POC5 antibody
- Known as:
- POC5 (anti-)
- Catalog number:
- orb100447
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- POC5 antibody
Related genes to: POC5 antibody
- Gene:
- POC5 NIH gene
- Name:
- POC5 centriolar protein
- Previous symbol:
- C5orf37
- Synonyms:
- FLJ35779, MGC120442, MGC120443, MGC120444, hPOC5
- Chromosome:
- 5q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-02-06
- Date modifiied:
- 2013-08-05
Related products to: POC5 antibody
Related articles to: POC5 antibody
- Centrosomes and primary cilia regulate cellular processes, including microtubule organization and lineage-specific differentiation. POC5, a core component of the centriolar inner scaffold, has been linked to syndromic ciliopathies, yet its role in adipose biology remains unclear. This study investigates the impact of POC5 deficiency on ciliary organization, cellular senescence, adipogenesis, and insulin signaling. To this end, we analyzed primary dermal fibroblasts from a patient carrying a novel homozygous p.(Gln206Ter) POC5 variant and performed mechanistic evaluations in human adipose stem cells (ASCs) with CRISPR-Cas9-mediated POC5 knockout. Centriolar architecture was examined using Ultrastructure Expansion Microscopy (U-ExM), and cellular phenotypes were assessed through proliferation, senescence, and signaling analyses. POC5-deficient fibroblasts showed marked disruption of centriolar architecture, including absent or abnormal primary cilia and supernumerary centrioles. These defects were associated with a 35% decrease in proliferation and a premature senescence, evidenced by increased SA-β-gal activity and upregulation of p-p53, p16, and p21. Moreover, insulin signaling was impaired, with reduced phosphorylation of IRβ, AKT, and ERK1/2. These phenotypes were recapitulated in POC5-KO ASCs, which additionally exhibited a near complete block of adipogenic differentiation, associated with downregulation of PPARγ, C/EBPα, and SREBP1c. Overall, POC5 deficiency promotes insulin resistance and premature senescence, and impaired adipogenesis. These findings identify POC5-related disease as a centrosomal metabolic disorder and highlight the importance of centriolar integrity in systemic energy homeostasis, supporting the need for metabolic monitoring in individuals with POC5 pathogenic variants. - Source: PubMed
Pistorio ValeriaVatier CamilleCapel ÉmilieBeaupère CarineAuclair MartineSteunou VirginieMorichon RomainJoubert MichaelVigouroux CorinneGautheron JérémieJéru Isabelle - The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and characterized 78 detailed cell types in the macaque AIC, revealing the diversity and specialization of this region in cell type, connectivity profile, signal-processing strategy and metabolic characteristics. Among these, we identified two transcriptomically and morphoelectrically defined von Economo neuron (VEN) subtypes, DSG2-expressing VEN-L and POC5-expressing VEN-S, transcriptomically relating to extratelencephalic and corticothalamic projection neurons, respectively. We also uncovered a previously underappreciated signal-processing strategy by VENs, whereby the geometry of the dendrite-originating axon reshapes action potential dynamics and enhances somatic responsiveness to deep-layer synaptic inputs. Our multimodal atlas establishes a molecular and functional framework for investigating the circuit principles underlying cognitive processes in the primate AIC. - Source: PubMed
Publication date: 2026/07/02
Liu Rui-FengHuang MengyaoShen YuhuiShao MingtingJing JunzhanXu NanaTang LeiLiu BiaodiShi JianmingChen FanruiHao Zhao-ZheJiang XiaolongLiu Sheng - Adolescent idiopathic scoliosis (AIS) is a multifactorial spinal deformity with poorly understood molecular mechanisms. This study investigates the role of the centrosomal protein POC5 in AIS pathogenesis using in vitro cellular systems and in vivo vertebrate models. POC5 mutations were found to disrupt centrosomal localization, impair ciliogenesis, alter cell-cycle progression, and reduce osteogenic differentiation. Functional analyses in zebrafish and mouse models revealed spinal deformities, retinal abnormalities, and multisystem defects consistent with ciliopathy-related phenotypes. These findings support a model in which POC5-dependent dysfunction contributes to AIS through impaired mechano-transduction and altered skeletal development. - Source: PubMed
Behzadi PardisHassan AmaniMathieu HélènePatten KessenParent StefanMoldovan Florina - This study investigated the antifungal performance of copper-based antimicrobial coatings developed by Gencoa Ltd., previously validated against bacterial ESKAPE pathogens, alongside newly formulated titanium oxide coatings, against key agricultural fungal pathogens: Alternaria alternata, Botrytis cinerea, Cladosporium cucumerinum, and Fusarium oxysporum. Testing was conducted both in vitro and in field trials within an actively used polytunnel. - Source: PubMed
Kubala AntonKillen PatriciaBoyle OisinBellido-Gonzalez VíctorSgrilli TommasoMcLean Samantha - Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. This study aimed to identify key genes involved in HCC development and elucidate their molecular mechanisms, with a particular focus on mitochondrial function and apoptosis. - Source: PubMed
Publication date: 2025/12/30
Shi HuihuiChen LeiHuang JuanLin XuejingHuang LeiTang MinLu KaiWang WenchaoZhu Maoling