PAI1 antibody
- Known as:
- PAI1 (anti-)
- Catalog number:
- orb100547
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- PAI1 antibody
Related genes to: PAI1 antibody
- Gene:
- SERPINE1 NIH gene
- Name:
- serpin family E member 1
- Previous symbol:
- PLANH1, PAI1
- Synonyms:
- PAI
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: PAI1 antibody
Related articles to: PAI1 antibody
- Alternative polyadenylation (APA) and N6-methyladenosine (m6A) methylation are critical post-transcriptional regulators in cancer, yet their synergistic role in gastric cancer (GC) remains poorly understood. By integrating RNA-seq and MeRIP-seq data from paired GC tumor and adjacent normal tissues, we identified 9769 distinct APA events and 3117 differentially methylated sites. Concurrent 3'UTR length and methylation alterations were observed in 165 genes. Among these, SERPINE1 emerged as an independent prognostic factor; its high expression correlated with advanced TNM stages and poor survival across multiple independent cohorts. Moreover, elevated plasma SERPINE1 protein levels in an in-house cohort of 263 GC patients were significantly associated with worse overall and disease-specific survival. Mechanistically, the APA factor CSTF2 and the m6A reader IGF2BP1 were found to physically interact and cooperatively regulate SERPINE1 3'UTR selection. Silencing either factor shifted expression toward the long 3'UTR isoform and reduced SERPINE1 protein levels. Functional assays further confirmed that the short SERPINE1 isoform promotes GC cell proliferation, migration, and invasion more potently than the long isoform. Collectively, this study reveals that CSTF2 and IGF2BP1 synergistically drive SERPINE1 3'UTR shortening to enhance GC malignancy, highlighting SERPINE1 as a promising prognostic biomarker and potential therapeutic target. - Source: PubMed
Publication date: 2026/07/20
Wu ZhuoyiXu RuyunFang JuLiu BingZhang CaoZhang ShangxinNi Jing - Articular cartilage degeneration can lead to a progressive loss of joint function and, eventually, total joint failure. The use of mesenchymal stem cells (MSCs) for cartilage regeneration has proven effective; however, the difficulty of their clinical application has prompted research into other strategies, such as using MSC secretome instead of cells themselves. Our aim was to generate a culture system to obtain large amounts of MSC secretome with a controlled and known composition and the potential to induce articular cartilage regeneration. - Source: PubMed
Publication date: 2026/07/18
Bravo-Baranda LucíaMilián LaraSancho-Tello MaríaLlop-Miguel MauroMonleón-Guinot IreneMartínez-Ramos CristinaMorales-Tatay José ManuelMínguez-Rey María FeMata Manuel - This narrative review synthesizes current evidence on the role of SERPINE1/PAI-1 in acute respiratory distress syndrome (ARDS), with particular emphasis on inflammation-coagulation-fibrinolysis crosstalk. - Source: PubMed
Publication date: 2026/07/18
Gao NanYang SongZhang Wei-JianLu Hao-TianZhang Zheng-NanQian Yi-XinZhang Guo-Qiang - Abdominal symptoms are increasingly reported in invasive meningococcal disease (IMD), but the underlying mechanisms remain unclear. We aimed to explore the pathophysiology of these presentations using an animal model. - Source: PubMed
Publication date: 2026/07/17
Taha Muhamed-KheirOliveira DamienGros MarionAouiti-Trabelsi MyriamDeghmane Ala-Eddine - Peritoneal metastasis (PM) in colorectal cancer (CRC) is characterized by a highly immunosuppressive microenvironment and poor clinical outcomes, which are further exacerbated by elevated SERPINE1 (PAI-1) expression and the restrictive peritoneal-plasma barrier. To overcome these multifactorial challenges, we engineered a cobalt-based, redox-responsive smart hydrogel system (CoGel@TBB) for the spatiotemporal co-delivery of the PAI-1 inhibitor TBB and cobalt nanoparticles directly to the peritoneal cavity. Upon adhesion to the tumor surface, the hydrogel rapidly releases TBB to inhibit PAI-1, effectively remodeling the fibrotic stroma and enhancing tumor tissue permeability. Concurrently, the sustained release of cobalt ions catalyzes endogenous hydrogen peroxide into highly cytotoxic reactive oxygen species (ROS), triggering tumor cell pyroptosis and the subsequent release of mitochondrial DNA (mtDNA). Crucially, the released cobalt ions also function as STING agonists, synergizing with the mtDNA to robustly activate the cGAS-STING signaling pathway. Both in vitro and in vivo evaluations demonstrated that CoGel@TBB significantly augments dendritic cell maturation and CD8 T cell infiltration, successfully reversing the immunosuppressive landscape. Consequently, this localized, multi-strategy delivery platform achieved remarkable tumor suppression and extended survival in murine models of CRC peritoneal metastasis, offering a highly promising clinical paradigm for amplifying anti-tumor immunity. - Source: PubMed
Publication date: 2026/07/15
Zhang Lin-ZhuSi Liang-WeiXu HuiXiong FeiQin JuanZhu Hai-Dong