AQP0 antibody
- Known as:
- AQP0 (anti-)
- Catalog number:
- orb100363
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- AQP0 antibody
Related genes to: AQP0 antibody
- Gene:
- MIP NIH gene
- Name:
- major intrinsic protein of lens fiber
- Previous symbol:
- -
- Synonyms:
- MP26, LIM1, AQP0
- Chromosome:
- 12q13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: AQP0 antibody
Related articles to: AQP0 antibody
- (PV) is a severe autoimmune blistering disease characterized by pathogenic autoantibodies primarily targeting desmoglein-3. B-cell depletion by rituximab (anti-CD20) is an effective first-line treatment for PV; however, relapses are frequently observed. Evidence suggests that PV is associated with immune dysregulation beyond the B-cell compartment. So far, existing studies have largely focused on selected immune components or populations, or specific clinical states such as active disease, remission, or immediate post-rituximab, leaving it unclear how prior rituximab treatment shapes the overall circulating immune landscape during active PV, including relapse. In this study, we performed high-dimensional immune profiling to characterize circulating immune-cell composition and cytokine/chemokine signatures using a 40-colour spectral flow cytometry panel and a 46-plex Luminex assay, respectively. We compared active PV patients with healthy controls and performed a subgroup analysis of rituximab-naive versus rituximab-experienced relapsed PV patients. High-dimensional immune profiling showed that active PV is associated with a redistribution of circulating immune cells, with increased monocytes and decreased lymphocytes and plasmacytoid dendritic cells, together with reduced frequencies of double-negative (CD4CD8) T cells and T follicular helper cells compared with healthy controls. When comparing rituximab-naive with rituximab-experienced PV patients, in rituximab-experienced patients, the cellular composition changes were confined to the B-cell compartment, showing a shift toward a naive-dominant B-cell subset distribution. In parallel, PV was characterized by elevated serum concentrations of CD40L, CCL11/eotaxin, G-CSF, IL-1RA, IL-7, CCL20/MIP-3α, PD-L1/B7-H1/CD274, PDGF-AB/BB, and CCL5/RANTES, while no differences were identified between rituximab-naive patients and rituximab-experienced relapsed PV patients. Correlation analysis revealed that prednisone dosage may increase the frequency of mature B cells, and levels of CCL11/eotaxin, and IL-7, while decreasing the frequency of plasmacytoid dendritic cells and T follicular helper cells. Together, these findings reveal a systemic immune signature of active PV involving changes in circulating monocyte, T-cell, and soluble immune compartments, whereas prior rituximab exposure in relapsed patients is associated with sustained remodelling confined to B-cell subset composition, without long-term restructuring of non-B-cell immune lineages. - Source: PubMed
Publication date: 2026/08/03
Strandmoe Anne-LiseBonasia Carlo GInrueangsri NanthichaAbdulahad Wayel HStrating Inge MMennega Kevin PBijma TheoDiercks Gilles F HBremer JeroenLaman Jon DHorváth BarbaraHeeringa Peter - G protein-coupled receptors (GPCRs) are one of the largest families of membrane proteins in insects, regulating vision, neural signal transduction, and various physiological behaviors. Megalopta genalis exhibits a unique facultatively eusocial lifestyle and possesses adaptations for nocturnal activity; however, its GPCR family has not yet been systematically characterized. In this study, we performed genome-wide identification, phylogenetic analysis, and expression profiling of GPCRs in M. genalis by integrating genomic annotation and transcriptomic analysis. The results showed that a total of 99 GPCRs were identified in the genome of M. genalis, which were classified into four major families. Here, we show that M. genalis has undergone lineage-specific GPCR repertoire remodeling, marked by the expansion of novel orphan receptors and the systematic loss of multiple receptor subtypes, such as the neuropeptide receptors MIP-R and NPFR. Moreover, opsins have formed a diverse array of combinations and non-GPCR odorant receptors have undergone significant expansion via tandem duplication. Together, these features may represent part of the molecular repertoire associated with the adaptation of M. genalis to a nocturnal lifestyle. Furthermore, transcriptomic analysis revealed distinct spatiotemporal expression divergence within each of the Mth/Mthl and Fz GPCR families, suggesting functional specialization across development and adult tissues. This study provides the first systematic identification and initial functional characterization of GPCRs in M. genalis, revealing an evolutionary pattern characterized by the coexistence of contraction and expansion within the GPCR family. These findings lay a foundation for further studies aimed at elucidating the roles of these GPCRs in regulating M. genalis physiology and behavior. - Source: PubMed
Publication date: 2026/08/06
Zhang MeiqianDeng XinyiGuo MengyiLi ChengjunLi Bin - Maximal inspiratory (MIP) and expiratory (MEP) pressures indicate respiratory muscle strength. Published reference equations typically cover limited age ranges, causing artificial shifts in predicted values during age transitions. Our aim was to develop continuous MIP and MEP reference equations from childhood to advanced age. - Source: PubMed
Publication date: 2026/08/14
Gochicoa-Rangel LauraHernández-Ruiz JuanaMoreno-Chavarría TakiSánchez-Santillán Rocío NayeliLeón-Gómez PabloCid-Juárez SilviaFlores-Valadez MarioAlvarado-Amador IrlandaCenteno-Saenz Gustavo IVargas Mario HRodríguez-Moreno LuisTorre-Bouscoulet LuisFernández-Plata RosarioMartínez-Briseño David - Recent advancements in wide-field mid-infrared photothermal (MIP) microscopy offer rapid chemical contrast for biological, biomedical, and polymer analysis at submicron resolution. Currently, the field of view (FOV), signal-to-noise ratio (SNR), and imaging speed are limited by mid-infrared pump fluence, non-uniform mid-infrared illumination, relatively small photothermal scattering change, and consequently the need for multiple camera frame averaging to achieve photothermal contrast. To correct non-uniform illumination, expand FOV, and improve SNR, flat-field correction, feature-based image stitching, and deep-learning image denoising are integrated within our previously developed wide-field quantum-cascade-laser MIP workflow. A feature-based stitching algorithm with flat-field correction combines individual small MIP frames into large composite mosaics, which is demonstrated on expanded MIP images of tuberculosis-infected lung tissue. Quantitatively, stitching delivered high-fidelity reconstructions, yielding structural similarity index measure (SSIM) and normalized cross-correlation (NCC) values >0.97 in overlaps. For denoising, a residual dense U-Net (RDUNet) is trained with high-frame-average data to predict high-SNR images from low-frame-average inputs. The method is applied to wide-field MIP images of polyethylene terephthalate (PET) microparticles. RDUNet boosted SSIM by >0.7 and peak SNR by >5 dB while predicting clean images of PET particles in less than 1 second. Overall, stitching of mosaics from multiple wide-field MIP images at low-frame numbers paves the way towards large-area, high-contrast MIP imaging, advancing chemical imaging towards high-throughput applications. - Source: PubMed
Raveendran Anooj ThayyilCael SupatchareePopp JuergenKrafft Christoph - Malaria remains a significant public health problem globally, with highest morbidity and mortality reported in sub Saharan Africa. In 2022, 12.7 million (36%) Malaria in Pregnancy (MiP) cases in Sub Saharan Africa and 27% were reported from East Africa. In Kenya, 4,080,441 malaria cases and 5% MiP cases reported. Busia County, Kenya, reported 341,886 malaria cases and 22% MiP cases. WHO recommends administering intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) to prevent MIP in malaria-endemic zones. The objective of the study was to determine proportion of pregnant women utilizing IPTp-SP 3 and describe factors influencing utilization of IPTp-SP 3. - Source: PubMed
Publication date: 2026/08/14
Angute Collins OmondiOlubulyera Stephen JoramOwiny MauriceOyugi ElvisMenya Diana