TSPYL5 antibody
- Known as:
- TSPYL5 (anti-)
- Catalog number:
- orb100625
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- TSPYL5 antibody
Related genes to: TSPYL5 antibody
- Gene:
- TSPYL5 NIH gene
- Name:
- TSPY like 5
- Previous symbol:
- -
- Synonyms:
- KIAA1750
- Chromosome:
- 8q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-05
- Date modifiied:
- 2016-12-15
Related products to: TSPYL5 antibody
Related articles to: TSPYL5 antibody
- Hyperactivation of the PI3K/AKT pathway is a hallmark of metastatic triple-negative breast cancer (TNBC), but its drivers in TNBC retaining wild-type PTEN are poorly understood. Here, we identify Testis-Specific Y-Like Protein 5 (TSPYL5) -the top metastasis-associated gene from an unbiased bioinformatics screen- as a master regulator that resolves this paradox. Clinically, TSPYL5 amplification and overexpression are robust predictors of metastatic progression and poor prognosis. High-resolution single-cell and spatial analyses reveal that TSPYL5 defines a malignant subpopulation with stem-like, genomically unstable, and pro-metastatic properties. Functionally, TSPYL5 is sufficient to drive spontaneous polymetastasis from orthotopic tumors and is indispensable for post-intravasation colonization, culminating in overt liver metastases in 60% of animals-a phenotype absent in controls. Mechanistically, TSPYL5 sequesters the deubiquitinase USP10, thereby preventing it from stabilizing the tumor suppressor PTEN. This TSPYL5-USP10 interaction triggers the proteasomal degradation of PTEN, circumventing its wild-type status to hyperactivate PI3K/AKT signaling and unleash a ZEB1-driven metastatic program. This study delineates a complete TSPYL5-USP10-PTEN axis, providing a new paradigm for the post-translational tumor suppressor inactivation in TNBC. Our work validates TSPYL5 as a biomarker for PI3K pathway dependency and establishes the TSPYL5-USP10 interface as a tractable therapeutic target to restore PTEN function and combat metastatic TNBC. - Source: PubMed
Publication date: 2026/06/04
Shi JiayingYi MingXie ShengyuWang ZhaokunZhang XinyueZhang YangweiTang RuiYang YuanLiu Yunqiang - Intrahepatic cholangiocarcinoma (iCCA) is characterized by heterogeneity and poor survival. It remains unclear how telomere maintenance programs influence the prognosis and immune microenvironment in iCCA, and clinically applicable, telomere‑anchored transcriptomic tools are currently lacking. - Source: PubMed
Publication date: 2026/05/30
Wang LihuaZhao WenjingCui ZhongfengLi Guangming - Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors. We combined whole-genome bisulfite sequencing (WGBS) and mRNA-seq data from 33 paired hepatocellular carcinoma (HCC) and adjacent tissues to identify methylation markers that could be used for noninvasive diagnosis in blood samples. Methylation markers were selected according to the following criteria: differentially methylated regions (DMR) located in the promoter region with large differences in methylation (Δβ > 0.3) and inverse correlation with matched gene expression (cor < -0.3). Cell-free DNA (cfDNA) from 48 patients with HCC and 24 normal participants was used to verify the performance of meTSPYL5 using qMSP. Integrated WGBS and transcriptomic data analysis identified eight target promoter hyper-DMRs. After confirming the WGBS profiles of genes in peripheral blood mononuclear cells, meTSPYL5 was selected to further verify the plasma cfDNA samples by qMSP. The results of plasma validation showed that the methylation detection of meTSPYL5 was sensitive for identifying HCC, with a sensitivity and specificity of 85.4% and 100%, respectively. Pan-cancer analysis found that the methylation level of TSPYL5 was elevated in multiple cancer types, indicating that it lacks cancer-type specificity; however, this result does not affect its application value in monitoring high-risk populations of HCC. By analyzing and integrating all available high-throughput epigenomic and transcriptomic data from human HCC tissues, we identified eight regions as potential diagnostic biomarkers for HCC. Integrative analyses of epigenomic and transcriptomic data provide an efficient method to identify diagnostic biomarkers for human cancers. Methylated TSPYL5 in plasma is a promising biomarker for the detection and screening of HCC. - Source: PubMed
Publication date: 2026/03/01
Zhao JunshengShen SijiaZhang JunjieXu YingPeng JingGao HainvLi Lanjuan - Early detection of hepatocellular carcinoma (HCC) represents a significant clinical challenge due to the lack of effective biomarkers. Previous studies have revealed abnormal hypermethylation of RASSF1A and TSPYL5 in HCC tissues, prompting further investigation into their utility as potential biomarkers for HCC diagnosis. In this study, we explored the clinical value of RASSF1A/TSPYL5 methylation alone and in combination with AFP protein as diagnostic biomarkers for early HCC detection. - Source: PubMed
Publication date: 2025/11/18
Chen HaiyanLuo YingminLi LinhongXu FeiLai XiaohuanLi JinlongLi XiaomoSong WenjieLiu YangBao DengkeLiu JiayunZhou GuanlinWan Shaogui - Epstein-Barr virus (EBV) infection is a well-established trigger and risk factor for both myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID syndrome (PCS). In previous studies, we identified elevated IgG responses to arginine-rich (poly-R) sequences within the EBV nuclear antigens EBNA4 and EBNA6 in post-infectious ME/CFS (piME/CFS). Building on these findings, this exploratory study examines IgG reactivity to poly-R-containing EBV-derived peptides and homologous human peptides in women with PCS and ME/CFS. - Source: PubMed
Publication date: 2025/09/19
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