The results indicated that different genes exhibit distinct climate-associated patterns. Notably, increased precipitation-related factors were positively associated with the evolutionary rates of and , whereas temperature-related factors (Mean Diurnal Range) were positively correlated with the evolutionary rates of and . We hypothesized that both precipitation- and temperature-related factors may indirectly influence the evolution of genes by affecting the diversity and community composition of environmental pathogens. These results may enhance our understanding of the evolution of immune genes in animals through the perspective of potential ecological associations. - Source: PubMed
Publication date: 2026/09/01
Zhao ChaoXia TianLiu GuangshuaiLiu ZhaoDing XingleiDai ShuoZhang Honghai - Maximum longevity varies widely among marine-occurring fishes, but the form of its relationship with body size and the contribution of broad environmental gradients remain uncertain. We analysed 757 species, using maximum length as the primary size metric and completed mass only in sensitivity analyses. A quadratic length model improved fit over a linear comparator and captured broad attenuation in the size-longevity association. Maximum depth was positively associated with log10 maximum longevity after accounting for this curvature (estimate per 1000 m = 0.0692, 95% CI 0.0312 to 0.1072, p < 0.001). Latitude estimates varied among range-based metrics and model specifications, and the latitude term performed less consistently when entire families and orders were withheld. None of the group or continuous-interaction contrasts met the defined FDR threshold of q < 0.05. FishTree matched 605 species but excluded every elasmobranch in the canonical dataset; branch-length phylogenetic generalized least squares (PGLS) therefore provides a matched-subset sensitivity rather than full phylogenetic coverage. Linear contrasts from 5000 species-level bootstrap resamples and nonlinear quantile sensitivities did not indicate broad upper-tail steepening. Teleostei-only, broad-Class-adjusted and Family-clustered analyses retained a positive maximum-depth coefficient, whereas latitude was less stable under clustered uncertainty. Body size and maximum depth thus provide the most consistent macroecological associations with maximum longevity. Latitude remains exploratory, and the data do not identify causal mechanisms. - Source: PubMed
Publication date: 2026/08/30
Li LongyuXu Zenghui - Paragangliomas (PGLs) are rare neuroendocrine tumors arising from extra-adrenal chromaffin cells, with head and neck paragangliomas (HNPGLs) accounting for only a small proportion of all cases. Although most HNPGLs are benign, slow-growing, and nonfunctional, a minority develop metastatic disease, for which reliable histopathologic predictors remain lacking. We report the case of a 63-year-old man who presented with a progressively enlarging left-sided neck mass that had been present for more than 30 years before evaluation. Imaging demonstrated a carotid body paraganglioma with cervical lymph node involvement and distant suspected metastases to the thoracic and lumbar spine, lung, salivary gland, shoulder soft tissue, and small bowel. Histopathology confirmed paraganglioma with classic Zellballen architecture and positive staining for synaptophysin, chromogranin-A, CD56, GATA3, and S100-positive sustentacular cells. Given the patient's minimal symptoms despite extensive metastatic disease, a multidisciplinary team initially pursued active surveillance with serial multimodal imaging. Radiographic progression over time prompted initiation of systemic therapy with cabozantinib, which resulted in decreased metabolic activity of the primary tumor and no fluorodeoxyglucose-avid evidence of metastatic disease on follow-up imaging. This case highlights the unpredictable biological behavior of carotid body paragangliomas, demonstrating that longstanding, minimally symptomatic tumors may ultimately progress to widespread metastatic disease. It further emphasizes the importance of prolonged surveillance, multimodal imaging, multidisciplinary management, and individualized treatment strategies for patients with metastatic HNPGLs in the absence of reliable predictors of malignant potential. - Source: PubMed
Publication date: 2026/08/28
Parkhurst Erik LHamad Amar - Pheochromocytomas and paragangliomas (PPGLs) are rare and mostly non-metastatic tumors originating from adrenal medulla and paraganglia. Metastatic PGLs have a worse prognosis, but currently, there are no established criteria to determine PPGL metastatic potential. - Source: PubMed
Publication date: 2026/08/24
Gunnesson LisaKarakaya SinanMohlin SofieMuth AndreasElias Erik - Environmental temperature is a major ecological factor shaping physiological and molecular evolution in mammals. Fatty acid desaturase genes ( and ) play essential roles in the biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), which are critical for membrane structure and metabolic regulation. However, their evolutionary responses to climatic variation in wild mammals remain poorly understood. In this study, we analyzed 27 rodent species distributed across diverse climatic regions to investigate the relationship between environmental temperature and the evolutionary rates of the and genes. Phylogenetic comparative methods, including phylogenetic ANOVA, phylogenetic generalized least squares (PGLS), and branch model analyses, were applied to estimate ω (dN/dS) ratios and assess selection patterns. Branch-site model analyses were further performed to test for episodic positive selection acting on specific codons in low-temperature-associated lineages. Our results showed that species inhabiting lower-temperature environments exhibited significantly higher ω values for both genes compared with those in warmer environments. PGLS analyses revealed consistent negative associations between temperature variables and evolutionary rates, particularly for BIO5, and branch model analyses further indicated elevated ω values in low-temperature-associated lineages relative to background branches. Branch-site analyses detected significant signatures of episodic positive selection in and , with candidate positively selected codons identified in both lineages. Similar temperature-associated evolutionary rate patterns were also observed in expanded mammalian datasets, suggesting a broader cross-taxa trend. Overall, these findings indicate that environmental temperature is associated with heterogeneous evolutionary rate patterns in genes and suggest that lipid metabolism genes may be recurrently influenced by cold-related selective pressures across mammals. - Source: PubMed
Publication date: 2026/08/20
Zhao ChaoLiu ZhaoDing XingleiXia TianDai ShuoLiu GuangshuaiFang JiaohuiZhang Honghai