GABRE antibody
- Known as:
- GABRE (anti-)
- Catalog number:
- orb140389
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- GABRE antibody
Related genes to: GABRE antibody
- Gene:
- GABRE NIH gene
- Name:
- gamma-aminobutyric acid type A receptor epsilon subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1997-03-19
- Date modifiied:
- 2016-02-04
Related products to: GABRE antibody
Related articles to: GABRE antibody
- The trial aimed to study the additive effect of domiciliary professional dental cleaning on root caries lesions (RCLs), oral hygiene outcomes and oral health-related quality of life (OHRQoL) in care-dependent older adults with in-home care that use high fluoride toothpaste, compared with oral care as usual for a year. Parallel-group evaluator-blinded randomized controlled trial. Participants own home in Sweden. 194 care-dependent with in-home care aged ≥65 years and ≥1 natural tooth were randomized (1:1) in blocks by computer-generated sequence. 149 were available at baseline (intervention (I) = 80, control (C) = 69). All were provided with toothbrushes and high-fluoride toothpaste (5,000 ppm F) for daily use. Domiciliary professional dental cleaning and oral hygiene instructions by dental assistant, every third month. The primary outcome was RCLs progression. Secondary outcomes were gingival bleeding, oral hygiene, hyposalivation and OHRQoL, registered at baseline and after 1 year by dental hygienists. Due to high attrition (45%), 82 individuals remained (I = 50, C = 32) after 1 year resulting in an underpowered study. The number of subjects assessed with RCLs progression was 11 (22.0%) in I group and 9 (28.1%) in C. With the use of per protocol analysis, no significant differences between groups were seen for any of the outcomes. Domiciliary professional dental cleaning to care-dependent older adults does not seem to have any additive preventing effect on RCLs to daily toothbrushing with high-fluoride toothpaste. This suggests that focus be maintaining good daily oral health routines rather than home-care visits to maintain oral health. - Source: PubMed
Publication date: 2026/08/12
Morén ElisabethGabre PiaSjögren PetteriWårdh IngerSkott Pia - The development of multifunctional antimicrobial materials capable of targeting both planktonic bacteria and biofilm-associated infections remains a critical challenge in combating antimicrobial resistance. In this study, a novel piperazine-linked chitosan Schiff base (Cs-TPA-PiP) and its ionically crosslinked nanoparticle formulation (Cs-TPA-PiP NPs) were synthesized and structurally characterized. The antimicrobial potential of both Cs-TPA-PiP and Cs-TPA-PiP NPs was evaluated against a panel of nine standard clinically significant bacterial strains. The compounds demonstrated significant and broad-spectrum antibacterial activity. The minimum inhibitory concentration (MIC) values demonstrated potent efficacy, with Cs-TPA-PiP and its Cs-TPA-PiP NPs ranging from 0.63 to 2.50 mg/mL and 1.00-5.00 mg/mL, respectively. Notably, both agents exhibited a strong dose-dependent inhibitory effect on biofilm formation. While Cs-TPA-PiP showed lower MIC values against planktonic cells, the corresponding Cs-TPA-PiP NPs with an ultra-small spherical size of 15.6 nm exhibited superior antibiofilm performance, ranging from 73.00% to 95.00% inhibition of biofilm biomass at 1× MIC in strong biofilm-producing strains. Transmission electron microscopy (TEM) confirmed severe morphological alterations and membrane disruption in treated bacterial cells, consistent with a membrane-targeting mechanism. In silico molecular docking studies suggested that the compound has favorable binding affinity for the critical bacterial cell wall target, Sortase A, thereby identifying it as a potential theoretical target requiring further validation. Our findings collectively establish Cs-TPA-PiP and its Cs-TPA-PiP NPs as effective antibacterial and anti-biofilm candidates, with their activity primarily attributed to membrane disruption. The proposed role of Sortase A inhibition remains hypothetical and warrants further investigation. These findings highlight their potential as multifunctional antibacterial platforms for managing biofilm-associated and resistant bacterial infections. - Source: PubMed
Publication date: 2026/08/06
Soliman Mona MBayoumy Abdelrahman EssamHamed Amira AGabre Refaat MAbd-Elhakeem Mohamed AAbdelhamid Ismail AElgamal Ahmed M - Sodium overload has recently emerged as a critical metabolic stressor involved in cancer progression; however, its molecular characteristics and clinical relevance in acute myeloid leukemia (AML) remain unexplored. RNA-seq data sets, clinical annotations, and mutational profiles of AML patients were annotations from The Cancer Genome Atlas and integrated with Genotype-Tissue Expression normal samples. Sodium overload-related genes (SORGs) were obtained from GeneCards. Differentially expressed SORGs (DESORGs) screened by applying the limma statistical model, followed by univariate Cox proportional hazards regression, consensus clustering, functional enrichment, immune infiltration analysis, and pathway evaluation. A prognostic signature was developed through least absolute shrinkage and selection operator regression followed by multivariate Cox modeling. The model's performance was further verified in two external GEO data sets (GSE71014 and GSE37642). Nomogram construction, subgroup analysis, tumor mutational burden (TMB) assessment, drug sensitivity prediction, transcription factor (TF) analysis, and competing endogenous RNA (ceRNA) network analyses were also performed. A total of 57 DESORGs were identified, and 2 sodium overload-related molecular subtypes exhibited distinct survival, immune infiltration, and inflammatory pathway activation. A robust four-gene signature (DOCK1, GABRE, HTR7, ACSM1) stratified patients into high- and low-risk categories with significantly different survival across training and validation cohorts. High-risk patients displayed increased immune infiltration, higher TMB, reduced sensitivity to multiple chemotherapeutic drugs, and inferior predicted response to PD-L1 blockade. TF and ceRNA networks revealed multilayered transcriptional and post-transcriptional regulation of the signature genes. This study identifies sodium overload-related molecular heterogeneity in AML and establishes a validated four-gene prognostic signature that integrates genomic, immunologic, and therapeutic features, offering potential utility for personalized risk assessment and treatment optimization. - Source: PubMed
Publication date: 2026/08/01
Wang YuanYang Yi - Acute myeloid leukemia (AML) features high biological heterogeneity and unfavorable prognoses, demanding reliable prognostic biomarkers. Dysregulated post-translational modifications (PTMs) drive AML progression by disrupting protein function and cellular signaling. This work constructed a PTM-based risk signature to predict AML survival and dissect the tumor immune microenvironment. - Source: PubMed
Publication date: 2026/07/23
Gan DonghuiZeng JinfangLin JunChen XiaojunHuang MengtingWeng DanYan Jun - Asymptomatic bacteriuria (ASB) in diabetic postmenopausal women represents a critical yet under-monitored reservoir for multidrug-resistant (MDR) uropathogens. In regions with high antibiotic selection pressure, like Libya, the emergence of carbapenem-resistant Enterobacterales (CRE) threatens the efficacy of last-resort therapeutic options. This study aimed to characterize the phenotypic and genotypic resistance landscapes of Escherichia coli and Klebsiella pneumoniae isolates obtained from this specific risk population. - Source: PubMed
Publication date: 2026/07/22
Ashur Abir BenGashout AishaAbou-Aisha KhaledSalem Abeer MGabre Refaat M