BFAR antibody
- Known as:
- BFAR (anti-)
- Catalog number:
- orb100008
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- BFAR antibody
Related genes to: BFAR antibody
- Gene:
- BFAR NIH gene
- Name:
- bifunctional apoptosis regulator
- Previous symbol:
- -
- Synonyms:
- BAR, RNF47
- Chromosome:
- 16p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-29
- Date modifiied:
- 2016-10-05
Related products to: BFAR antibody
Related articles to: BFAR antibody
- Raw Atractylodis Rhizoma (RAR) is a traditional Chinese medicine that has multiple effects and is effective in treating ulcerative colitis (UC). Bran-fried Atractylodis Rhizoma (BFAR) is a commonly processed preparation and has better therapeutic effects on UC. However, the underlying changes in the chemical composition of bran-fried RAR and molecular mechanisms related to UC remain unclear. In this study, GC-MS analysis was employed to identify the chemical constituents of RAR and BFAR, and network pharmacology combined with molecular docking was used to elucidate their potential mechanisms of action against UC. A total of 95 components were identified. Comparative analysis revealed that bran-fried significantly altered the chemical profile of RAR, with 2,6,11-trimethyldodecane and elemol identified as key compounds whose contents markedly decreased after processing. Network pharmacology analysis screened 38 active components and 201 common targets. Enrichment analysis indicated that their functions are closely related to the PI3K-Akt signaling pathway and cancer pathways, with BFAR exhibiting a broader component-target interaction network than RAR. Molecular docking validated strong binding activity between the core active components and key targets. These findings provide a robust theoretical foundation and data support for standardizing processing techniques, quality control, and clinical application of RAR and BFAR. - Source: PubMed
Xun GeZhang XiaoguangCheng JieXiang CongkunLi YingxuanWang JianxiaLv TaoZhang WeiZhang LipingZhang ZishangFu YanWang QiaoChen Jiong - Gnathiid isopods are the most prevalent and ecologically important temporary ectoparasites of coral reef fishes and are important for supporting the functional integrity of coral reefs. Through their role as parasites, gnathiids can influence community dynamics in their ecosystem. The family Gnathiidae constitutes 12 genera, including the genus Elaphognathia that can be distinguished from other genera by the deeply excavated frontal border, dramatic lengthening of the mandibles, and addition of apical cusps in adult males. There are currently 25 known species of Elaphognathia described over a period of 130 years, with only five species molecularly characterized. The present study contributes to the knowledge of this genus by providing a comprehensive integrative description of the 26th species of Elaphognathia, the first novel gnathiid species described from the Philippines. Larval gnathiids were collected in the Central Indo-Pacific (Philippines), using light traps, separated, kept alive to molt into adults, and preserved in 95% ethanol for morphological and molecular characterization. Species description was based on light and scanning electron microscopy of the adult male, prepared in the program DEscriptive Language for Taxonomy (DELTA), using a modified Gnathiidae character set. Key distinguishing features of the new species are the presence of a pseudoblade, with the anterior tip dorsally visible, a large, rounded inner lobe with semi-smooth ridges, and conical protrusions on the inferior (dorsal) and superior (ventral) margin of the mandible, as well as the excavated frontal margin with two equal superior frontolateral processes with sinuate superolateral margins. The novel species can be distinguished from other molecularly characterized Elaphognathia (E. sugashimaensis and E. rangifer) by ~27% variation in COI sequences. More molecular data are required in order to elucidate a more accurate phylogenetic analysis of this genus. - Source: PubMed
Publication date: 2026/01/31
Yumul KimSmit Nico JHadfield Kerry AShodipo Mary OSikkel Paul CErasmus Anja - The immunosuppressive tumor microenvironment remains a major barrier to effective immunotherapy in gastric cancer. In this study, we identified the E3 ubiquitin ligase BFAR as a critical regulator of neutrophil-mediated immune evasion through the S100A8/A9-BFAR-PRP19-YBX1 signaling axis. Multiomics analyses revealed that BFAR is overexpressed in gastric cancer and correlates with poor prognosis. Functional studies demonstrated that BFAR knockdown suppressed tumor growth by reducing neutrophil infiltration and immunosuppressive reprogramming to restore CD8+ T-cell function. Mechanistically, BFAR mediated K48-linked ubiquitination and degradation of PRP19, leading to stabilization of the oncoprotein YBX1, which transcriptionally upregulated neutrophil-recruiting chemokines CXCL1/CXCL3. Infiltrating neutrophils secreted S100A8/A9, which activated NF-κB to induce BFAR expression in tumor cells and created a feed-forward loop that sustains an immunosuppressive tumor microenvironment. Furthermore, BFAR promoted neutrophil PD-L1 expression via GM-CSF, reinforcing T-cell exhaustion. Clinically, BFAR expression correlated with neutrophil infiltration and poor response to anti-PD-1 therapy, whereas its inhibition synergizes with immune checkpoint blockade in preclinical models. Our work unveils BFAR as a central orchestrator of neutrophil-driven immunosuppression and proposes targeting this axis to enhance immunotherapy efficacy in gastric cancer. - Source: PubMed
Ma XinLiu YumeiChen YingyingWang JuanZhang FeiyueLiang WeiZhang PengboZhou YunlanMiao BeiFei SujuanYamamoto MasamiTsukamoto TetsuyaNomura SachiyoLi LiWang Jiajia - By integrating Fourier transform microwave spectroscopy with quantum chemical calculations, a detailed conformational and structural analysis of the benzofuran (BF) complexes with argon (BF-Ar) and krypton (BF-Kr) is conducted. The conformations of each complex are explored utilizing the Conformer-Rotamer Ensemble Sampling Tool method for conformational searches, with subsequent geometry optimizations using MP2, RI-SCS-MP2, and density functional theory methods. Experimental results corroborate that the most stable conformations for both complexes feature the rare gas (Rg) atom positioned above the BF ring. In particular, Ar and Kr atoms prefer to locate above the C5 atom, with the Rg···C5 line nearly perpendicular to the BF plane. The Ar and Kr atoms are located ≈3.491 and 3.580 Å from the center of mass of BF. The natural bond orbital analysis indicates that the second-order perturbation energy for the Rg···π interaction is about 3.1 and 3.0 kJ mol in the BF-Ar and BF-Kr complexes, respectively. Symmetry-adapted perturbation theory energy decomposition analysis reveals that dispersion forces are predominant in these complexes. This study provides insights into the nature of van der Waals interactions between bicyclic heteroaromatics and Rg. - Source: PubMed
Publication date: 2025/09/14
Lv WenqiZhang JiaqiEvangelisti LucaFeng GangCaminati Walther - The progression of inflammation during sepsis represents a multifaceted biological cascade that requires effective therapeutic interventions to improve survival. In septic neonatal foals, oxidative stress (OS) arises due to a compromised antioxidant defense system. Oxidative stress may disrupt the functionality of redox-sensitive organelles, such as the endoplasmic reticulum (ER). Endoplasmic reticulum stress disorder affects multiple cellular signaling pathways, including redox balance, inflammation, and apoptosis, and contributes to the pathogenesis of sepsis. The study aimed to elucidate whether OS conditions in sepsis influenced gene expression associated with ER stress. Blood samples were collected from 7 healthy and 21 hospitalized neonatal foals and processed for RNA extraction. RNA sequencing was employed to identify ER stress-responsive genes. Novel findings reported here indicate activation of the ER stress pathway in foals with sepsis. Several genes associated with ER stress, such as clusterin (), BCL2-like 1 (), ubiquitin specific peptidase 14 (), bifunctional apoptosis regulator (), and optic atrophy 1 (), were upregulated and positively correlated with sepsis scores and negatively correlated with the combined activities of antioxidant enzymes. In contrast, X-box binding protein 1 (), homocysteine inducible ER protein with ubiquitin-like domain 1 (), leucine-rich repeat kinase 2 (), and selenoprotein S () were negatively correlated with sepsis scores and were downregulated in sepsis and positively correlated with the combined activities of antioxidant enzymes. Furthermore, a positive correlation was observed between cAMP responsive element binding protein 3 like 2 () and , as well as between the expressions of and YOD1 deubiquitinase () in sepsis. Similarly, the expression levels of and demonstrated a positive correlation with each other in sepsis. Additionally, the downregulation of genes with protective function against OS, such as , , and , in septic foals also highlights their significance in mitigating OS in sepsis treatment. The study reported here highlights the potential of ER stress as a promising therapeutic target and prognostic marker in septic foals. - Source: PubMed
Publication date: 2025/08/21
Sahoo Dipak KumarWong DavidPaital BiswaranjanRuby Rebecca EPatel Ashish