EphA3 antibody
- Known as:
- EphA3 (anti-)
- Catalog number:
- orb100577
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- EphA3 antibody
Related genes to: EphA3 antibody
- Gene:
- EPHA3 NIH gene
- Name:
- EPH receptor A3
- Previous symbol:
- ETK, ETK1, TYRO4
- Synonyms:
- HEK, HEK4
- Chromosome:
- 3p11.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-23
- Date modifiied:
- 2016-10-05
Related products to: EphA3 antibody
Related articles to: EphA3 antibody
- To undertake a Phase 1 and Biodistribution study of the EphA3 antibody ifabotuzumab, and its zirconium labelled derivative 89Zr-ifabotuzumab, in glioblastoma patients. - Source: PubMed
Publication date: 2026/06/10
Gan Hui KCher LawrenceInglis Po-LingLwin ZarnieGunjur AshrayBalasubramanian AdiSchmidt AndrewWichmann Christian WGuo NancyLee Sze TingThomas PaulScott Fiona EShard ChloeFluck KateCoombs NicolePalmer JodieVail Mary EAllen StaceyPatil AshwiniPal BhupinderO'Keefe Graeme JGong Sylvia JNinatti GaiaDay Bryan WGomez Guillermo AJanes Peter WScott Andrew M - Degenerative temporomandibular joint diseases (TMJ-DJD) are increasingly affecting elderly populations, with aging being a significant risk factor driving the TMJ degenerative changes. This study aims to explore the shared characteristics between aging and TMJ degenerative diseases at the tissue level, and to identify aging-related signature genes in TMJ degenerations using bioinformatics approaches. - Source: PubMed
Publication date: 2026/06/09
Wang XinyiXia ZiyangZhou YanzhangWang MindaJiang TingYang Jingwen - Head and neck squamous cell carcinoma (HNSCC) is characterized by a highly immunosuppressive tumor microenvironment (TME), with tumor-associated macrophages (TAMs) playing a central role in resistance to therapy. The immune checkpoint molecule CD47, known for its "don't eat me" signal, and EphA3, a receptor tyrosine kinase, are both upregulated in radiation-resistant HNSCC. However, their cooperative role in regulating TAMs and therapeutic resistance remains poorly understood. - Source: PubMed
Publication date: 2026/05/15
Kim Song HeeKim Ji WonKim Min SeokCha Hee JeongKim Seong WhoHan Myung Woul - Investigating the genetic underpinnings of functional brain connectivity is essential to understand how genetic variation influences brain health and disease. Here, a mass-univariate approach was adopted to study the genetic architecture of functional brain circuitry (N = 28,159 subjects) with high spatial resolution (82 brain regions). Common genetic variants explained individual differences in 33% of all 3321 inter-regional functional pathways with 72 significant associations reflecting widespread, pleiotropic effects across the connectome. These associations were mapped to five genes-PAX8, EphA3, SLC39A12, THBS1 and APOE-with known associations with brain phenotypes and which converged in biological processes related to neurodevelopment and cardiovascular and cognitive traits (enrichment minimum p = 3.0 × 10 and p = 1.6 × 10, respectively). Our findings show that the genetic component of individual differences in functional brain connectivity is largely shared throughout the brain, highlighting the importance of genetic variation in large-scale brain organisation and its relationship with cognitive function and overall health. - Source: PubMed
Publication date: 2026/02/24
Maciel Bernardo de ApcSchipper MarijnRomero Catode Leeuw ChristiaanHelwegen KoenPosthuma DanielleSavage Jeanne Evan den Heuvel Martijn P - Enhancing growth traits is a key goal in sustainable meat goat production and is often regarded as a primary objective in breeding programmes for meat goats. In this study, whole genome low-depth sequencing data of 300 Longling yellow female goats were used to detect the genome-wide single-nucleotide polymorphisms (SNPs), and the genome-wide association study (GWAS) based on SNPs was performed for the BW, body height (BH), body length (BL), chest circumference (CC), chest depth (CD), chest width (CW), and cannon circumference (cc) at the ages of 3, 9, and 12 months. After genotype imputation and quality control, 6 153 300 SNPs were retained for further analysis. A total of 129 genome-wide significant SNPs were obtained, and these SNPs were annotated to 146 candidate genes associated with body size traits, such as MMP16, MECOM for BW; SCD5, LEF1 for BL; and PDE4D, KCND2 for BH. EPHA5 is pleiotropic, associated with BW, BL, BH, CC, and CW. Notably, ADAMTS3 was linked to CD, while GIGYF2 and DGKB were associated with cc. Functional analysis revealed that 13 candidate genes are implicated in pivotal biological processes, including extracellular matrix organisation and lipid metabolism. Notably, EPHA5, ROS1, and EPHA3 were significantly enriched in molecular functions related to growth factor receptor activity. These findings offer valuable genetic markers for genomic selection in goats, thereby providing resources for advancing precision breeding programmes. - Source: PubMed
Publication date: 2026/01/22
He X YWei Y SKuang J CLi Z FYu Z XWang X YDi RZhu C YChu M X