HSPA6 antibody
- Known as:
- HSPA6 (anti-)
- Catalog number:
- orb100154
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- HSPA6 antibody
Related genes to: HSPA6 antibody
- Gene:
- HSPA6 NIH gene
- Name:
- heat shock protein family A (Hsp70) member 6
- Previous symbol:
- -
- Synonyms:
- HSP70B'
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-26
- Date modifiied:
- 2015-11-19
Related products to: HSPA6 antibody
Related articles to: HSPA6 antibody
- Cervical cancer (CC) is a prevalent malignancy in women. RNA-binding motif single-stranded interacting protein 3 (RBMS3) acts as a tumor suppressor in many cancer types, but its role and underlying regulatory mechanisms in CC remain unclear. - Source: PubMed
Huang HuapingLi PingZhu LixiaWu YaweiLiu QinZhang Hong - Ovarian cancer (OC) persists as a highly fatal gynecologic tumor, underscoring the urgent need for dependable diagnostic markers and innovative therapeutic strategies. In this study, we identify Arachidonate 12-lipoxygenase (ALOX12) as a previously unrecognized ferroptosis-related tumor suppressive regulator with significant diagnostic and prognostic value in OC. By integrating Weighted Gene Co-expression Network Analysis (WGCNA), machine learning algorithms, and survival modeling, and validating our findings through in vitro and in vivo experiments, transcriptomic profiling, and biochemical assays, we systematically characterized the biological and mechanistic roles of ALOX12. Our analysis revealed that ALOX12 is markedly downregulated in OC tissues, with its low expression correlating with poor clinical outcomes. Functional experiments further demonstrated that ALOX12 suppresses OC cell proliferation, invasion, and migration, while promoting apoptosis and ferroptosis-associated lipid peroxidation. Mechanistically, transcriptome sequencing and protein assays pinpointed MAPK signaling as a key pathway modulated by ALOX12. Additionally, our experiments revealed that ALOX12 exerts its effects by regulating HSPA6 expression. Collectively, these findings highlight ALOX12 as a promising biomarker and potential therapeutic target, offering new insights into ferroptosis-associated signaling networks and their implications for improving the management of OC. - Source: PubMed
Publication date: 2026/07/24
Fang YihuaLiu XueningYang MengyaoZhang XiaohuiLi MinCao Yunxia - Adenoid cystic carcinoma is a rare salivary gland malignancy of the head and neck region characterized by perineural invasion, distant metastasis, and a lack of effective targeted therapies. The molecular mechanisms underlying its progression remain poorly understood. - Source: PubMed
Publication date: 2026/07/06
Zhao GangLi LixinZhang QiSu Yucheng - Perineural invasion (PNI) is a common pathological feature associated with poor prognosis of colorectal cancer (CRC). A better understanding of the mechanisms underlying PNI formation could help identify potential strategies to inhibit tumor progression. Here, we revealed an integral role of CD4+ T cells in the development and progression of PNI in CRC. Single-cell RNA sequencing, spatial transcriptomics, and multiplex immunohistochemistry profiling uncovered a distinct HSPA6+CD4+ T cell subset expressing T stress (Tstr) cell markers in CRC PNI tissues. Schwann cells (SCs) colocalized with the HSPA6+CD4+ Tstr cells in PNI, and functional studies showed that SCs promoted Tstr cell differentiation while Tstr cells enhanced SC migration. Interaction between SCs and CD4+ T cells activated the MAPK pathway in SCs and the JAK-STAT pathway in Tstr cells, and inhibition of MAPK and STAT signaling suppressed nerve invasion of CRC cells in vivo. Moreover, SCs in contact with tumor cells possessed the ability to recruit CD4+ T cells; tumor-derived TNF-α stimulated SCs to secrete CCL4, thereby recruiting CD4+ T cells toward SCs. The anti-TNF-α monoclonal antibody infliximab reversed the pro-invasive and pro-migratory effects of SCs on CRC cells and reduced intratumoral CD4+ Tstr cells, and the combination of infliximab with anti-PD-1 treatment produced a combinatorial tumor suppressive effect. Together, this study suggests that SCs near CRC tissues recruit CD4+ T cells and promote their conversion to CD4+ Tstr cells to establish an immunosuppressive microenvironment and simultaneously enhance the migration and tumor-promoting capabilities of SCs, thereby accelerating PNI development. - Source: PubMed
Publication date: 2026/07/23
Liu HuayuanDeng YiqiaoYang YiXue JunshuaiMaimaitiming NuersimanguliWang BingzhiXin YujingZhou JinxueLiu XiaomengGuo ChengyaoYang LangHuang ZhenZhou HaitaoCai JianqiangZhao Hong - The liver is a central regulator of metabolic and endocrine functions that support fetal growth and postnatal development. Prenatal stress can reprogram hepatic development in the offspring, potentially causing long-term changes in metabolism and production efficiency. However, the influence of prenatal stress on hepatic molecular function and resulting phenotypes in beef cattle remains poorly understood. Therefore, the objectives of this study were to evaluate phenotypic traits and liver tissue gene expression in Brahman heifer and bull calves from prenatal transportation stress (PNS) and control (Control) treatment groups. One group of pregnant Brahman cows were transported for a 2-h period every 20 (±5) d from 60 to 140 days of gestation. Another group of pregnant Brahman cows served as Control. Thirty-two calves, eight heifer and eight bull calves from the PNS and Control groups, respectively, were utilized. Calves were weighed at approximately 25 (±2) d of age. The following day, calves were euthanized, and liver tissues were harvested. Phenotypic traits evaluated include birth weight, harvest weight, liver weight, pen score, and liver weight:harvest weight. Interaction of sex and treatment did not explain substantial variation for any trait ( > 0.28). Sex influenced birth weight, harvest weight, liver weight ( < 0.05), and treatment influenced liver weight:harvest weight ( < 0.10). Linear regression coefficients of traits on calf age as a linear covariate were not different from 0 ( > 0.41). Controlling false discovery rate at 0.10, there were no differentially expressed genes for PNS relative to Control and 13 differentially expressed genes for male relative to female comparisons. No genes were found to be differentially expressed across all comparisons. It is possible that the few differences between sexes and treatments may be due to relatively small sample sizes or to an unknown adaptation mechanism to the stress prenatally induced by this young age. Heightening the severity of prenatal transportation stress through increased duration or frequency of transportation may result in more differentially expressed genes. - Source: PubMed
Publication date: 2026/07/06
Sebesta Sierra RBaker Emilie CCilkiz Kubra ZCardoso Rodolfo CHairgrove Thomas BLong Charles RRandel Ronald DWelsh Thomas HRiley David G