CD161 antibody
- Known as:
- CD161 (anti-)
- Catalog number:
- orb100571
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CD161 antibody
Related genes to: CD161 antibody
- Gene:
- KLRB1 NIH gene
- Name:
- killer cell lectin like receptor B1
- Previous symbol:
- NKR
- Synonyms:
- CD161, NKR-P1, NKR-P1A, hNKR-P1A, CLEC5B
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-16
- Date modifiied:
- 2016-10-05
Related products to: CD161 antibody
Related articles to: CD161 antibody
- X-linked hypophosphatemia (XLH) is a rare hereditary disorder characterized by gene mutations, elevated levels, and impaired bone mineralization. Burosumab, a monoclonal antibody targeting , has demonstrated clinical efficacy; however, the immunological dynamics during treatment remain unexplored. This study employed longitudinal single-cell RNA sequencing (scRNA-seq) to characterize peripheral blood immune cell alterations across multiple treatment stages in pediatric XLH. We performed scRNA-seq on peripheral blood mononuclear cells from pediatric patients with XLH at five time points spanning pretreatment and burosumab therapy phases, along with healthy pediatric controls. A total of 93,112 cells were analyzed using comprehensive bioinformatic pipelines, including unsupervised clustering, pseudotime trajectory analysis, temporal gene expression profiling, and cell-cell communication inference. Eleven major immune cell populations were identified, with notable dynamic alterations in T cells and natural killer (NK) cell subtypes across treatment stages. The cellular proportion of T helper 2 (Th2) cells and regulatory T (Treg) cells were elevated before treatment and normalized during therapy, whereas T helper 17 (Th17) cells exhibited reciprocal patterns. Genes upregulated in Treg cells during early treatment were enriched in osteoclast differentiation pathway. Natural killer subtype 2 cells showed enrichment in osteoclast differentiation and interleukin-12 response pathways. Cell-cell communication analysis identified dynamic interactions among Th2 cells, Th17 cells, Treg cells, and NK cell subtypes mediated by KLRB1-CLEC2D and SELL-SELPLG ligand-receptor pairs. This longitudinal transcriptomic study provides the first comprehensive characterization of peripheral immune dynamics during burosumab therapy in XLH, offering new insights into the immunological mechanisms underlying treatment response. - Source: PubMed
Publication date: 2026/06/27
Xie YueLi LiLi RongSun YihongZhou TingCun YupengZhu Gaohui - CD1d-restricted invariant natural killer (iNK) T cells are innate T cells known for their ability to shape adaptive immunity toward inflammation or immune-suppression via the rapid production of Th1-, Th2-, and Th17-type cytokines from corresponding iNKT subsets such as NKT1, NKT2, and NKT17. IL-10-producing invariant NKT cells, termed NKT10 cells, are thought to play an immunoregulatory role, but their potential clinical use remains underexplored. We characterized human NKT10 cells from cord-derived iNKT cells and investigated their therapeutic utility in allogeneic stem cell transplantation. Cord and cord-derived iNKT cells contained a high frequency of CD4CD25CD161FoxP3 iNKT cells and showed Th2/Th10-biased cytokine production upon antigenic stimulation. Accordingly, cord-derived iNKT cells displayed a distinct gene expression profile with upregulated genes related to NKT2, NKT10, and regulatory T cells compared with adult donor-derived iNKT cells. Furthermore, single-cell RNA sequencing analysis of cord-derived iNKT cells confirmed the presence of NKT10-like subset that was enriched with multiple immunoregulatory pathways and genes related to immune-checkpoints (, , , and ) and NKT10 (, , and ), whereas the NKT1/17-like subset present in adult donor-derived iNKT cells showed upregulation of genes related to cytotoxicity (, , and ), NKR (, , , and ), NKT1 ( and ), and NKT17 (). Lastly, cord-derived iNKT cells suppressed alloreactive T cell proliferation and ameliorated xenogeneic graft-versus-host disease where the immunodeficient NSG mice received human peripheral blood mononuclear cells supplemented with cord-derived iNKT cells. Thus, NKT10-enriched, cord-derived iNKT cells are candidate cell therapeutics for immune-modulation in allogeneic stem cell transplantation and other autoimmune diseases. - Source: PubMed
Publication date: 2026/06/10
Trujillo-Ocampo AbelBorges PamellaGrefe MaisonVaz de Freitas MartielaLee Sung-EunQi YuanClinton JelitaLi DanHe HongYu LingPeris-Cuesta ArnauEhli Erik AMa QingSu XiaopingAmaral Antunes DinlerAl-Atrash GheathMolldrem Jeffrey JShpall Elizabeth JIm Jin S - Natural killer (NK) cells play a vital role in the immune response to infection, disease, and vaccination. Bovine NK cell subsets have been described; however, a more in-depth characterization is currently hindered by the lack of species-specific reagents in comparison to humans and mice. CD161, encoded by the gene, is a C-type lectin-like receptor known to be highly expressed in human NK cells. CD161 has been described in human immunity as defining a pro-inflammatory subset of NK cells that are capable of responding to cytokines. The specific function and importance of bovine CD161 cells have yet to be defined. This study developed and characterized a novel mouse anti-bovine CD161 monoclonal antibody and determined the expression of CD161 on NK cells, CD8 T cells, and gamma delta T (γδT) cells in peripheral blood from calves. Future research will investigate the specific function and targeting of the described CD161 subsets in baseline immune response, infection, and response to vaccination. - Source: PubMed
Publication date: 2026/06/03
Dry IngaKalandadze MartaWu ZhiguangMcGuinnes Irene CEdmans Matthew DBenedictus LindertConnelley TimothyHope Jayne CWaddell Lindsey A - The CD161 protein encoded by the killer cell lectin-like receptor subfamily B member 1 (KLRB1) gene is a key immunoregulatory molecule, primarily expressed in natural killer (NK) cells and specific T cell subsets, playing a significant role in tumors and various immune-related diseases. With the application of multi-omics big data and single-cell sequencing technologies, the mechanisms by which KLRB1 functions in tumorigenesis, progression, and immune microenvironment regulation are becoming increasingly clear. This paper elucidates the mechanism by which KLRB1 mediates immune activation and immune evasion through the regulation of downstream signaling pathways, its multifaceted roles within the tumor microenvironment (TME), and explores its function in immunotherapy. This article systematically reviews the expression characteristics of KLRB1 in various cancers such as breast cancer, hepatocellular carcinoma, and colorectal cancer, and analyzes the correlation between its expression levels and patient prognosis as well as immune cell infiltration in the TME. Beyond the field of oncology, the important role of KLRB1 in other immune-related diseases such as sepsis, psoriasis, and osteoporosis is also increasingly prominent. In-depth research on KLRB1 will provide new insights for future diagnostic and therapeutic strategies for the aforementioned diseases. - Source: PubMed
Publication date: 2026/06/13
Hu JiaMeiGuan JiayuZhang LilingLi Shaoying - Decidual natural killer (dNK) cells constitute approximately 70% of first-trimester decidual leukocytes and play critical roles in immune tolerance, angiogenesis, and trophoblast invasion. Single-cell RNA sequencing has revealed substantial heterogeneity within the dNK population, identifying three major subsets-dNK1, dNK2, and dNK3-with distinct transcriptomic profiles and predicted functions. dNK3 Characteristics: dNK3 cells are characterized by a CD160KLRB1CD103CD39 surface phenotype, T-bet-high/Eomes-intermediate transcription factor profile, and phenotypic resemblance to intraepithelial type 1 innate lymphoid cells (ieILC1). These cells demonstrate the highest effector capacity among dNK subsets, producing multiple cytokines (CCL5, XCL1, IFN-γ, GM-CSF) following stimulation. Predicted ligand-receptor interactions include CCL5-CCR1 with extravillous trophoblasts, XCL1-XCR1 with dendritic cells, and inhibitory axes through KLRB1-CLEC2D and TIGIT-PVR. Notably, dNK3 abundance undergoes dynamic changes across gestation and shows distinct spatial distribution within decidual compartments. - Source: PubMed
Publication date: 2026/05/13
Liu LidanZhang ZhaoHuang QianyiLiu BoWu Hongbo