SEPT12 antibody
- Known as:
- SEPT12 (anti-)
- Catalog number:
- orb100244
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- SEPT12 antibody
Related genes to: SEPT12 antibody
- Gene:
- SEPTIN12 NIH gene
- Name:
- septin 12
- Previous symbol:
- SEPT12
- Synonyms:
- FLJ25410
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-11-13
- Date modifiied:
- 2019-04-04
Related products to: SEPT12 antibody
Related articles to: SEPT12 antibody
- To identify and functionally characterize the pig septin12 gene, including its expression pattern, subcellular localization, and interacting proteins, to explore its potential roles in male reproduction. - Source: PubMed
Publication date: 2026/04/02
Wang PeiWang XiaHuo HailongLi LuogangWen FeidiWang ShuyanZhang YongYunTurgong RenaguliHuo Jinlong - Reproductive efficiency is an important component of profitability and sustainability in beef cattle production, particularly in tropical environments where animals are routinely exposed to environmental stressors. This study aimed to identify environmentally sensitive SNPs associated with sexual precocity traits in Nellore cattle and characterize candidate genes and biological pathways regulating sexual precocity under variable environmental conditions. For this purpose, three sexual precocity indicators were analyzed; one in heifers (heifer early calving probability at 30 months, HC30), and two in young males (scrotal circumference at 365 days, SC365; age at puberty, APM). Reaction norm models were integrated with genome-wide association studies (GWASs) to identify genomic regions associated with both genetic potential (intercept) and environmental sensitivity (slope). - Source: PubMed
Publication date: 2026/01/21
da Silva Oliveira EduardaRojas de Oliveira HinayahMacedo Mota Lucio FlavioMulim Henrique AlbertoFerreira Campos Milena AparecidaBarbosa da Silva Neto JoãoBaldi Fernando - SEPT12, as a member of the septin gene family, is preferentially expressed in the adult male testis and plays an important role in the spermatogenesis and maturation of sperm. It is also essential for the maintenance of the structural integrity of the sperm tail. SEPT12 is closely related to sperm morphological abnormality, and its mutation leads to decreased fertility or infertility of males. This review presents an overview of the advances in and affords a prospect of the studies on the structure and biological functions of SEPT12 and the impact of its mutation on male fertility. - Source: PubMed
Chen Hai-XiaZhang JingMu Xiao-HuanTian Wen-Yan - Non-obstructive azoospermia (NOA) is a severe form of male infertility, affecting 10-20% of azoospermic men. Although some NOA genes have been identified, the genetic causes of spermatogenesis failure in NOA remain unclear. This study aimed to identify and characterize genes and mutations associated with NOA. - Source: PubMed
Publication date: 2025/04/27
Yao WenliangFu JingwenZhang DuanjunChen ShenghuiZhou YuliangJiang XianglongZheng XiaotingZhang MingliangWu Feihua - Infertility affects around 8%-12% of reproductive-aged couples and is a major health concern. Both genetic and environmental factors influence male infertility. is a crucial testis-specific gene essential for the final differentiation of male germ cells and is strongly linked to male infertility due to numerous detected mutations. The present study identified a novel mutation that causes male infertility. Immunofluorescence staining and transmission electron microscopy (TEM) analysis of T96I sperm revealed co-localization of SEPT12 and SEPT7 in the obliquely positioned annulus. In addition, the sperm carrying the T96I mutation demonstrated large nuclear vacuoles, irregular swelling, and decondensation of the acrosomal cap. The overexpression of SEPT12 T96I in NT2/D1 cells impaired the formation of SEPT7 filaments, emphasizing the significance of SEPT12 filaments for sperm morphology and function. Our results demonstrate the importance of in male infertility and offer valuable insights for future detection in infertile men. - Source: PubMed
Publication date: 2025/01/07
Chen Kuan-RuWang Han-YuKuo Yung-CheLo Yu-ChihKuo Pao-Lin