WNT2 antibody
- Known as:
- WNT2 (anti-)
- Catalog number:
- orb100714
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- WNT2 antibody
Related genes to: WNT2 antibody
- Gene:
- WNT2 NIH gene
- Name:
- Wnt family member 2
- Previous symbol:
- INT1L1
- Synonyms:
- IRP
- Chromosome:
- 7q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-05
- Date modifiied:
- 2016-10-05
- Gene:
- WNT2B NIH gene
- Name:
- Wnt family member 2B
- Previous symbol:
- WNT13
- Synonyms:
- XWNT2
- Chromosome:
- 1p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-05
- Date modifiied:
- 2016-10-05
Related products to: WNT2 antibody
Related articles to: WNT2 antibody
- Xerostomia, the subjective sensation of dry mouth, is a debilitating consequence of head and neck radiotherapy and autoimmune disorders such as Sjögren’s syndrome. It severely impairs oral health and quality of life by promoting mucosal ulceration, infection, malnutrition, and speech difficulties, yet effective regenerative treatments remain limited. Macrophages have recently emerged as critical regulators of salivary gland repair through their roles in coordinating inflammation, fibrosis, and epithelial regeneration; however, the molecular mechanisms governing macrophage activation and function in the injured salivary gland remain poorly defined. The Wnt/β-catenin signalling pathway is a key regulator of inflammation and tissue homeostasis across multiple organs, but its role in salivary gland macrophages has not been well characterised. Here, we investigated canonical Wnt/β-catenin signalling following murine submandibular gland injury induced by main excretory duct ligation, with deligation used in selected experiments to model repair. Using Axin2CreERT2/+;R26mTmG/+ reporter mice, we observed an increase in Axin2⁺ cells and substantial recruitment of F4/80⁺ macrophages exhibiting active Wnt/β-catenin signalling within the injured, ligated gland. qPCR-based gene expression analysis revealed increased expression of Axin2, F4/80, and several Wnt genes, including Wnt2 and Wnt2b, at days 3 and 6 post-injury, and identified Wnt2 and Wnt2b as macrophage-secreted ligands. Notably, despite the injury-associated increase in Wnt/β-catenin signalling, Axin2⁺ cells did not give rise to acinar cells following deligation. Finally, conditional depletion of Wntless (Wls) using pCAGCreERT2/+;Wlsfl/fl. and Axin2CreERT2/+;Wlsfl/fl mice increased the number of CD206⁺ macrophages and reduced fibrosis, indicating a potential association between Wnt signalling, macrophage polarisation, and fibrotic repair. Together, these findings identify Wnt/β-catenin signalling as a regulator of macrophage phenotype and tissue repair in the injured salivary gland, suggesting that targeted modulation of Wnt activity may promote regeneration and enhance functional recovery. - Source: PubMed
Publication date: 2026/03/11
Ahmed ArazSachdeva SuveerWhawell SimonMiletich Isabelle - The mechanisms that regulate the even spacing of placodes during embryonic development remain intriguing. These mechanisms typically involve complex interactions between signaling pathways, which can be further influenced by mechanical forces as the embryo grows. Here, we investigate the patterning of the ring of conjunctival placodes in the anterior eye of chicken embryos by functionally manipulating the BMP signaling pathway. Specifically, we electroporated a TWSG1 plasmid at HH27 to modulate BMP signaling during the pre-patterning phase and examined the effects on placode formation and key developmental pathways. Our results show that modulation of BMP signaling at HH27 influences placode development, morphology and spacing three days later, at HH34. qPCR data confirm an initial and statistically significant upregulation of FGF20 and WNT2B 6 h after electroporation. However, one day later (at HH29), only β-catenin is significantly elevated. Multiplex fluorescent in situ hybridization shows WNT2 expression in the conjunctival placodes and papillae for the first time. This WNT2 expression is colocalized with β-catenin in controls and remains spatially colocalized after electroporation. Together, these results provide functional evidence that BMP signaling regulates both canonical WNT/β-catenin and FGF pathways during early placode formation and support a model in which BMP may act as the inhibitor in a Turing-like reaction-diffusion mechanism underlying conjunctival placode patterning in the anterior eye. - Source: PubMed
Publication date: 2026/01/17
Herold AveevaFranz-Odendaal Tamara Anne - WNT signaling plays a key role in maintaining the gastric epithelium and promoting tumorigenesis. However, how gastric tumors achieve WNT niche independence remains unclear, as mutations on APC or CTNNB1-common mechanisms of ligand-independent WNT activation in colorectal cancer-are infrequent in gastric cancer. Understanding how WNT self-sufficiency is acquired in the stomach is therefore critical. - Source: PubMed
Publication date: 2025/12/16
Lee JaehunKim SoominOh YoungchulJahn Stephan RKim JihoonKim YeongjunSchmäche TimKim Sang-MinTeriyapirom IsareeGroß ThomasKwon OhbinKim JungminKim SomiAda Anne-MarlenCatalà-Bordes AndreaCho YoungwonKim JinhoAndersson-Rolf AmandaMerker Sebastian RLim Joo YeonPark Ji-YeonKlompstra Thomas MYoon Ki-JunLim Dae-SikLee Ho-SeokKim Jong KyoungChoi EunyoungGoldenring James RCheong Jae-HoKim HyunkiStange Daniel ELee HeetakKoo Bon-KyoungLee Ji-Hyun - Wnt signaling has long been implicated in cancer development, but recent studies have revealed new insights into how Wnt ligands themselves drive metastasis. Currently, research identifies Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt8a, Wnt9b, Wnt10a, Wnt10b, and Wnt16 as pro-metastatic Wnt ligands, while Wnt7a, Wnt7b, Wnt8b, Wnt9a, and Wnt11 exhibit conflicting pro- and anti-metastatic roles. These ligands arise from diverse sources in the tumor microenvironment and perform a wide range of roles in the metastatic cascade, including epithelial-to-mesenchymal transition, matrix metalloproteinase production, cell motility, angiogenesis, cell death resistance, and mesenchymal-to-epithelial transition. Their diverse and critical roles in metastasis make Wnt ligands attractive therapeutic targets. - Source: PubMed
Caroland Kailey PTrapani Jonathan BLee EthanWeiss Vivian L - The interaction between muscle and bone is shown to be clinically important but the underlying mechanisms are largely unknown. The canonical Wnt/β-catenin signaling pathway is reported to be involved in muscle-bone crosstalk, but its detailed function remains unclear. This systematic review aims to investigate and elucidate the role of the Wnt/β-catenin signaling pathways in muscle-bone crosstalk. - Source: PubMed
Publication date: 2024/06/20
Lin WujianChow Simon Kwoon HoCui CanLiu ChaoranWang QianjinChai SenlinWong Ronald Man YeungZhang NingCheung Wing Hoi