XKR1 antibody
- Known as:
- XKR1 (anti-)
- Catalog number:
- orb100032
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- XKR1 antibody
Related genes to: XKR1 antibody
- Gene:
- XK NIH gene
- Name:
- X-linked Kx blood group
- Previous symbol:
- NA, NAC
- Synonyms:
- XKR1, Kx, X1k
- Chromosome:
- Xp21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: XKR1 antibody
Related articles to: XKR1 antibody
- Tumor-infiltrating B cells (TIBs) are emerging as central regulators of anti-tumor immunity, but their biological functions, spatial niches, and cross talk with tumor-infiltrating lymphocytes vary widely across cancer types, particularly with regard to cancer immunotherapies. Yet a pan-cancer atlas linking their transcriptional profile to the immune checkpoint blockade (ICB) response has been missing. Here, we presented the pan-cancer ICB response B cell atlas, constructed from 688 single-cell transcriptomes (24 cancer types, 241,645 cells). Twenty-four B cell subsets were identified, and their proportion dynamics and transcriptomic features across cancers were revealed. B cell subsets proportion-based NMF analyses identified 5 TIME subtypes in which TIME-Plasma and TIME-Memory showing repressed apoptosis, higher antigen presentation, and enrichment in responders were correlated with better survival in several cancers. Pseudo-time trajectories delineated two conserved differentiation pathways that branch at the memory B cell node and showed distinct correlations with B cell apoptosis and ICB response. Pan-cancer spatial deconvolution showed that several responder-derived B cell subsets including plasma cells, memory B cells, and activated B cells were more co-occurred compared to non-responder-derived B cell subsets. Utilizing pan-cancer TCGA datasets, the clinical heterogeneity of B cell subsets from distinct response groups was revealed. We constructed a pan-cancer ICB response Geneformer model and in silico perturbed all genes. Thirteen candidate genes, which were significantly correlated with the B cell ICB response state transition, were identified. Overall, our study illuminates the heterogeneity of TIBs and improves our understanding of cancer-specific B cell subsets within the context of tumor immunotherapies. - Source: PubMed
Publication date: 2026/06/05
Fang JialingLiu HangyuLei JunChen YongshunWang Jingjing - Maize is a vital grain and forage crop with continuously increasing yield demands, making the improvement of plant architecture for high-density planting particularly significant. Among architectural traits, leaf angle (LA) is a key factor influencing light interception and canopy architecture. To dissect the genetic basis of LA in maize, a genome-wide association study was conducted. - Source: PubMed
Publication date: 2026/06/03
Li KeyuXie JiaCao JinghanWang ChangjinHe WangfeiShe RenjieBao RuzhenChai YuchenYu HaozeHan YuHuang WeidongCheng XinxinCui MingliangChen LeiYu Haibing - Passage behaviour at barriers of migratory fish is well studied in rivers, whereas little is known about fish movement at estuarine barriers. In response to climate change, more estuarine barriers are likely to be erected in the future, further compromising connectivity for diadromous fish. As these fish species are already severely endangered, there is an urgent need to better understand passage behaviour at barriers to facilitate connectivity. These fish face challenges at estuarine sluice gates, where suitable passage windows occur only infrequently. To enhance fish migration, sluice management at the Haringvliet barrier, located at the mouth of the Rhine and Meuse rivers, was recently adjusted to allow controlled inflow from the sea ("Kier management"). We assessed upstream passage windows for large anadromous fish prior to this adjustment, using long-term (1996-2018) telemetry (NEDAP Trail System) and environmental data. Of 1,751 tagged Atlantic salmon (Salmo salar), sea trout (Salmo trutta), and sea lamprey (Petromyzon marinus), 516 (29%) entered the rivers and for 68 fish we could determine the exact conditions during sluice passage. Our results show the barrier effect of the sluices and indicate the importance of river discharge to attract anadromous fish. Sluices discharged only during low tide, with flow velocities depending largely on water level differences between Haringvliet and the sea. Fish passage occurred primarily (72%) at the end of discharge periods, when the incoming tide reduced water level differences and flow velocities were lowest. Our findings also underline species-specific differences in passage conditions. Sluice passage for salmon and sea trout was limited to daylight hours, whereas sea lamprey showed no diel preference. Sea trout took, on average, more time between release and successful passage and showed a wider range in conditions, while sea lamprey had a limited seasonal range, and salmon appeared most selective in their passage conditions. The frequency of windows in time with potential passage conditions was strongly limited for all species under these unnatural conditions. These findings highlight the need for species-specific management to enhance connectivity at estuarine barriers. We recommend prolonging sluice openings during small water level differences to improve upstream passage for anadromous species. - Source: PubMed
Publication date: 2026/05/30
Meijer Zu Schlochtern Melanie PNagelkerke Leopold A JBuijse Anthonie DVriese F TimBreukelaar André WHop JochemWinter Hendrik V - Ion permeation through bilayer lipid membranes (BLMs) is a fundamental process governing the transport of ionic drugs across biological membranes. In this study, we experimentally demonstrated that water-soluble but hydrophobic anions (HS-BODIPY) can be accumulated inside giant unilamellar vesicles (GUVs) by utilizing concentration gradients of driving cations (X). By varying the cation species (X = K, Na, CHNH, (CH)NH, (CH)NH, and (CH)N), the accumulation of HS-BODIPY strongly depended on both the species and concentration of X. Hydrophilic cations such as Na and K also acted as driving ions in neutral GUVs, likely through affinity with phosphate or carbonyl groups of phospholipid headgroups. Furthermore, incorporation of cationic lipids enhanced the accumulation of HS-BODIPY, whereas anionic lipids had little effect. These findings demonstrate that ion-pair distribution into BLMs and cation-lipid interactions play crucial roles in governing membrane permeability of ionic species. The mechanism revealed here offers a novel and biocompatible strategy for controlling ion transport and encapsulating anionic drugs such as nucleic acids and nucleotides into liposomal systems. - Source: PubMed
Publication date: 2026/05/28
Nakabayashi KoheiFujihara HibikiYamamoto KaiYanai HikaruZhu WenliangMiura YumaSotoma ShingoMaeda KohjiYoshida Yumi - To investigate the activity characteristics of distinct androgen metabolic pathways in patients with 21-hydroxylase deficiency (21OHD) and their correlation with disease control status, and to elucidate the metabolic pathway features and underlying mechanisms in poorly controlled patients. - Source: PubMed
Publication date: 2026/05/11
Chong HemengPi YaleiZhang YananLi YuqianXing YutongZhang Huifeng