AQP0 antibody
- Known as:
- AQP0 (anti-)
- Catalog number:
- orb100363
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- AQP0 antibody
Related genes to: AQP0 antibody
- Gene:
- MIP NIH gene
- Name:
- major intrinsic protein of lens fiber
- Previous symbol:
- -
- Synonyms:
- MP26, LIM1, AQP0
- Chromosome:
- 12q13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: AQP0 antibody
Related articles to: AQP0 antibody
- Desiccation-tolerant mosses survive extreme water loss by activating efficient photoprotective mechanisms that prevent damage to the photosynthetic apparatus. The most resistant moss Syntrichia caninervis (S. caninervis) represents an important model for studying the molecular basis of dehydration resilience; however, the membrane and protein level processes, which enable rapid recovery of photosynthetic activity upon rehydration, remain insufficiently understood. In this work, we investigate the fluorescence (FL) dynamics of the photosynthetic apparatus of S. caninervis under three hydration states (hydrated, dehydrated and desiccated) in whole leaves using time-resolved FL spectroscopy. Time-resolved measurements with ~ 10 ps resolution were performed to resolve excitation dynamics in both photosystems I (PSI) and II (PSII). The complex FL datasets were analysed using the spectral decomposition approach. Dehydrated and desiccated samples exhibit substantially reduced FL intensity compared to hydrated moss in steady-state experiments, indicating efficient quenching of chlorophyll excitation upon drying. The time-resolved FL measurements revealed that excitation transfer rates and the nature of quenched states strongly depend on hydration level in S. caninervis. In the hydrated state, FL dynamics are consistent with functional photosystems in plants. Upon dehydration, non-photochemical quenching is activated in both PSII and PSI, with PSII quenching persisting even at low temperatures. We therefore conclude, that S. caninervis employs few hydration-dependent photoprotective regimes, including distinct quenching mechanisms at both photosystems. Our results suggest the presence of ultrafast quenching processes under severe dehydration, which are progressively relieved during rehydration and replaced by alternative mechanisms supporting the recovery of photosynthetic activity. - Source: PubMed
Publication date: 2026/07/10
Streckaite SimonaChmeliov JevgenijČirgelis ViliusFranckevičius MariusGolubewa LenaYin BenfengRutkauskas DanielisYang ChunhongValkunas LeonasZhang YuanmingRobert Bruno - In this study, cardiac myosin-binding protein-C (cMyBP-C) imprinted and nonimprinted poly-(2-hydroxyethyl methacrylate-N-methacryloxy-(L)-tryptophan) polymeric film-based surface plasmon resonance (SPR) sensors were prepared for the detection of cMyBP-C using the microcontact imprinting method. The surface characterization of cMyBP-C imprinted (MIP) and nonimprinted (NIP) SPR sensors was investigated using contact angle measurements and atomic force microscopy. Kinetic analyses were performed in the concentration range of 0.05-300 ng/mL, and the limits of detection and quantification were calculated as 0.019 and 0.064 ng/mL, respectively. Equilibrium, adsorption, and desorption cycles were completed for 10 min in all of the kinetic analyses. The selectivity studies of MIP SPR and NIP SPR sensors were performed using the template molecule cMyBP-C with competing molecules creatine kinase-MB (CK-MB) and cardiac troponin T (cTnT). The relative selectivity coefficients of the MIP SPR sensor for cMyBP-C/cTnT and cMyBP-C/CK-MB were found to be 3.85 and 12.64 times, respectively. The applicability of the MIP SPR sensor was determined using solutions prepared in artificial plasma samples, both in the SPR system and by enzyme-linked immunosorbent assay (ELISA). - Source: PubMed
Publication date: 2026/06/25
Korkmaz MertDenizli AdilÇimen Duygu - Wide-field mid-infrared photothermal (MIP) imaging offers rapid label-free chemical contrast for biomedical and polymer analysis. Its field of view (FOV) depends on the mid-infrared pump power of infrared lasers. Here, a wide-field MIP microscope is presented using up to 150 nJ pulse energies of a free-electron laser (FEL) as the pump source to achieve a larger FOV compared to a quantum cascade laser (QCL) excitation with typically 1 nJ pulses. Both implementations use counter-propagating beam paths with a microsecond pulsed 450 nm LED as the probe source and a CMOS camera that records images using a virtual lock-in detection scheme. FEL's higher pulse power expands the FOV by approximately a factor of 20, enabling submicron-resolution wide-field MIP imaging of polystyrene beads, single cells, and a murine brain tissue section. QCL systems with less intense pump pulses achieve only 45 μm FOV for samples including polystyrene beads, -infected fixed tissue sections, and laryngeal cancer cryosections. IR spectra are reconstructed by tuning FEL and QCL wavelengths and collecting a series of wide-field images. We discuss current challenges and further improvements to implement high-power mid-IR pump lasers and shorter pulse probe sources for wide-field MIP imaging with even larger FOVs in the context of biomedical diagnostics and microplastic screening. - Source: PubMed
Publication date: 2026/06/23
Thayyil-Raveendran AnoojAdak SubhamShydliukh ArtemRedinger NataljaHauptmann MatthiasSchaible Ulrich EMühlig AnnaKlopf J MichaelGuntinas-Lichius OrlandoPopp JürgenKrafft Christoph - Rapid and selective detection of viral pathogens is essential for effective disease surveillance and outbreak control. To meet this demand, thermo-responsive epitope-imprinted nanogels were integrated into a quartz crystal microbalance (QCM) platform for the selective detection of Hepatitis A virus (HAV) in real samples. Two HAV-derived epitopes (Epitope 2 and Epitope 3), identified by in-silico analysis, were employed as templates for the solid-phase synthesis of molecularly imprinted polymer nanogels (MIP-NGs). Successful nanogel formation was confirmed by Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering, and electrophoretic light scattering. The binding affinities of the imprinted nanogels were comparatively evaluated using surface plasmon resonance, yielding dissociation constants (K) of 2.49 × 10 M and 5.07 × 10 M for Epitope-2 MIP-NGs and Epitope-3 MIP-NGs, respectively. Based on their superior affinity, Epitope-3 MIP-NGs were selected as recognition elements and immobilized onto the QCM sensor surface for mass-based virus detection. Two immobilization strategies were investigated: drop-casting and electrochemical deposition via cyclic voltammetry in the presence of o-aminophenol and graphene quantum dots. Sensor surface formation was verified by atomic force microscopy and contact angle measurements. HAV detection was performed at 38 °C, under conditions where nanogel collapse supports binding via epitope-specific cavities. Real-time QCM measurements revealed concentration-dependent frequency shifts corresponding to HAV binding, achieving a detection limit of 1.05 pM over a working concentration range of 1.33-85 pM. Selectivity was assessed using non-imprinted polymer nanogels yielding an imprinting factor of 1.9, while specificity was confirmed against other pathogenic viruses. Finally, successful HAV detection in human serum demonstrated the applicability of the sensing platform in complex biological matrices. - Source: PubMed
Publication date: 2026/06/27
Sehit EkinMarquant RodrigueHaupt KarstenAltintas Zeynep - The management of geriatric patients with urological cancers is becoming increasingly important due to rising life expectancy and the growing incidence of such diseases. However, treatment decisions are often based primarily on chronological age or clinical guidelines, whilst insufficient consideration is given to the functional reserve of older patients. Geriatric patients exhibit specific physiological changes such as impaired renal or liver function, sarcopenia, multimorbidity, polypharmacy, malnutrition and cognitive impairments, which increase the risk of postoperative complications, functional decline, delirium, falls and the need for care. Standard therapies can therefore lead to significant functional limitations despite their oncological benefits. The aim of modern uro-oncological treatment is not only to prolong life but, in particular, to preserve autonomy, mobility and quality of life. For the purpose of individualised treatment planning, current guidelines recommend a stepwise geriatric assessment. This begins with screening using the G8 and mini-COG©, followed by a simplified geriatric assessment or a comprehensive geriatric assessment (CGA) if any abnormalities are detected. Classifying patients as fit, vulnerable or frail enables risk-adapted treatment decisions and targeted geriatric interventions. This can improve functional reserves, reduce complications and potentially avoid the need for long-term care. - Source: PubMed
Publication date: 2026/07/09
Fiebig ChristianManseck AndreasStein JoachimPiotrowski AlexanderFröhner MichaelUmbehr MartinButea-Bocu MariusWiedemann Andreas