RISC antibody
- Known as:
- RISC (anti-)
- Catalog number:
- orb100392
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- RISC antibody
Related genes to: RISC antibody
- Gene:
- SCPEP1 NIH gene
- Name:
- serine carboxypeptidase 1
- Previous symbol:
- -
- Synonyms:
- RISC
- Chromosome:
- 17q22
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-02
- Date modifiied:
- 2012-09-20
Related products to: RISC antibody
Related articles to: RISC antibody
- Adipogenesis from mouse embryonic stem cells (mESCs) offers a tractable model for dissecting early adipocyte commitment, yet the mechanisms coordinating this transition across multiple biological layers remain incompletely understood. Here we present the first simultaneous five-layer multi-omics characterization of mESC-derived adipocyte differentiation, integrating transcriptomics, proteomics, secretomics, lipidomics, and metabolomics from matched adipogenic (Pos) and non-differentiating (Neg) cell populations at day 30. Applying Multi-Omics Factor Analysis (MOFA+), we identified a dominant shared latent axis that perfectly segregated Pos from Neg cells across all five views. Layer-specific functional enrichment converged on two principal biological axes: ECM remodeling - encompassing collagens, laminins, thrombospondins, and lysyl oxidases - and lipid metabolic reprogramming, with phospholipid and glycerolipid metabolic processes dominating the lipidomics/metabolomics layer. Ensemble Machine Learning Feature Ranking (EMFR) identified a secreted factor (Scpep1; importance score 0.90) as the top-ranked discriminatory feature. Network analysis revealed indirect ECM-lipid connectivity mediated by four bridging nodes (Plod1, Thbs2, Plg, Pmp22) through a hub subnetwork of phospholipid-metabolizing enzymes. Targeted qPCR validation of six candidate regulators (Itga5, Igfbp6, Pik3cg, Lpl, Acer3, Sirt1) confirmed RNA-seq concordance. These findings establish convergent ECM remodeling and lipid metabolic reprogramming as central axes of adipocyte identity acquisition from mESCs. - Source: PubMed
Publication date: 2026/06/02
Al-Sayegh MKhalili MAlzaabi MSultana MAli LAli MEl-Hadidi M - Transcriptome-wide association study (TWAS) contributes to discovering novel susceptibility genes related to diseases. Single-cell RNA sequencing (scRNA-seq) has been extensively applied to characterize cellular heterogeneity in various biological and pathological conditions. However, few studies have integrated TWAS and scRNA-seq to decode the pathogenesis of myasthenia gravis (MG) at cellular resolution. - Source: PubMed
Publication date: 2026/05/01
Li ShuangZhang YifanHou ChenluChang Ting - Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal interstitial lung disease marked by progressive extracellular matrix accumulation and irreversible lung architecture remodeling. Oxidative stress (OS) plays a crucial role in IPF pathogenesis, yet its role across distinct cellular compartments and tissue microenvironments remains incompletely characterized. - Source: PubMed
Publication date: 2025/12/08
Zhou XiangLu TongXu RanWang ChenghaoChen SimiaoChen JingChang XiaoyanLi MeifengShi JiaxinXu ChengyuZhao YupengPeng BoZhao JiayingZhang Linyou - - Source: PubMed
- Myocardial infarction (MI) is an ischaemic cardiovascular disease associated with increased morbidity and mortality. Previous studies have suggested that serine carboxypeptidase 1 (Scpep1) is involved in vascular diseases; however, its role in cardiac diseases remains unclear. This study aims to explore the role of Scpep1 in regulating cardiac homeostasis during MI. - Source: PubMed
Chen GuilinGan JingWu FanZhou ZengxianDuan ZikunZhang KeWang SongxueJin HuaLi YulinZhang ChiLin Zhuofeng