RPL19 antibody
- Known as:
- RPL19 (anti-)
- Catalog number:
- orb100548
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- RPL19 antibody
Related genes to: RPL19 antibody
- Gene:
- RPL19 NIH gene
- Name:
- ribosomal protein L19
- Previous symbol:
- -
- Synonyms:
- FLJ27452, MGC71997, DKFZp779D216, L19
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-29
- Date modifiied:
- 2019-04-23
Related products to: RPL19 antibody
Related articles to: RPL19 antibody
- Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract, characterized by immune dysregulation, genetic susceptibility, and environmental factors such as diet and psychosocial stress. The etiology of UC is complex, involving multiple interrelated factors that drive its pathogenesis and clinical progression. - Source: PubMed
Shi LihaoJin GuiyuanGao XizhuangChen YunZhao QianLin JianZhou Guangxi - This study aims to investigate the clinical efficacy and underlying mechanism of Huoxue Tongbi Formula in treating patients with steroid-induced osteonecrosis of the femoral head(SONFH) with meridian blockage syndrome. A total of 40 patients with SONFH and meridian blockage syndrome were retrospectively enrolled. Demographic data, clinical efficacy scores(pain and hip joint function), Harris scores, hip joint range of motion, imaging indices(ARCO stage, BUCMXE, bone marrow edema, and joint effusion), symptom/syndrome scores, and coagulation-related physiochemical indices(complete blood count, four coagulation tests, and four thrombosis tests) were collected and compared before treatment and after three months of treatment. Peripheral blood samples from three patients with significant efficacy were subjected to transcriptome sequencing before and after treatment to screen differentially expressed genes(DEGs). GO and KEGG enrichment and PPI network analysis were performed. Genes most relevant to the core phenotype of SONFH with meridian blockage syndrome were identified using Spearman correlation analysis. The results showed that Huoxue Tongbi Formula significantly improved the clinical efficacy scores(including pain and hip joint flexion function), Harris scores, and range of internal and external rotation of the hip(P<0.01). It also maintained stable imaging indices, alleviated various blood stasis-related clinical symptoms(hip pain, fixed pain, lower limb weakness)(P<0.05, P<0.001), and significantly reduced thrombin-antithrombin complex(TAT) levels(P<0.01). Transcriptome analysis identified 368 DEGs(274 upregulated and 94 downregulated). GO functional enrichment revealed that the biological processes involved by DEGs mainly include positive regulation of tumor necrosis factor production, integrin-mediated signaling pathways, neutrophil chemotaxis, and regulation of tumor necrosis factor production. KEGG enrichment analysis revealed that these DEGs were primarily involved in pathways such as hematopoietic cell lineage, osteoclast differentiation, complement and coagulation cascades, and platelet activation. PPI network analysis combined with correlation analysis identified core genes UBA52(r=0.83, P<0.05), RACK1(r=0.88, P<0.05), and RPL19(r=-0.87, P<0.05) were significantly correlated with blood stasis syndrome scores. CD74 was significantly correlated with osteonecrotic lesions(r=0.95, P<0.05) and TAT(r=0.88, P<0.05). These findings indicate that Huoxue Tongbi Formula ameliorates clinical symptoms and certain imaging indices in SONFH patients with meridian blockage syndrome by regulating hematopoiesis and bone metabolism(inhibiting osteoclast activity) and correcting hypercoagulability(inhibiting coagulation activation). Core genes such as UBA52, RACK1, and RPS3A may be key molecules linking blood stasis syndrome to the regulation of the coagulation-bone metabolism network. - Source: PubMed
Dong Peng-XuanMi Bao-HongLin NaZhang Yan-QiongChen Wei-Heng - is a perennial tetraploid wild relative of wheat that is widely distributed in China. It can be used both as a forage crop and ecological grass (the grasses specifically bred for ecological restoration) due to its strong stress tolerance, early green-up, vigorous seedling growth in spring, and great palatability. - Source: PubMed
Publication date: 2026/02/14
Luo QianyunLiu YueWang YifanZhang GuanghaoLiu JiafenLi HongxinLiang ZhenLiu YingBai LongLiu Sijia - BACKGROUND: Despite recent improvements in prognosis, breast cancer remains the leading cause of cancer-related mortality in women worldwide. Survival rates vary across breast cancer subtypes. HER2, an oncogene, is amplified in approximately 25% of primary breast cancers and associated with an aggressive clinical course and a poor prognosis. Although HER2-targeted therapies induce significant and durable responses, resistance remains prevalent.RPL19 is coexpressed and positively correlated with HER2. METHODS: Analysis of The Cancer Genome Atlas (TCGA) revealed RPL19 upregulation in HER2-amplified breast cancer. Further validation with paired breast cancer and adjacent normal tissues confirmed the differential expression of RPL19 in HER2-amplified breast cancer. In vitro and in vivo functional assays demonstrated that RPL19 promotes the growth and metastasis of HER2-amplified breast cancer cells. Mechanistically, RPL19 upregulates IL-4 via the transcription factor JUN. RPL19 promotes tumor cell proliferation, migration, and invasion, and reduces their sensitivity to trastuzumab through the IL-4/p-STAT6 signaling pathway. In the tumor microenvironment, RPL19 inhibits macrophage-mediated phagocytosis of tumor cells by regulating IL-4 secretion, further promoting tumor progression. RESULTS: In summary, RPL19 is overexpressed in HER2-amplified breast cancer and promotes tumor cell growth, metastasis, and reduces their sensitivity to trastuzumab. Through JUN-mediated regulation of IL-4, RPL19 influences the progression and reduces their sensitivity to trastuzumab of HER2-amplified breast cancer via the IL-4/p-STAT6 signaling and IL-4-mediated macrophage phagocytosis pathways. CONCLUSIONS: These pathways may represent novel therapeutic targets for HER2-amplified breast cancer. - Source: PubMed
Publication date: 2026/02/21
Zhang NanaZhang JianShao JunchaoHuang ZhenfengZhang JinxingWang HaoLv LiangshuangShen ZiboZhang PengLiu BingZhang GuoqiangShan Ming - This study aims to compare the protein expression profiles of plasma-derived exosomes in patients with sudden sensorineural hearing loss (SSNHL) and normal hearing control groups to identify exosome proteins that may be associated with SSNHL or serve as biomarkers for SSNHL. - Source: PubMed
Publication date: 2025/11/12
Li JuanjuanBai SuwenZhang PengZeng XianhaiKong Hui