LOXL4 antibody
- Known as:
- LOXL4 (anti-)
- Catalog number:
- orb100094
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- LOXL4 antibody
Related genes to: LOXL4 antibody
- Gene:
- LOXL4 NIH gene
- Name:
- lysyl oxidase like 4
- Previous symbol:
- -
- Synonyms:
- FLJ21889, LOXC
- Chromosome:
- 10q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-11-14
- Date modifiied:
- 2016-10-05
Related products to: LOXL4 antibody
Related articles to: LOXL4 antibody
- Hepatocellular carcinoma (HCC) typically progresses within a fibrotic, collagen-rich microenvironment where extracellular matrix (ECM) remodeling critically dictates tumor malignancy. However, the cell-type-specific contributions of the lysyl oxidase (LOX) family to this remodeling remain poorly understood. In this study, we conducted an integrative transcriptomic analysis of the LOX gene family (LOX, LOXL1-4) in HCC. Bulk RNA-seq analysis revealed that LOX, LOXL2, and LOXL4 were significantly upregulated in tumors and correlated with advanced pathological stages and poor prognosis. Single-cell RNA-seq (scRNA-seq) analysis delineated distinct expression landscapes: LOX and LOXL4 were enriched in malignant cells, while LOXL2 was predominantly expressed in fibroblasts and endothelial cells. Notably, we identified a discrete LOXL2⁺ fibroblast subset characterized by transcriptomic programs associated with ECM remodeling, contractility, angiogenesis, and hypoxia. A signature derived from LOXL2⁺ fibroblasts was significantly associated with inferior overall survival and enhanced epithelial-mesenchymal transition (EMT) activity in the TCGA-LIHC cohort. Intercellular signaling analysis (CellChat) demonstrated that LOXL2⁺ fibroblasts engage in robust crosstalk with malignant cells via collagen/periostin-integrin signaling axes. Finally, STIP1 was identified through LASSO and random survival forest models as a critical prognostic effector within the LOXL2⁺ fibroblast program. Our findings establish LOXL2⁺ fibroblasts as a pivotal stromal subset driving malignant remodeling and provide potential therapeutic targets for HCC. - Source: PubMed
Publication date: 2026/05/30
Chen HaijunZhu LujianLin JunmeiYe XuxingHua HongjunYang ChaoWang Xiaobo - Radiotherapy (RT) resistance in glioma is closely linked to abnormal JAK/STAT signaling, but its upstream drivers are unclear. This study investigates the role of lysyl oxidase-like 4 (LOXL4) in this process. - Source: PubMed
Publication date: 2026/05/14
Du GuoDing ZhaojunHou JianxunSu QiuyuLi QinhongXia XiaohuiYang Zhao - Glioblastoma (GBM) is the most common malignant brain tumor, and effective therapeutic strategies remain scarce. Therefore, the study aims to screen biomarkers to reveal the molecular mechanisms of cancer stem cells (CSCs) and disulfidptosis in GBM therapy. - Source: PubMed
Publication date: 2026/02/27
Tang DangRen ZhongkunGao BiboLong Jiang - Spondylolisthesis is a spinal disorder characterized by abnormal vertebral displacement, primarily affecting the lumbar region. Understanding the genetic factors underlying its progression is critical. - Source: PubMed
Publication date: 2026/02/04
Wang HuiNiu PengYang XiuLin XinLi JinquanWu GuangyinSun XiaotangHuang JianghuLin Feiyue - Peripheral neuropathies are common neurological disorders affecting sensory, autonomic, and motor nerves, with an estimated prevalence exceeding 2% in the general population. Typical symptoms include numbness and distal limb muscle weakness, resulting from somatosensory nerve damage. Here, we investigate the genetic architecture of mono- and polyneuropathies and their relationships with comorbid traits using data from FinnGen and the UK Biobank. Our genome-wide association study (GWAS) and meta-analysis identified 48 genome-wide significant (P < 5 × 10-8) independent loci and 66 fine-mapped credible sets. These included associations with genes involved in neurotransmitter signaling (HTR3A), immune function (HLA-DQB1, BCL11A), extracellular matrix remodeling (COL11A1, ADAMTS17, LOXL4), axon guidance and neural development (DCC, ETV1, NEGR1), and carpal tunnel syndrome (DIRC3). Public variant association data across cohorts, genetic correlation, and Mendelian randomization analyses supported shared genetic links of neuropathies with sleep problems, chronic pain, and psychiatric disorders. Together, our results highlight a strong polygenic basis for neuropathies and further confirm their genetic comorbid relationships with sleep, pain, psychiatric, and autoimmune traits. - Source: PubMed
Broberg MartinGen FinnKalso EijaOllila Hanna M