PPIB antibody
- Known as:
- PPIB (anti-)
- Catalog number:
- orb100302
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- PPIB antibody
Related genes to: PPIB antibody
- Gene:
- PPIB NIH gene
- Name:
- peptidylprolyl isomerase B
- Previous symbol:
- -
- Synonyms:
- CYPB, OI9, PPIase, B, CYP-S1, SCYLP
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-25
- Date modifiied:
- 2019-04-23
Related products to: PPIB antibody
Related articles to: PPIB antibody
- Peptidyl-prolyl isomerase B (PPIB), a member of the peptidyl-prolyl cis-trans isomerase family, is well-documented to facilitate viral propagation by interactions with viral proteins. However, its regulatory roles in the replication of bovine ephemeral fever virus (BEFV) or vesicular stomatitis virus (VSV), as well as in host innate immune responses remain unexplored. In this study, we demonstrate that PPIB enhances the replication of BEFV and VSV and suppresses the host type I interferon (IFN-I) response. Mechanistically, PPIB interacts with phenazine biosynthesis-like domain-containing protein (PBLD), a positive regulator of innate immunity, and triggers its degradation via the ubiquitin-proteasome pathway. Further analyses showed that PPIB enhances the interaction between the E3 ubiquitin ligase March2 and PBLD, thereby facilitating PBLD ubiquitination and subsequent degradation. This PPIB-mediated, March2-dependent degradation of PBLD inhibits IFN-I production, ultimately enhancing viral replication. Collectively, our findings unveil an unrecognized role of PPIB in regulating IFN-I responses and viral replication through the PPIB-March2-PBLD signaling axis, providing novel insights for the development of broad-spectrum antiviral therapeutics. - Source: PubMed
Publication date: 2026/07/15
Zhu HongchaoWang XiaomengChu FengyunWang HongmeiHe HongbinHou Peili - Breast cancer (BC) remains a leading cause of cancer-related mortality worldwide. Cancer-associated fibroblasts (CAFs) is a central stromal component of the tumor microenvironment (TME), critically influence BC progression and therapeutic resistance. However, the association between CAF heterogeneity and patient prognosis or response to immunotherapy remains poorly characterized. Here, we aimed to develop a CAF-associated gene signature by integrating single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data to predict clinical outcomes and immunotherapeutic response in BC. - Source: PubMed
Wang QiChen JingZhang ShuyaoLiu YiXu LianTian LinRen JunqiSu ZhanhaiTang Zhengang - Horses are major domestic animals and cultural symbols that have accompanied humans for millennia. They underpin transport, agriculture, warfare and sport, and also provide a model for studying domestication, complex traits and adaptive evolution. Recent work in equine genomics has now generated a much richer picture of how these roles are grounded in the genome. This review brings together advances in several connected areas: the construction and refinement of reference assemblies; genomic reconstructions of origin, domestication and dispersal; global and regional patterns of genetic diversity; and the molecular basis of key traits such as athletic performance, coat colour, body size, environmental adaptation and inherited myopathies. The transition from EquCab1.0/2.0 to EquCab3.0 and a complete Y-chromosome sequence illustrates how long-read and Hi-C/T2T data improve genome completeness and the representation of complex regions. On this foundation, high-coverage resequencing of ancient and modern horses has clarified the geographical core of domestication in the Volga-Don region, the Bronze Age replacement of earlier domestic lineages and the long-term impact of human management on behaviour, conformation and mobility. Comparative analyses of mitochondrial DNA, Y-chromosomal haplotypes and autosomal runs of homozygosity further reveal a combination of diverse maternal lineages, highly constrained paternal lineages and breed-specific inbreeding histories. Against this background, studies of representative traits show how association signals, functional experiments and clinical evidence can be linked to practical tools for breeding and health management, for example through -guided performance profiling, -based altitude adaptation and molecular tests for , , and . We conclude by considering how telomere-to-telomere assemblies, pangenome resources, improved structural-variant detection and closer integration between population genomics and functional studies may support conservation, health surveillance and molecular breeding in diverse horse populations. - Source: PubMed
Publication date: 2026/06/17
Lu YingMa RuoshanWang BoWu JiaoChong YuqingGao ZhendongDeng Weidong - High-grade serous carcinoma of the ovary/fallopian tube (HGSC) is a remarkably heterogeneous tumor. The purpose of this study was to directly compare the reproducibility of transcriptomic profiles and biologically relevant molecular features across 2 spatial transcriptomics platforms-GeoMx Digital Spatial Profiler (GeoMx) and Visium Spatial Gene Expression (Visium)-using artificial intelligence (AI)-defined tumor regions associated with clinical outcome. - Source: PubMed
Publication date: 2026/05/15
Youssef OmarSelander LarsZheng ShuyuCsellar LillaHänninen SatuTang JingCarpén OlliLaury Anna Ray - Arteriovenous fistulas (AVFs) exhibit a high incidence of stenosis after maturation, which is a major cause of access failure in hemodialysis patients. However, its cellular heterogeneity and molecular mechanisms are not well clarified. For patients with post-maturation AVF stenosis (AVFS), we applied single-cell RNA sequencing on AVFS and matched non-stenotic vessels, followed by differential expression and pathway analyses to identify candidate cell types, genes and potential functional changes. Upstream transcription factors of the candidate genes were predicted using AnimalTFDB. The predicted molecular pathway was validated in vitro using HUVECs. Dual-luciferase assays tested transcription factor-gene interactions; qRT-PCR and Western blotting measured expression levels; immunofluorescence staining detected α-SMA; and wound healing assays assessed cell migration. Eight vascular cell types were identified, with endothelial cells showing the greatest proportional increase in AVFS. Differential expression analysis highlighted PPIB as the candidate gene, and enrichment analyses implicated endothelial-to-mesenchymal transition (EndMT). PPIB could promotes EndMT, as indicated by decreased VE-cadherin/CD31, increased α-SMA, and enhanced migration. Upstream transcription factor prediction identified YBX1 as a direct transcriptional regulator of PPIB, and dual-luciferase assays confirmed their interaction. YBX1 overexpression elevated PPIB levels and accelerated EndMT, whereas PPIB knockdown reversed these effects. This study reveals a novel YBX1–PPIB regulatory axis driving EndMT in endothelial cells, thereby contributing to post-maturation AVFS pathogenesis. These findings provide mechanistic insights and suggest potential therapeutic targets for preventing post-maturation AVFS. - Source: PubMed
Publication date: 2026/04/22
Chen LingWan ZimingGao XuejingChen ChaoGan Hua