POC5 antibody
- Known as:
- POC5 (anti-)
- Catalog number:
- orb100447
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- POC5 antibody
Related genes to: POC5 antibody
- Gene:
- POC5 NIH gene
- Name:
- POC5 centriolar protein
- Previous symbol:
- C5orf37
- Synonyms:
- FLJ35779, MGC120442, MGC120443, MGC120444, hPOC5
- Chromosome:
- 5q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-02-06
- Date modifiied:
- 2013-08-05
Related products to: POC5 antibody
Related articles to: POC5 antibody
- The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and characterized 78 detailed cell types in the macaque AIC, revealing the diversity and specialization of this region in cell type, connectivity profile, signal-processing strategy and metabolic characteristics. Among these, we identified two transcriptomically and morphoelectrically defined von Economo neuron (VEN) subtypes, DSG2-expressing VEN-L and POC5-expressing VEN-S, transcriptomically relating to extratelencephalic and corticothalamic projection neurons, respectively. We also uncovered a previously underappreciated signal-processing strategy by VENs, whereby the geometry of the dendrite-originating axon reshapes action potential dynamics and enhances somatic responsiveness to deep-layer synaptic inputs. Our multimodal atlas establishes a molecular and functional framework for investigating the circuit principles underlying cognitive processes in the primate AIC. - Source: PubMed
Publication date: 2026/07/02
Liu Rui-FengHuang MengyaoShen YuhuiShao MingtingJing JunzhanXu NanaTang LeiLiu BiaodiShi JianmingChen FanruiHao Zhao-ZheJiang XiaolongLiu Sheng - Adolescent idiopathic scoliosis (AIS) is a multifactorial spinal deformity with poorly understood molecular mechanisms. This study investigates the role of the centrosomal protein POC5 in AIS pathogenesis using in vitro cellular systems and in vivo vertebrate models. POC5 mutations were found to disrupt centrosomal localization, impair ciliogenesis, alter cell-cycle progression, and reduce osteogenic differentiation. Functional analyses in zebrafish and mouse models revealed spinal deformities, retinal abnormalities, and multisystem defects consistent with ciliopathy-related phenotypes. These findings support a model in which POC5-dependent dysfunction contributes to AIS through impaired mechano-transduction and altered skeletal development. - Source: PubMed
Behzadi PardisHassan AmaniMathieu HélènePatten KessenParent StefanMoldovan Florina - This study investigated the antifungal performance of copper-based antimicrobial coatings developed by Gencoa Ltd., previously validated against bacterial ESKAPE pathogens, alongside newly formulated titanium oxide coatings, against key agricultural fungal pathogens: Alternaria alternata, Botrytis cinerea, Cladosporium cucumerinum, and Fusarium oxysporum. Testing was conducted both in vitro and in field trials within an actively used polytunnel. - Source: PubMed
Kubala AntonKillen PatriciaBoyle OisinBellido-Gonzalez VíctorSgrilli TommasoMcLean Samantha - Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. This study aimed to identify key genes involved in HCC development and elucidate their molecular mechanisms, with a particular focus on mitochondrial function and apoptosis. - Source: PubMed
Publication date: 2025/12/30
Shi HuihuiChen LeiHuang JuanLin XuejingHuang LeiTang MinLu KaiWang WenchaoZhu Maoling - Centrioles undergo marked transformations during spermatogenesis that are essential for sperm motility and male fertility. Despite their importance, the molecular mechanisms and ultrastructural dynamics underlying these transformations remain largely unknown. Here, we apply ultrastructure expansion microscopy and reveal previously unrecognized centriolar architectural changes in mouse male germ cells, including geometry switching between the two centrioles and stage-specific removal of distal tip proteins such as centrin and SFI1. We further identify the centrin-POC5 inner scaffold as a key structure selectively augmented at the distal centriole, which directly forms and anchors the flagellum. Functional analyses of knockout mice demonstrate that this inner scaffold is essential for distal centriole integrity and flagellar assembly in spermatids but dispensable in somatic cells and spermatocytes. Our findings provide a spatiotemporal molecular atlas of centriole remodeling during spermatogenesis and uncover the critical physiological role of the centriolar centrin-POC5 inner scaffold in mammalian reproduction. - Source: PubMed
Publication date: 2025/12/03
Takeda YutakaKajikawa ErikoWang JingwenIshida MoriéAlsheimer ManfredShibuya Hiroki