FLI1 antibody
- Known as:
- FLI1 (anti-)
- Catalog number:
- orb100425
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- FLI1 antibody
Related genes to: FLI1 antibody
- Gene:
- FLI1 NIH gene
- Name:
- Fli-1 proto-oncogene, ETS transcription factor
- Previous symbol:
- -
- Synonyms:
- SIC-1, EWSR2
- Chromosome:
- 11q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-05
- Date modifiied:
- 2019-04-23
- Gene:
- SENCR NIH gene
- Name:
- smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA
- Previous symbol:
- FLI1-AS1
- Synonyms:
- -
- Chromosome:
- 11q24.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2012-06-30
- Date modifiied:
- 2018-09-07
Related products to: FLI1 antibody
Related articles to: FLI1 antibody
- Super enhancer-lncRNA smooth muscle and endothelial cell-enriched migration/differentiation-associated lncRNA (SENCR) were highly overexpressed in cisplatin-resistant A549/DDP cells, while the mechanism was unclear. - Source: PubMed
Publication date: 2022/05/02
Shen QiangZhou HuixinZhang MeijuanWu RuihaoWang LiangxingWang YuminChen Jie - This report presents two families with interstitial 11q24.2q24.3 deletion, associated with malformations, hematologic features, and typical facial dysmorphism, observed in Jacobsen syndrome (JS), except for intellectual disability (ID). The smallest 700 Kb deletion contains only two genes: FLI1 and ETS1, and a long noncoding RNA, SENCR, narrowing the minimal critical region for some features of JS. Consistent with recent literature, it adds supplemental data to confirm the crucial role of FLI1 and ETS1 in JS, namely FLI1 in thrombocytopenia and ETS1 in cardiopathy and immune deficiency. It also supports that combined ETS1 and FLI1 haploinsufficiency explains dysmorphic features, notably ears, and nose anomalies. Moreover, it raises the possibility that SENCR, a long noncoding RNA, could be responsible for limb defects, because of its early role in endothelial cell commitment and function. Considering ID and autism spectrum disorder, which are some of the main features of JS, a participation of ETS1, FLI1, or SENCR cannot be excluded. But, considering the normal neurodevelopment of our patients, their role would be either minor or with an important variability in penetrance. Furthermore, according to literature, ARHGAP32 and KIRREL3 seem to be the strongest candidate genes in the 11q24 region for other Jacobsen patients. - Source: PubMed
Publication date: 2019/03/19
Conrad SolèneDemurger FlorenceMoradkhani KamranPichon OlivierLe Caignec CédricPascal CécileThomas CarolineBayart SophiePerlat AntoinetteDubourg ChristèleJaillard SylvieNizon Mathilde - Despite the increasing importance of long noncoding RNA in physiology and disease, their role in endothelial biology remains poorly understood. Growing evidence has highlighted them to be essential regulators of human embryonic stem cell differentiation. SENCR, a vascular-enriched long noncoding RNA, overlaps the Friend Leukemia Integration virus 1 (FLI1) gene, a regulator of endothelial development. Therefore, we wanted to test the hypothesis that SENCR may contribute to mesodermal and endothelial commitment as well as in endothelial function. We thus developed new differentiation protocols allowing generation of endothelial cells from human embryonic stem cells using both directed and hemogenic routes. The expression of SENCR was markedly regulated during endothelial commitment using both protocols. SENCR did not control the pluripotency of pluripotent cells; however its overexpression significantly potentiated early mesodermal and endothelial commitment. In human umbilical endothelial cell (HUVEC), SENCR induced proliferation, migration, and angiogenesis. SENCR expression was altered in vascular tissue and cells derived from patients with critical limb ischemia and premature coronary artery disease compared to controls. Here, we showed that SENCR contributes to the regulation of endothelial differentiation from pluripotent cells and controls the angiogenic capacity of HUVEC. These data give novel insight into the regulatory processes involved in endothelial development and function. - Source: PubMed
Publication date: 2016/02/22
Boulberdaa MouniaScott ElizabethBallantyne MargaretGarcia RaquelDescamps BettyAngelini Gianni DBrittan MairiHunter AmandaMcBride MartinMcClure JohnMiano Joseph MEmanueli CostanzaMills Nicholas LMountford Joanne CBaker Andrew H - Long noncoding RNAs (lncRNAs) represent a rapidly growing class of RNA genes with functions related primarily to transcriptional and post-transcriptional control of gene expression. There is a paucity of information about lncRNA expression and function in human vascular cells. Thus, we set out to identify novel lncRNA genes in human vascular smooth muscle cells and to gain insight into their role in the control of smooth muscle cell phenotypes. - Source: PubMed
Publication date: 2014/02/27
Bell Robert DLong XiaochunLin MingyanBergmann Jan HNanda VivekCowan Sarah LZhou QianHan YuSpector David LZheng DeyouMiano Joseph M