MATK antibody
- Known as:
- MATK (anti-)
- Catalog number:
- orb100284
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- MATK antibody
Related genes to: MATK antibody
- Gene:
- MATK NIH gene
- Name:
- megakaryocyte-associated tyrosine kinase
- Previous symbol:
- -
- Synonyms:
- HYLTK, CTK, HYL, Lsk, CHK, HHYLTK, DKFZp434N1212, MGC1708, MGC2101
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-22
- Date modifiied:
- 2016-07-26
Related products to: MATK antibody
Related articles to: MATK antibody
- Vasogenic cerebral edema is a severe complication of delayed thrombolysis for ischemic stroke, for which no pharmacological treatment exists. Anisodine hydrobromide (Ani), an alkaloid used clinically in China for vascular disorders, is investigated for its potential to mitigate this condition. Here we show that Ani treatment improves survival and neurological function in a mouse model of delayed rtPA-induced cerebral edema by preserving the integrity of the blood-brain barrier. Utilizing proteomics and microarray screening, we identify megakaryocyte-associated tyrosine kinase (Matk) as a direct target of Ani. We demonstrate that Ani binding stabilizes Matk, preventing its degradation and suppressing the activation of Src kinase. This inhibition consequently blocks the dual paracellular and transcellular leakage pathways that drive vasogenic edema. Our findings reveal the Matk-Src signaling axis as a therapeutic target and support Ani as a promising clinical candidate for preventing post-thrombolytic complications in stroke management. - Source: PubMed
Publication date: 2026/06/08
Guo SongLi An-QingChen Fan-KaiWeng Ding-ZhouWang ZhengYang ChongZhang Yu-JieZhang YiChang XinLiang Hong-BiaoLiu Jian - is one of the few genera in Crassulaceae that includes both dioecious and hermaphroditic species. However, previous studies have mainly relied on representative individuals or limited plastid fragments, which may not fully resolve evolutionary relationships within the genus, especially lineage divergence associated with sexual-system differentiation. - Source: PubMed
Publication date: 2026/05/11
Zang ErhuanZhu YandaMa DengxiuZou HongminZeng LingchaoShi LinchunLiu Jinxin - Balos, Köse & Sonay (Amaryllidaceae, sect. ) is described as a new species from southeastern Anatolia, Türkiye. The species is morphologically distinguished from its closest relatives-, subsp. , subsp. , and -by a unique combination of characters: blackish outer bulb tunics, semi-cylindrical solid leaves exceeding the inflorescence, an extremely long persistent two-valved spathe (4.5-28.0 cm), a lax hemispherical inflorescence (3-4 cm diam., 10-70 flowers), a goblet-shaped perigon with dentate inner tepals, exserted bicolored stamens (white at base and apex, purple in the middle), a reticulate-foveate ovary, and verrucate seed ornamentation with undulate anticlinal walls. Seed micromorphology examined by scanning electron microscopy (SEM) further supports species delimitation. Molecular phylogenetic analyses based on nuclear ITS and chloroplast matK sequences place within a well-supported clade containing and allied species, corresponding to the eastern Mediterranean lineage of sect. . ITS genetic distances between and its morphologically closest relatives range 0.0632, falling within the typical interspecific range for . The species is known from a single locality in Bozova district (Şanlıurfa) with fewer than 100 mature individuals and is assessed as Critically Endangered (CR) according to IUCN criteria. This discovery highlights southeastern Anatolia as an underexplored center of diversification and underscores the importance of integrative taxonomy for species delimitation within this taxonomically complex group. - Source: PubMed
Publication date: 2026/05/21
Balos Mehmet MarufKöse Yavuz BülentSonay VeyselTunç Fatmanur - CsMORF9.3 regulates chlorophyll biosynthesis, affecting the RNA editing efficiency of matK-445, rpoA-200, ndhD-674 and ndhD-1310, and it interacts with CsMORFs, CsPPRs and CsCHLD proteins. Leaf color is an important factor affecting tea quality as well as the growth and development. It has been reported that several genes and transcription factors participated in chlorophyll metabolism in tea plants (Camellia sinensis). However, the role of chloroplast RNA editing factors in chlorophyll biosynthesis in C. sinensis remains poorly understood. In this study, multiple dysregulated RNA editing sites in the chloroplast genome were identified from etiolation and albino tea cultivars. Multiple organellar RNA editing factor 9.3 (CsMORF9.3), a core RNA editing factor localized in the chloroplasts, was identified as a candidate regulator of leaf coloration. Antisense oligonucleotide (AsODN) and virus-induced gene silencing (VIGS) confirmed that suppressing CsMORF9.3 expression reduces chlorophyll content, downregulates genes involved in chlorophyll biosynthesis and chloroplast development, as well as disrupts chloroplast RNA editing. Protein-protein interaction assays confirmed that CsMORF9.3 could form both homodimers and heterodimers with itself or other MORF proteins through yeast two-hybrid (Y2H), luciferase complementation imaging (LCI) assays, and bimolecular fluorescence complementation (BiFC) assays. Moreover, CsMORF9.3 was found to interact with multiple PLS-type pentatricopeptide repeat (PPR) proteins, including CsCRR21, CsCRR28, CsOTP84, and CsLPA66, as well as with CsCHLD, a key subunit of magnesium chelatase in chlorophyll biosynthesis. Our study provides the protein interaction of CsMORF9.3, demonstrating its potential role in regulating RNA editing and chlorophyll biosynthesis in C. sinensis. These results broaden the understanding of the regulatory mechanisms of chlorophyll biosynthesis and provide new insights into the breeding of etiolation and albino tea plant germplasm. - Source: PubMed
Publication date: 2026/05/20
Zhang PinzhiZhang MengyuanLiu XufanMeng YangZhang PuyuMa ZhiqinXiao YaoGao Yuefang - (commonly known as kratom) is a tropical tree native to Southeast Asia, ethnobotanically used for pain relief and fatigue management. Kratom has gained popularity in Western countries for its dose-dependent stimulant and opioid-like effects, and its reported use in the self-treatment of opioid withdrawal. Kratom leaves accumulate over 50 monoterpene indole alkaloids (MIAs) and oxindole alkaloids that have pharmaceutical significance, to which many of these effects are attributed. In this study, we characterized eight kratom accessions originating from Central and Southern Thailand which exhibited phenotypic variation in leaf morphology, including differences in shape, margins, and vein coloration. To authenticate and evaluate genotypic variation among these accessions, we employed DNA barcoding using four loci: the , and three plastid barcodes including , and No polymorphisms were detected using and barcodes. However, sequence analyses revealed insertion-deletion polymorphisms in , and single nucleotide polymorphisms in both and , resolving intraspecific variation and separating the accessions into two distinct haplotypes. Targeted metabolite profiling was conducted using UPLC-MS to quantify 17 MIAs and oxindole alkaloids from both young and mature leaves across all kratom accessions. Mitragynine was the most predominant alkaloid in mature leaves, reaching up to 1.19% w/w of leaf dry mass, whereas juvenile leaves accumulated speciociliatine as the major alkaloid, at levels up to 1.14% w/w. Notably, strictosidine, the central precursor of MIA biosynthesis, was detected exclusively in juvenile leaves, which also exhibited significantly higher levels of upstream intermediates including corynantheidine, and iso-corynantheidine compared with mature leaves. In addition, juvenile leaves were dominated by 3 MIAs, whereas mature leaves accumulated higher levels of 3 MIAs. However, the relative distribution of 3 and 3 stereoisomers remained consistent across accessions. Under the conditions examined, leaf developmental stage exerted a greater influence on alkaloid composition than accession or haplotype variation. Despite visible distinction in leaf vein coloration, alkaloid profiles at maturity remained largely consistent across all accessions. The developmental chemotype patterns presented in this study provide a valuable framework for targeted breeding, metabolic engineering, and controlled cultivation strategies aimed at optimizing specific MIA profiles, particularly those of pharmacological interest. - Source: PubMed
Publication date: 2026/05/04
Ransden Katherine ERamachandria PavithraLaforest Larissa CKanumuri Siva Rama RajuSharma AbhisheakMcCurdy Christopher RNadakuduti Satya Swathi