CABLES1 antibody
- Known as:
- CABLES1 (anti-)
- Catalog number:
- orb100645
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CABLES1 antibody
Related genes to: CABLES1 antibody
- Gene:
- CABLES1 NIH gene
- Name:
- Cdk5 and Abl enzyme substrate 1
- Previous symbol:
- -
- Synonyms:
- HsT2563, FLJ35924
- Chromosome:
- 18q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-09
- Date modifiied:
- 2016-01-14
Related products to: CABLES1 antibody
Related articles to: CABLES1 antibody
- Pituitary adenomas are increasingly recognised to have a germline genetic component in a subset of patients, particularly those with young-onset disease, familial clustering or syndromic features. The spectrum of germline variants implicated in pituitary tumorigenesis has broadened considerably, with evidence of both established predisposition genes and a growing number of emerging candidate genes. Established germline predisposition genes - namely, MEN1, PRKAR1A, AIP, CDKN1B, GPR101, SDHx and MAX - remain central to our understanding of familial pituitary adenoma predisposition and have defined roles in specific clinical contexts which influence adenoma phenotype, age at presentation, surveillance strategies and family screening. Beyond this, a set of less prevalent variants in other genes - for example, CABLES1, CDH23, PAM, CHEK2 and the mismatch repair (MMR) genes - are emerging as potential contributors, although the pathogenicity and clinical relevance of these genes remain to be fully established. Identifying causative germline variants in people with pituitary adenomas offers the opportunity of personalised care via gene-specific surveillance strategies, prognostication, cascade testing and reproductive planning to the potential benefit of the individual as well as their families. In this review, we provide a clinically-orientated overview of the established and emerging genes implicated in the germline predisposition to pituitary adenomas. We also present a contemporary clinical approach to germline genetic testing in patients with pituitary adenomas. - Source: PubMed
Publication date: 2026/05/16
Mignone EdwardSorvina AlexandraTorpy David JScott Hamish SDe Sousa Sunita M C - Radiotherapy is a mainstay of cancer treatment, yet its efficacy is still substantially restricted due to radioresistance. The mechanisms underlying radioresistance remain elusive, impeding drug development and therapeutics. Here, using a high-throughput random gene perturbation method based on piggyBac transposon, we screened and identified CABLES1, an adaptor protein, as a key regulator of tumor radioresistance. The function of CABLES1 in radioresistance was further validated in multiple human cell lines in vitro and a mouse xenograft model in vivo. High expression of CABLES1 is significantly correlated with radioresistance in cancer patients. Mechanistically, CABLES1 interacts with XRCC6/XRCC5 heterodimer and activates DNA-PKcs by promoting DNA-PK holoenzyme formation, thus facilitating the efficiency of nonhomologous end-joining (NHEJ) repair and radioresistance. Notably, YTHDF1 recognizes METTL14-deposited mA modification on CABLES1 mRNA to enhance its translation in response to ionizing radiation (IR), thereby sustaining the elevation of NHEJ repair capacity and radioresistance. Through high-throughput screening of a small molecule library, we showed that theaflavin 3,3'-digallate (TF-3) specifically disrupts the CABLES1-XRCC6 interaction, thereby sensitizing cancer cells to radiotherapy. Together, our study unveils the molecular mechanism by which CABLES1 potentiates tumor radioresistance, providing a novel synthetic lethal strategy for targeting cancer. - Source: PubMed
Publication date: 2026/05/09
Li ChangzhiTang XianchaoZeng ZimiYang LiqianCao FangZhu HaiyanZhu LiqingShen JieBian XiaocuiWang LibinLiu YangMao FengbiaoChang DeJiao PengtaoWang HaiyingLi Kailong - Approximately 5% of pituitary adenomas (PA) are familial, linked to germline variants in AIP, or syndrome-related genes like MEN1. While somatic GNAS and USP8 variants predominate in specific subtypes, PAM and CABLES1 genes are emerging. - Source: PubMed
Martinez de Lapiscina IdoiaBaquero CandelaSantos AliciaMolina Ana RosaMoure Maria DoloresAramburu MaiteBancalari RodrigoBoronat MauroBueno GloriaCasano-Sancho PaulaFernandez-Ramos ConcepcionGarcia-Garcia EmilioGonzalez AmparoGonzalez-Rivera NatividadGuerrero-Fernandez JulioHernandez Maria IsabelPaja MiguelPortillo NancyRica ItxasoSoto-Moreno AlfonsoSuarez-Ortega LarisaVela AmaiaCastaño LuisValdes Nuria - Cushing's disease is a rare endocrine disorder characterized by excessive endogenous glucocorticoid production, primarily resulting from adrenocorticotropic hormone-secreting pituitary neuroendocrine tumors (ACTH-PitNETs). This study investigated the expression of several genes implicated in the development of ACTH-PitNETs, including EGFR, USP8, CABLES1, USP2, STAM2, VPS28, HDAC2, IL-6, SMARCA4, WEE1, CDKN2A, CCND1, NR4A1, NEUROD1, and RIPK1. The methylation levels of the USP8 and CDKN2A genes were also assessed for insights into their regulatory mechanisms.Formalin-fixed paraffin-embedded pituitary tumor tissue samples from 32 patients diagnosed with ACTH-PitNET and 15 anterior pituitary tissue samples were analyzed. Gene expression was analyzed through quantitative reverse transcription polymerase chain reaction, while methylation was examined through methylation-specific polymerase chain reaction. All data were analyzed with IBM SPSS Statistics 21. The relationships among gene expressions were assessed using principal component analysis.The expression of CABLES1, NR4A1, CCND1, NEUROD1, USP2, and WEE1 differed significantly between the patient and control groups. Additionally, significant correlations were observed between the levels of RIPK1, SMARCA4, and USP2 and pre-operative cortisol levels; WEE1 expression and pre-operative ACTH levels; CDKN2A expression and urinary cortisol levels; CABLES1, NEUROD1, SMARCA4, and STAM2 expression and post-operative cortisol levels at 48 h. CCND1 expression was correlated with adenoma size, while WEE1 expression was linked to remission status. Notably, the CDKN2A gene displayed partial methylation, whereas the USP8 gene was fully unmethylated.The altered expression levels of the USP2, CABLES1, CDKN2A, and WEE1 may be closely associated with the development of ACTH-PitNETs. Notably, WEE1 emerged as a target gene for predicting clinical remission in patients with Cushing's disease. - Source: PubMed
Publication date: 2025/07/30
Kayacan SeraGazioglu NurperiOrhan CerenComunoglu NilKadioglu PinarTanriover NecmettinUysal OmerKaya Dagistanli FatmaOzturk Melek - This study investigates the effects of T-2 toxin metabolite HT-2 alone or combined with Akt1 on chondrocyte gene expression to elucidate their roles in Kashin-Beck disease (KBD) pathogenesis. - Source: PubMed
Publication date: 2025/05/29
Liao XinhuaYang XiaodongJia XiaoqianZhang QianNaren GaowaZhang JiaojiaoNiu HuiWei HaiyanWu Cuiyan