HSPA6 antibody
- Known as:
- HSPA6 (anti-)
- Catalog number:
- orb100154
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- HSPA6 antibody
Related genes to: HSPA6 antibody
- Gene:
- HSPA6 NIH gene
- Name:
- heat shock protein family A (Hsp70) member 6
- Previous symbol:
- -
- Synonyms:
- HSP70B'
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-26
- Date modifiied:
- 2015-11-19
Related products to: HSPA6 antibody
Related articles to: HSPA6 antibody
- Calcium oxalate (CaOx) nephrolithiasis is a recurrent urological disorder, and Randall's plaque (RP) of the renal papilla is widely accepted as an early site of stone nucleation. Although immune activation, epithelial injury, and extracellular matrix (ECM) remodeling have been reported in RP, the cell-type-specific transcriptional features of Epithelial Membrane Protein 1 (EMP1) in this tissue context remain undefined. - Source: PubMed
Publication date: 2026/06/10
Sardar NimraRaouf ShaziaBilal AsifIqbal SarfarazTanvir Fouzia - Estrogen receptor-positive breast cancer progression involves extensive cellular remodeling, yet the contribution of RNA-binding proteins to this process remains incompletely defined. Here, we constructed a single-cell transcriptomic atlas of 198,286 cells from 39 samples spanning normal tissue, primary tumors, and metastatic lesions. We identified stage-specific transcriptional and post-transcriptional reprogramming across different cell types. Several RBPs, including , , and , were progressively upregulated during malignant progression and associated with cytoskeletal remodeling, extracellular matrix interactions, and stress adaptation. Cell-cell communication analyses revealed metastasis-associated signaling programs involving TIMP1-MMP1 and TGFB1-COL7A1/MMP1, which were spatially enriched at tumor margins and invasive fronts. Functional perturbation experiments in ER breast cancer cells showed that TGF-β stimulation enhanced invasive behavior, whereas knockdown of MMP1 or COL7A1 attenuated epithelial-mesenchymal transition (EMT) marker expression and invasion. Together, our study delineates RBP-associated regulatory programs linking cellular state transitions to invasive signaling in ER breast cancer. - Source: PubMed
Publication date: 2026/05/28
Dong MingjieLi XinyuYang SongyuLi ShujuanLiu ZhengzhengPeng ChuoLi RongyaoLiang WeixinLi XiaBai Jing - Glioblastoma (GBM) is the most common and malignant primary brain tumor. Glioblastoma stem cells (GSCs) promote radioresistance and therapeutic failure, yet the underlying mechanisms remain unclear. Here, we show that heat shock protein HSPA6 promotes GSC radioresistance by enhancing GTP synthesis. HSPA6 is induced by irradiation and reduces GSC sensitivity to radiotherapy. HSPA6 interacts with and activates IMPDH2, a key rate-limiting enzyme in purine biosynthesis, thereby promoting GTP synthesis, reducing DNA damage, and enhancing radioresistance. Mechanistically, HSPA6 recruits ROCK2 to phosphorylate and activate IMPDH2 at S416. Pharmacological inhibition of HSPA6 and IMPDH2 combined with irradiation significantly improves survival in mice bearing GBM. Our study uncovers the crucial role of HSPA6/IMPDH2-mediated GTP synthesis in GSC radioresistance and suggests that targeting this axis may improve radiotherapy efficacy for GBM. - Source: PubMed
Publication date: 2026/06/02
Yang JunleiLin QiankunGu DanlingGao JianchengLiu YangYang KailinZhu ZheLu ChenfeiLi DaqiCi ShushengLin FanWang QianghuQian XuYou YongpingZhou QigangWang XiuxingLu MingZhang QianChen YunTao WeiweiZhang Junxia - The small-molecule pyridazinone derivative IMB5036 (IMB) exhibits significant cytotoxicity against multiple cancer cell lines, and KH-type splicing regulatory protein (KSRP) is confirmed as its direct binding partner. However, KSRP's functional role in neuroblastoma (NB) and the mechanism mediating IMB's antitumor effects remain unclear. This study analyzed public tumor databases and found KSRP expression negatively correlates with NB patients' median survival. Experiments showed IMB induces NB cell pyroptosis, immunogenic cell death (ICD, with calreticulin exposure), and cGAS-STING activation (to boost antitumor immunity), while CRISPR-Cas9-mediated KSRP knockout notably attenuates these effects. Transcriptome sequencing further confirmed KSRP mediates IMB's regulation of HSPA6/RSAD2. This study clarifies KSRP-dependent ICD drives NB antitumor immunity, providing a basis for KSRP-targeted NB immunotherapies. - Source: PubMed
Publication date: 2026/05/26
Dong YanqunXu YanfengZhang JunyiHong HanyuGao LingliWei HanruiZheng YijiaLv XingZheng Yan-BoYang JigangGong Jian-Hua - The mechanisms underlying gastric cancer (GC) progression, including recurrence and metastasis, remain unclear. Studies have reported that microRNAs and Men1 are closely associated with multiple tumors, including GC. Therefore, assessing the impact of Men1 on GC and investigating the underlying mechanisms are essential. - Source: PubMed
Publication date: 2026/05/06
Jiang Jin-XunZhang Shi-JieZhao KunZheng Kai-TianWang Shan-HuChen Tian-deWang Zhen