SEZ6L antibody
- Known as:
- SEZ6L (anti-)
- Catalog number:
- orb100711
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- SEZ6L antibody
Related genes to: SEZ6L antibody
- Gene:
- SEZ6L NIH gene
- Name:
- seizure related 6 homolog like
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 22q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-12
- Date modifiied:
- 2016-04-19
Related products to: SEZ6L antibody
Related articles to: SEZ6L antibody
- [This corrects the article DOI: 10.3389/fimmu.2021.607641.]. - Source: PubMed
Publication date: 2026/05/21
Qiu Wen QLuo ShaopeiwenMa Stefanie ASaminathan PriyankaLi HermanGunnersen Jenny MGelbard Harris AHammond Jennetta W - Neuropathic pain (NP) is a prevalent chronic pain disorder that severely impairs the physical and mental health of patients, affecting 6.9%-10% of the general population. The dorsal root ganglion (DRG) is a crucial locus in the pathogenesis of NP. However, the underlying mechanisms by which DRGs contribute to this condition remain incompletely understood. - Source: PubMed
Publication date: 2026/04/20
Hu LiminChen Junjie - This study explored protein expression in B-cell acute lymphoblastic leukemia (B-ALL) patients with and without elevated weight or obesity and controls to understand global proteomic differences between newly diagnosed B-ALL patients and controls as well as the influences of elevated body mass index (BMI) on pretreatment inflammatory and immune-related protein expression in B-ALL patients. Protein expression was measured in serum samples of pediatric patients (aged 1-21 years) with newly diagnosed B-ALL ( = 39), and age and sex-matched controls ( = 41) using OLink panels. We examined normalized protein expression data clustered by patient information in -unsupervised hierarchical clustering and principal component analysis. Of 239 assays, 128 assays differed significantly based on B-ALL diagnosis and 4 assays (APLP1, CDHR5, GHRL, SEZ6L) varied significantly as a function of BMI. In healthy individuals, oncology marker furin (p.adjust = 0.016) was more highly expressed in the high-BMI category; this trend was reversed for B-ALL individuals. Furin expression is often upregulated in malignancies and obesity; however this suggests its expression may follow unique patterns in pediatric B- ALL patients with elevated BMI. - Source: PubMed
Publication date: 2026/04/28
Werk Rachel SChacón Jeremy MTurcotte Lucie MRyder Justin R - Genetic factors have been increasingly recognized as important contributors to the development and progression of adolescent idiopathic scoliosis (AIS). However, the genetic basis underlying AIS curve severity remains largely unclear. The objective of this study is to identify novel genetic variants associated with curve severity in AIS through a genome-wide association study (GWAS). - Source: PubMed
Publication date: 2026/01/19
Dai ZhichengWu ZhichongXu LeileiFeng ZhenhuaQiu YongZhu Zezhang - The SEZ6 family, composed of SEZ6, SEZ6L, and SEZ6L2, plays essential roles in neurodevelopment, synaptic organization, and complement regulation. However, the specific contribution of SEZ6L2 to brain function remains largely unexplored. In this study, we provide the first comprehensive behavioral and neurobiological characterization of knockout (KO) mice and directly compare their phenotype with triple knockout (TKO) mice, which lack all three family genes. KO mice exhibit impairments across multiple behavioral domains, including motor coordination, gait, sociability, sensory processing, and goal-directed repetitive behaviors. Several phenotypes, particularly motor deficits, worsen with age. Male KO mice also demonstrate enhanced fear learning and increased prepulse inhibition, revealing sex-specific alterations in sensorimotor gating. At the synaptic level, KO mice show reduced dendritic spine length and decreased expression of key postsynaptic proteins suggesting impaired excitatory synaptic connectivity. These structural and molecular abnormalities likely contribute to the observed behavioral deficits. In comparison, TKO mice display more severe impairments across most measures. Together, these findings establish SEZ6L2 as a critical and non-redundant regulator of motor, cognitive, and synaptic function and provide mechanistic insight into how dysfunction within the SEZ6 family may contribute to neurodevelopmental and neurodegenerative disorders. - Source: PubMed
Publication date: 2026/01/01
Granato Julia MSilver NinaHobbins AlisonRandolph JohnStout AngelaGelbard Harris AGunnersen Jenny MMackenzie Samuel JWhite Patricia MHammond Jennetta W